So in pharmaceutical microbiology teaching, we made education reform according to pharmaceutical characteristics, that is to revise syllabus, update teaching content, reform of teaching methods, use modern means of teaching to train students in innovative spirit and ability. Besides, we strengthen the practice of teaching, conduct comprehensive and applicative experiment, So that our educational content is more in line with teaching objectives of Chinese pharmacy specialty, and help students to engage in basic knowledge of microbiology, experiment skills, capacity to analysis and solve problems.

Objective Information of the funding projects supported by the National Natural Science Foundation of Xinjiang Medical University from 2011 to 2015 was collected and analyzed in this paper.It also summarized the successful experiences,existing problems of project management during the "12th Five-Year" period for future improvement.Methods Statistical analysis was carried out on the funding projects by the National Natural Science Foundation of China from 2011 to 2015.Results With the support of the National Natural Science Foundation of China,the scientific research work experienced rapid progress and great improvement in Xinjiang Medical university.Conclusions By summarizing and improving the level of fund management in our university,we can also provide support for the sustainable development of our university's scientific research.

To investigate the potential role of transforming growth factor (TGF)-β1 in liver fibrosis during Echinococcus granulosus infection, 96 BALB/c mice were randomly divided into 2 groups, experimental group infected by intraperitoneal injection with a metacestode suspension and control group given sterile physiological saline. The liver and blood samples were collected at days 2, 8, 30, 90, 180, and 270 post infection (PI), and the expression of TGF-β1 mRNA and protein was determined by real-time quantitative RT-PCR and ELISA, respectively. We also evaluated the pathological changes in the liver during the infection using hematoxylin and eosin (H-E) and Masson staining of the liver sections. Pathological analysis of H-E stained infected liver sections revealed liver cell edema, bile duct proliferation, and structural damages of the liver as evidenced by not clearly visible lobular architecture of the infected liver, degeneration of liver cell vacuoles, and infiltration of lymphocytes at late stages of infection. The liver tissue sections from control mice remained normal. Masson staining showed worsening of liver fibrosis at the end stages of the infection. The levels of TGF-β1 did not show significant changes at the early stages of infection, but there were significant increases in the levels of TGF-β1 at the middle and late stages of infection (P<0.05). RT-PCR results showed that, when compared with the control group, TGF-β1 mRNA was low and comparable with that in control mice at the early stages of infection, and that it was significantly increased at day 30 PI and remained at high levels until day 270 PI (P<0.05). The results of this study suggested that increased expression of TGF-β1 during E. granulosus infection may play a significant role in liver fibrosis associated with E. granulosus infection.
Animals ; Bile Ducts ; Echinococcus granulosus* ; Echinococcus* ; Edema ; Enzyme-Linked Immunosorbent Assay ; Eosine Yellowish-(YS) ; Hematoxylin ; Injections, Intraperitoneal ; Liver Cirrhosis* ; Liver* ; Lymphocytes ; Mice* ; RNA, Messenger ; Transforming Growth Factors ; Vacuoles