BACKGROUND:Calcaneal fractures are often accompanied with a height reduction in the calcaneus. Compared to the intra-articular fracture with much specific operation indications, there is no standard to the reduction of calcaneal height that needs a surgery in extra-articular fractures. Therefore, it is necessary to find a more quantitative operation indication. OBJECTIVE:To explore the changes in calcaneus stress distribution along with the varying calcaneal height through finite element analysis. METHODS:A three-dimensional finite element model of the normal ankle was developed. Four finite element models with the calcaneus height decrease in 5, 10, 15 and 20 mm were developed based on the normal ankle model. And the VonMises distribution of the calcaneus, the maximal stress and its location were respectively analyzed. RESULTS AND CONCLUSION:In the normal ankle model, the stress concentration was found in the posterior inner part of the posterior articular surface, the anterior inner part of the posterior articular facet and the calcaneocuboid articular surface. And the maximal stress was 16.608 MPa, which appeared in the posterior inner part of the posterior articular surface. The stress concentration in the calcaneocuboid articular surface disappeared when the calcaneal height decreased, and the maximal stress of the model with the calcaneal height decrease of 5, 10, 15 and 20 mm was 18.325, 19.674, 22.491 and 25.694 MPa, respectively. The results suggest that the VonMises of calcaneus concentrates and increases obviously when the calcaneal height changes. It seems that the calcaneal height should be restored to the normal level. When the reduction of the fracture is difficult, the decrease of the calcaneal height should be limited within 10 mm.

The IR determination of phospholipid content in Semen Zizyphi Spinosae and Fructus Psoraleae, both of which are tonics,was reported for the first time.In this method,using PC as standard sample, chloroform as solvent and the absorption band of P-O-C bond as measurement wavelength,the ab- sorptive degree was linear for concentration in ranging from 0.6mg/ml to 4.0mg/ml.The standard deviation was 0.0682.CV was 1。69%。Compared with the result obtained by colorimetric assay, this method was simpler,its result was more stable.

In this paper 100 cases of renal space-occupying lesions which had been examined before operation by sonography and verified by surgery and pathology were analysed retrospectively. Results showed 99 cases of renal space-occupying lesions and 1 case of retroperitoneal tumor. There were 2 eas-es of false negative and 1 case of false positive for the localization by ultrasound.Nephromas were found to be 92.92%(92/99)totally.in which rnalignant and benign tumors were 86.96%(80/92)and 13.04%(12/92)respectively.5 cases of misdiagnosis and 2 cases of pitfall in qualitative analysis were iden-dried by pathology.The rate of accuracy was 92%(92/100).

HP450 has thecharacteristic of cytochrome P450 and sensitivity to antihistmine drugs.With distinct raiiable regularity in the diverse disease modes of the rat,and some relativity to the development of liver disease,the expression and transcription of the HP450s gene have all changed in the course of the liver cancer. HP450 is possibly regarded as a new index of diagnosing liver cancer and a new target site of preventing and treating liver cancer

Objective To investigate the characteristics of optical coherence tomography (OCT) in eyes with repaired idiopathic macular hole (IMH) after operation and the relation with recovery of visual acuity. Methods The characteristics of OCT images of 24 patients (25 eyes) with repaired IMH after vitrectomy,internal limiting membrane(ILM)peeling and auto-serum healing were analyzed retrospectively. In the patients with IMH, the macular hole was found in 9 eyes at stage Ⅱ, 13 eyes at stage Ⅲ, and 3 eyes at stage Ⅳ. Examinations of best-corrected visual acuity, slit-lamp biomicroscopy with fundus contact lens, fundus photography, fundus fluorescein angiography(FFA) and OCT were performed on the patients 3 to 24 months after surgery. Results OCT images of the repaired IMH were categorized into 3 patterns: U-type (5 eyes) with relative normal foveal contour; V-type (7 eyes) with steep foveal contour;W-type (13 eyes) with foveal defect of neurosensory retina, but without warped hem of retinal hole or cystic formation. Postoperative visual acuities were improved in all of the patients and the best ones were in group U-type. Conclusion Characteristics of OCT images of repaired IMH may be related to the postoperative visual acuity.

With the advent of the cancer stem cell hypothesis,the field of cancer research has experienced a revolution in how we think of and approach cancer. The discovery of "tumor-initiating cell" has offered an explanation for several long-standing conundrums on why tumors behave the way they do to treatment. Despite the great amount of research that has been done in order to understand the molecular aspects of tumors,the prognosis of tumors remains dismal. The slow progress in extending the survival of patients with malignant tumors is very likely due to poor understanding of the cell of origin in these tumors.This review article discusses the progress in our understanding of tumor-initiating cell as the cell of origin in cancers. We review the different proposed mechanisms of how tumor-initiating cell may originate,the molecular mechanisms of cancer initiation and progression, and finally the clinical implications of this research.

Objective To study a simple, safe and effective way in correction of prominent mandibular angle. Methods Curved osteotomy was employed for prominent mandibular angle through intra and extra oral approach with a small incision in 20 cases.Partial masseter resection was performed simutaneously in 5 cases with masseter hypertrophy, buccal fat pads were resected in 3 cases with broad faces, and genioplasty were performed in 3 cases with micrognathia. Nine cases only suffering from prominent mandibular angle were underwent curved osteotomy reconstruction. Results A series of 20 cases was followed up from six months to six years, in which 95 % was satisfactory.Conclusion The advantages of this method are simple, safe and symmetric with better result. It is easy to dissect under periosteum and perform curved osteotomy with less complication, quick recovery, and better contouring.

Purpose:To study the mutual relationships between apoptosis,cell proliferation correlative gene PCNA and tumor suppressor gene P27 Kip1 as well as to investigate if they have something to do with the occurrence,development,and prognosis in esophagus squamous cell carcinoma.Methods:47 cases of primary esophagus squamous cell carcinoma were put into investigative group whose tumor samples from operation resection were studied. 20 cases with normal esophagus cell mucous membrane tissue were put into the control group. Expression level of PCNA,P27 Kip1 was detected by immunohistochemistry method (S-ABC) in both groups. Apoptotic index was detected by TdT mediated deoxyuridylic acid(dUMP)nicking end labeling (TUNEL method) in both groups.Results:①In the group of 47 cases of esophagus squamous cell carcinoma,there were 17 cases of positive expression in P27 Kip1 ,and the positive rate was 36.17% , average proliferation index(PI) was 45.86?19.11%,average apoptotic index is 1.05%?0.59%,ratio of PI/AI is 57.37? 45.17 ,all of which were statistically significant for difference between normal tissue and carcinoma in esophagus squamous cell (P

Objective:To study the feasibility of repair of partial maxillary defect by distraction osteogenesis(DO) in zygoma.Methods:Segmental maxilla- zygoma defect was made in 3 dogs. A submerged DO distractor was anchoraged on the zygoma and maxilla across the defect,the zygoma was distracted with a rate of 1.0 mm/d for ten days,the process of bone formation was examined by X-ray.Results:All dogs were in health condition within the experimental period.New bone formation was observed 2~4 weeks after operation. Complete repair of the defects was observed 8 weeks after the completion of distraction.Conclusion:The partial maxillary defect may be repaired by DO in zygoma.