Podoplanin (PDPN), being mucin-like transmembrane sialoglycoprotein, is expressed on lymphatic endothelial cells, with its significant role in the development of inflammation, separation of blood and lymphatic circulation, platelet aggregation, integrity of the renal filtration barrier and alveolar. In recent years, many researches have demonstrated that PDPN is overexpressed on the surface of some tumor cells. The interaction between PDPN and CLEC-2 plays an important role in the development of tumor growth, migration and transfer, therefore, anti-PDPN antibody offers a new direction for the treatment of tumor patients. This paper aims at reviewing the progress and application prospect of PDPN.

Objective To understand the needs for and supply of clinical research consultation at the clinical epidemiological unit (CEU) in a general hospital. Methods Data were collected from work records of 2008 of CEU and were analysed. Results There were three faculties and three graduate students in the CEU, who altogether provided 272 consultations in 2008. 147 of the consultants were doctors (54.0%), and 90 were graduate students (33.1%). With regard to the content of consultation, 106 (39. 0%) were for bio-statistical methods, 96 (35. 3%) for project design, 36(13.2%) for paper writing and 24 (8.8%) for others. The professor of the CEU provided more consultation on project design (71/139, 51.1%) than assistant professors (22/151, 19.1%) and graduate students (3/18, 16.7%) (P＜0.01). The assistant professors (66/151, 57.4%) and graduate students (10/18, 55.6%) provided consultation on bio-statistical methods more than the professor (30/139, 21.6%) (P＜0. 01). Conclusion Doctors and graduate students in the general hospital need clinical research consultation service from the CEU. It is necessary and possible to establish a CEU in general hospital to meet the needs of clinical epidemiological consultation. The free consulting policy is effective in improving the accessibility and satisfaction of the consulting service.

Hedgehog (Hh) signaling is critical for embryonic development and in differentiation,proliferation,and maintenance of multiple adult tissues.Deregulation of the Hh pathway is associated with Multiple pathological steps of PDAC(Pancreatic ductal adenocarcinoma).A prominent desmoplastic stromal reaction is the pathological hallmark of PDAC,it contributes to the formation of the hypovascular and hypoxic microenvironment of PDAC.And Hedgehog signaling is one of the most crucial pathways that maintains and activates the stroma.Clinical trials of Hedgehog signaling inhibitors in treatment of PDAC has been conducted,but results have been disappointing.Recently,to undercover the reason of the failure of clinical trial,more work has been done to uncovering the underlying role of stroma in PDAC.

Tumor-associated macrophages (TAMs) exist in the tumor microenvironment,and can be affected by various anticancer treatments and further affect tumor progression.Increasing evidence suggests that many of the clinical antitumor measures can play a unique and effective antitumor effect by regulating the recruitment,polarization and related pro-tumor behavior of macrophages in the tumor microenvironment.Now,tumor microenvironment immune remodeling has become a hot spot in the research of anti-tumor therapy.This paper reviews the related research progress on antitumor effects of TAMs as an therapeutic target.

Objective To explore the diagnostic value and clinical significance of simultaneous detection of AFP,AFU and TSGF in patients with primary hepatic carcinoma(PHC).Methods Serum AFP,AFU and TSGF were detected simultaneously in 62 patients with PHC and 30 controls.Results The levels of AFU and TSGF in primary hepatic carcinoma were all significantly higher than that of controls(P

Objective To observe the anti-shock effect of rapid infusion of 7.5% sodium chloride(NaCl) in dog with hemorrhagic shock. Methods Five mongrel dogs were bled to mean arterial pressure(MAP) of 5.33～6.70kPa, and this pressure was maintained for 1 hour. Each dog received 7.5% NaCl (4ml/kg) intravenously, the infusion time was 2 min. The observation time was 4 hours. Results During the infusion period, the blood pressure was obviously lower than that of the shock period(P

Objective:To study the effects of ozone aging on the color stability of the SY-1 silicone elastomer. Methods :40 SY-1 silicone elastomer samples were prepared and grouped into 4 with 10 in each group. The samples in each group were painted with gouache color, oil pigment and inorganic salt respectively, one group was used as the control. Then the samples were treated with ?=10 -4 % ozone at 10～16 mm/s for 72 h. The color of the samples were measured by 1976 CIE L *a *b * standards of chromatic aberration before and after ozone treatment. The chromatic aberration was expressed as △E=〔△L *)2+(△a *)2+(△b *)2〕 1/2. Results :After 72 hours of ozone aging, △E of the samples in the groups of control, gouache color, oil pigment and inorganic salt was 0.55?0.11, 3.55 ? 0.09, 1.40 ? 0.11 and 1.57 ? 0.07 respectively ;Conclusion:Under the ozone aging condition, the SY-1 silicone elastomers stained with oil pigment and inorganic salt may have better color stability than that with gouache color.

Objective To investigate the action mechanism of Tianqi Yizhi Granules for Alzheimer disease. Methods Ninety SD rats were divided into sham-operation group, model group, positive medicine group, high, medium and low dosage of Tianqi Yizhi Granules groups. SD rats were injected with aggregated amyloid β1-42 protein (Aβ1-42) into their left ventricle to establish AD models. Treatment groups received gavage with Huperzine A or Tianqi Yizhi Granules. The sham-operation group and model group received gavage with the same volume of normal saline. The mitochondrial membrane potential, activity of complex Ⅰ, Ⅱ, Ⅲ and Ⅳ of mitochondrial respiratory chain, enzymatic activity of Na+-K+ATP, energy charge, and space leaning ability were detected. Results Compared with model group, Tianqi Yizhi Granules could significantly improve mitochondrial membrane potential, activity of complex Ⅰ, Ⅲ and Ⅳ of mitochondrial respiratory chain, enzymatic activity of Na+-K+ATP, space leaning ability, and energy metabolism of brain in AD rats. Conclusion Tianqi Yizhi Granules showed mitochondrial protective capacity, and could improve energy metabolism of brain in AD rats, and then improve AD rats’ space learning ability.

OBJECTIVE:To observe the clinical efficacy and safety of Shenfu injection combined with Danshen chuanxiongqin injection in the treatment of chronic pulmonary heart disease patients with heart failure. METHODS:Totally 100 chronic pulmonary heart disease patients with heart failure were randomly divided into observation group and control group. Patients in control group were given routine treatment,including antispasmodic asthma,low-flow oxygen therapy,anti-inflammatory,diuretic strong heart, maintaining the body water,electrolyte balance,vasoactive drugs and dopamine,etc. Patients in observation group were given Shenfu injection 50 ml and Danshen chuanxiongqin injection 10 ml adding into 5% glucose injection 250 ml based on the treatment of control group,iv,once a day. The course of both was 14 d. The clinical data was observed,including clinical efficacy,improve-ment time of signs and symptoms,p(O2),p(CO2),SV,LVEF,LVEDD,LVSD and the incidence of adverse reactions before and after treatment. RESULTS:The total effective rate in observation group was significantly higher than control group,the remission time of cyanosis,slowing time of heart rate and subsided time of swelling were significantly shorter than control group,with signif-icant differences(P<0.05). After treatment,the p(O2),p(CO2),SV,LVEF,LVEDD and LVSD in 2 groups were significantly bet-ter than before,and observation group was better than control group,with significant differences(P<0.05). There were no obvious adverse reactions during treatment. CONCLUSIONS:Based on the treatment,Shenfu injection combined with Danshen chuanxion-gqin injection has better clinical efficacy than routine treatment in the treatment of chronic pulmonary heart disease patients with heart failure,with similar safety.