Objective To investigate the factors of lifestyle associated with the mild cognitive impairment (MCI). Methods A 1∶ 2 matched case-control study investigated 120 patients of MCI and 240 healthy controls with lifestyle factors associated with MCI. Results Multiple factors analysis confirmed that, participate in social activities (OR=0.562, 95%CI: 0.359~0.723), playing chess or joke (OR=0.603,95%CI: 0.323~0.884), travelling (OR=0.683, 95%CI: 0.467~0.912), continue to work after retirement (OR=0.531, 95%CI: 0. .326~0.724),reading (OR=0.272, 95%CI: 0.174~0.428), using computer (OR=0.536, 95%CI: 0.427~0.869), regular physical exercise (OR=0.437, 95% CI: 0.316~0.732), friendship (OR=0.583, 95%CI: 0.385~0.765), meeting children (OR=0.464, 95%CI: 0.316~0.745), intaking unsaturated fatty acids (OR=0.524, 95%CI: 0.368~0.787), often eating fish and seafood (OR=0.224, 95%CI: 0.171~0.383), daily consumption of fruits and vegetables (OR=0.485, 95%CI: 0.316~0.665) were protective factors for MCI. Conclusion A positive, leisure lifestyle, health reasonable diet and avoiding risk factors could effectively reduce the risk of MCI.

Objective To observe the effect of 3R therapy on quality of life and subjective well-being in older patients with mild cognitive impairment (MCI). Methods 158 patients with MCI were collected from 8 communities in Ningbo city with Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV as the diagnostic criteria, and assessed by Montreal Cognitive Assessment (MoCA). The experimental group (n=79) was intervened by 3R (Reminiscence, Reality Orientation, Remotivation) for 12 weeks, and the control group (n=79) received no intervention. Their quality of life was assessed with WHO Quality of Life-BREF (WHOQOL-BREF) and the subjective well-being was assessed with Philadelphia Geriatric Center Morale Scale (PGC). Results Their quality of life and subjective well-being improved after intervention in the experimental group (P<0.05), and were better in the experimental group than in the control group (P<0.05). Conclusion 3R therapy could effectively improve the quality of life and subjective well-being in patients with MCI.