Objective To explore the influences of Jinganning decoction on the content of CYP2E1 and cytokine IL-6,TNF in rats models of alcohdic hepatic injury.Methos 72 male Wistar clean level rats were randomly divided into 6 groups:blank control group,Jiuganning drug toxicity test group,alcoholic hepatic disease model group,Yiganling treatment group,Jiuganning low dose group,and Jiuganning high dose group.Blank control group was treated with physiological saline;Jiuganning drug toxicity test group was treated with Jiuganning decoction to observe toxicity and side effects.Jiuganning low and high dose treatment group were treated with 17.5 g/kg and 23.5 g/kg crude drug.Yiganning treatment group were treated with 0.206 g/kg crude drug.After 4 weeks'treatment,the content of TNF,IL-6,MDA as well as the activity of CYP2E1 and SOD were measured.Results Compared with the alcoholic hepatic disease model group,the content of IL-6(F=46.281,9.101),TNF and the activity (F=62.537)of CYP2E1 of all treatment group were significantly improved(P＜0.01).The content of SOD(F=19.210)in the rats serum of all treatment group was significantly increased while the MDA(F=34.952)was decreased.All the indexes in the treatment group had significant differences with the alcoholic hepatic disease and model group(P＜0.01).Conclusions The mechanism of Jiuganning decoction can effectively reduce the content of CYP2E1 and IL-6,TNF-a,with the changes of cell physiopathology and the influences of relevant enzymes,reveals the functional routines of the decoction treating hepatic injury:anti-lipid peroxidative,adjusting cytokine's activity,protecting hepatocyte,palliating the hepatocyte inflammation,and easing fibration.

A tumor suppressor gene at 10q23.3, designated PTEN, encoding a dual specificity phosphatase with lipid and protein phosphatase activity, has been shown to play an important role in the pathogenesis of a variety of human cancers and sporadic tumor. In this paper, we reviewed the construction and function of PTEN, and the mechanism of activation in cancer especially in thyroid carcinoma.

Animals ; Child ; China ; Dairy Products ; Diet ; Health Promotion ; methods ; Health Status ; Humans ; Nutritional Status ; Nutritive Value

Objective To study the ankle-brachial index of the diabetic gangrene. Methods ABI of the sixty cases with type 2 diabetes were measured. The results were divided into four groups: normal, gently abnormal moderate abnormal severely abnormal group. Results 30 cases were normal, occupying 50% (P＞0.05), gently and moderate abnormal attained 5 cases (8.33%) and 4 cases (6.67%) respectively, and the rests 21cases were severely abnormal, occupying 35% (P＞0.05).Conclusion The normal ABI was not always indicating type 2 diabetes without the gangrene or tendency.

Female ; Fertility ; Humans ; Nutritional Status

During the past 30 years, Alzheimer's disease (AD) drug R&D aiming at a variety of potential targets has undergone tremendous setback although a large amount of resources have been invested by pharmaceutical companies, governments, academic institutions and venture capitals globally. There is no doubt that uneasy early diagnosis, unsatisfying therapeutic strategies and genetic polymorphism of AD patients bringing variety of responses to the drugs contribute to the failure of AD drug therapy, but the most important reason might be that people have insufficient understanding of the very complex diseases including AD. Continuing to make efforts in the previous way to find AD drugs might not be a good way. Development of systems biomedicine opens an avenue to understand the disease networks and pursue multi-target drugs R&D based on systems pharmacology theory; neural stem cell transplantation, and neurogenesis affected by small molecules might bring new hope for AD therapy; discovery of new biomarkers of AD will help the study of the pathogenesis and diagnosis of the disease and finally the discovery of new types of AD drugs.
Alzheimer Disease ; drug therapy ; Biomedical Research ; trends ; Humans

Pulmonary valve stenosis is a common congenital heart disease,and its early diagnosis and treatment can improve growth and prognosis in children with pulmonary valve stenosis.With the development of the diagnostics and treatment,percutaneous balloon pulmonary valvuloplasty has replaced surgery as the first choice for isolated pulmonary valve stenosis.This paper reviews the recent progress in diagnosis and treatment of pulmonary valve stenosis.

Late-preterm infants are the neonates whose gestational ages are from 34+(0-7) to 36+(67)weeks.Although they look like term infants,their organs are immature.So the incidence of complication and mortality in late-preterm infants are higher than those of term infants.Now people have gradually realized that we could reduce the incidence of late-premature birth by exploring the pathogenesis of late-premature birth and trying to intervene it.People also have found that some maternal risk factors during pregnancy lead to latepreterm birth easily,such as pregnancy hypertension,pregnancy anemia,premature rupture of membranes,etc.These factors have significant impacts on the growth and development of late-preterm infants after birth.This paper is to review the progress of some maternal factors of late-preterm infants and their short and long term risks.

Encephalopathy secondary to hereditary metabolic diseases leads to high mortality due to the difficulties in early diagnosis and timely treatment.Survivors are often left with severe sequelaes of the nervous system. A considerable number of hereditary metabolic diseases are not thoroughly understood, but pre-clinical or early-clinical diagnosis and treatment can be attempted with MRI which can generally optimize the outcome.

ObjectiveTo explore the clinical curative effect of different methods on anesthesia radical mastectomy. MethodsTo choose 120 patients with breast cancer,and divided into epidural group and general anaesthesia group according to different methods of anesthesia randomly, and monitored the changes of blood pressure, heart rate, blood oxygen saturation, norepinephrine, epinephrine and C-reactive protein of all patients during peroperative period, and analyzed the difference between the two groups. ResultsThe vital sign and level of stress hormone of patients of epidural group during peroperative period had no significant difference( all P ＜0.01 ). The vital sign and level of stress hormone of patients of general anaesthesia group intraoperation were significant different compared to preoperation and post operation( all P ＜ 0.01 ). ConclusionEpidural anesthesia had lighter stress reaction and stable vital sign than general anesthesia on radical mastectomy.