Objective: To investigate the trends in mortality and life loss of gastric cancer in Wenzhou City, Zhejiang Province from 2014 to 2023, so as to provide the evidence for formulating the prevention and control strategy for gastric cancer. Methods: The surveillance on causes of death data of permanent residents in Wenzhou City were collected through the Wenzhou Chronic Disease Monitoring and Management Information System from 2014 to 2023. The crude mortality of gastric cancer was calculated, and standardized by the data from the Sixth Chinese National Population Census in 2010. The life loss were measured using potential years of life lost (PYLL) and rate of potential years of life lost (PYLLR). The characteristics of mortality and life loss of gastric cancer in different genders and age groups were described. The trends in mortality and PYLLR of gastric cancer were analyzed using the average annual percent change (AAPC). Results: Totally 17 080 deaths were reported due to gastric cancer in Wenzhou City from 2014 to 2023, accounting for 12.58% and ranking third in the order of malignant tumor deaths. The crude mortality of gastric cancer was 20.73/105, and the standardized mortality was 15.22/105, showing decreasing trends (AAPC=-3.311%, -6.470%, both P<0.05). The crude mortality of gastric cancer was 29.22/105 in men and 11.61/105 in women, with standardized mortality rates of 20.81/105 and 8.74/105 (both P<0.05). The crude mortality of gastric cancer appeared a tendency towards a rise with increasing age (P<0.05), reaching the highest rate of 225.88/105 in the group aged 80 to <85 years. The PYLL and PYLLR of gastric cancer were 107 607.50 person-years and 1.37‰. The PYLLR appeared a tendency towards a decline from 2014 to 2023, with AAPC of -6.667% (P<0.05). Conclusions The mortality and PYLLR of gastric cancer in Wenzhou City appeared a tendency towards a decline from 2014 to 2023. Men and the elderly populations were the key groups for the prevention and treatment of gastric cancer.

Objective: To investigate the association between overweight, obesity, central obesity and hypertension, so as to provide the basis for formulating targeted hypertension prevention and control strategies. Methods: Permanent residents aged ≥18 years were selected in Wenzhou City, Zhejiang Province from June 2023 to August 2024 by a multistage cluster random sampling method. Data on demographic information, lifestyle, height, weight, waist circumference (WC), blood pressure, and blood biochemical indicators were collected through questionnaire surveys, physical examinations, and laboratory tests. The prevalence of hypertension was calculated and standardized using the data of the Sixth National Population Census in 2010. Body mass index (BMI) was calculated to determine overweight and obesity, while WC was used to identify central obesity. The association between overweight, obesity, central obesity and hypertension were analyzed using multivariable logistic regression models. Results: A total of 38 593 residents were surveyed, including 19 481 (50.48%) males and 19 112 (49.52%) females. The median age was 46.00 (interquartile range, 26.00) years. The rates of overweight, obesity, and central obesity were 32.74% (12 634 individuals), 10.27% (3 963 individuals), and 27.87% (10 755 individuals), respectively. There were 11 813 cases of hypertension, with a prevalence and standardized prevalence of 30.61% and 24.41%, respectively. Multivariable logistic regression analysis showed that after adjusting for demographic information, lifestyle, diabetes and dyslipidemia, the likelihood of hypertension in the overweight and obesity groups was 1.927 (95%CI: 1.815-2.045) times and 3.724 (95%CI: 3.404-4.073) times that of the normal BMI group, respectively. The likelihood of hypertension in the central obesity group was 2.346 (95%CI: 2.214-2.486) times that of the normal WC group. The likelihood of hypertension in the central obesity only, overweight only, overweight with central obesity, obesity only and obesity with central obesity groups was 1.586 (95%CI: 1.391-1.809), 1.704 (95%CI: 1.582-1.835), 2.433 (95%CI: 2.254-2.626), 1.768 (95%CI: 1.424-2.194), and 4.466 (95%CI: 4.053-4.921) times that of the normal BMI and WC group, respectively. Conclusions Overweight, obesity and central obesity were all associated with hypertension among adult residents. The highest likelihood of hypertension was observed among adult residents with both general obesity and central obesity.

Background::Findings on the association of genetic factors and colorectal cancer (CRC) survival are limited and inconsistent, and revealing the mechanism underlying their prognostic roles is of great importance. This study aimed to explore the relationship between functional genetic variations and the prognosis of CRC and further reveal the possible mechanism.Methods::We first systematically performed expression quantitative trait locus (eQTL) analysis using The Cancer Genome Atlas (TCGA) dataset. Then, the Kaplan-Meier analysis was used to filter out the survival-related eQTL target genes of CRC patients in two public datasets (TCGA and GSE39582 dataset from the Gene Expression Omnibus database). The seven most potentially functional eQTL single nucleotide polymorphisms (SNPs) associated with six survival-related eQTL target genes were genotyped in 907 Chinese CRC patients with clinical prognosis data. The regulatory mechanism of the survival-related SNP was further confirmed by functional experiments.Results::The rs71630754 regulating the expression of endoplasmic reticulum aminopeptidase 1 ( ERAP1) was significantly associated with the prognosis of CRC (additive model, hazard ratio [HR]: 1.43, 95% confidence interval [CI]: 1.08-1.88, P = 0.012). The results of dual-luciferase reporter assay and electrophoretic mobility shift assay showed that the A allele of the rs71630754 could increase the binding of transcription factor 3 (TCF3) and subsequently reduce the expression of ERAP1. The results of bioinformatic analysis showed that lower expression of ERAP1 could affect the tumor immune microenvironment and was significantly associated with severe survival outcomes. Conclusion::The rs71630754 could influence the prognosis of CRC patients by regulating the expression of the immune-related gene ERAP1. Trial Registration::No. NCT00454519 (https://clinicaltrials.gov/)

Objective: To analyze the trends in mortality of liver cancer in Wenzhou City, Zhejiang Province from 2014 to 2022, so as to provide the evidence for improving liver cancer control measures. Methods: Data of liver cancer mortality in Wenzhou City from 2014 to 2022 were collected from Wenzhou Chronic Disease Monitoring Information System. The crude mortality were estimated and standardized by the national population census data in China in 2010, and the trends in mortality of liver cancer were analyzed with average annual percent change (AAPC). Results: There were 22 033 liver cancer deaths from 2014 to 2022, accounting for 18.08% of malignant tumor deaths and ranking the second in malignant tumor deaths. The crude mortality of liver cancer was 30.00/105 and the standardized mortality was 24.32/105, both showing decreasing trends (AAPC=-2.812% and -5.742%, both P<0.05). The standardized mortality of liver cancer were higher in men than in women (36.66/105 vs. 11.21/105, P<0.05), both showing decreasing trends (AAPC=-5.702% and -5.521%, both P<0.05). The crude mortality of liver cancer appeared a tendency towards a rise with age (P<0.05), with the highest crude mortality in the group aged 80 to 84 years, reaching 145.12/105. The crude mortality of liver cancer showed a tendency towards a decline among residents aged under 15 years, 15 to 44 years, 45 to 64 years and 65 years and above (AAPC=-20.311%, -6.569%, -7.408% and -3.177%, all P<0.05). Conclusions The mortality of liver cancer showed a tendency towards a decline in Wenzhou City from 2014 to 2022. Men and the elderly were high-risk groups for liver cancer deaths, and prevention should be strengthened based on risk factors.

Objective To understand the use of the corresponding scenarios of digital transformation of"convenient medical service"in Shanghai municipal hospital outpatient department from the perspective of patients,and to provide relevant suggestions for promoting digital transformation.Methods A questionnaire survey was conducted among outpatients in Shanghai municipal hospitals to understand the use of digital transformation scenarios and their cognition of digital transformation,and the hypothesis was verified from the perspectives of technology,environment and social factors through the Technology Acceptance Model.Results A total of 4 285 valid questionnaires were collected.The top three scenarios used in outpatient digital transformation are"Precise Appointment"(71.18％),"Convenient Payment"(67.47％)and"Electronic Ticket"(48.87％).Patients'positive experience of friendly interface,stable system,recommendations from relatives and friends and social media significantly and positively influenced their perceptions of technical usability and usefulness.Positive feelings of technical usability and usefulness also encouraged patients to accept and promote digital transformation more actively(P＜0.001).Conclusion The use scenario of patients'outpatient digital transformation is closer to the core medical treatment process.The construction of relevant digital scenarios requires the joint promotion of medical institutions and society.The age-appropriate process transformation for elderly patients needs to reflect humanistic care.

Objective To understand the use of the corresponding scenarios of digital transformation of"convenient medical service"in Shanghai municipal hospital outpatient department from the perspective of patients,and to provide relevant suggestions for promoting digital transformation.Methods A questionnaire survey was conducted among outpatients in Shanghai municipal hospitals to understand the use of digital transformation scenarios and their cognition of digital transformation,and the hypothesis was verified from the perspectives of technology,environment and social factors through the Technology Acceptance Model.Results A total of 4 285 valid questionnaires were collected.The top three scenarios used in outpatient digital transformation are"Precise Appointment"(71.18％),"Convenient Payment"(67.47％)and"Electronic Ticket"(48.87％).Patients'positive experience of friendly interface,stable system,recommendations from relatives and friends and social media significantly and positively influenced their perceptions of technical usability and usefulness.Positive feelings of technical usability and usefulness also encouraged patients to accept and promote digital transformation more actively(P＜0.001).Conclusion The use scenario of patients'outpatient digital transformation is closer to the core medical treatment process.The construction of relevant digital scenarios requires the joint promotion of medical institutions and society.The age-appropriate process transformation for elderly patients needs to reflect humanistic care.

Objective To understand the use of the corresponding scenarios of digital transformation of"convenient medical service"in Shanghai municipal hospital outpatient department from the perspective of patients,and to provide relevant suggestions for promoting digital transformation.Methods A questionnaire survey was conducted among outpatients in Shanghai municipal hospitals to understand the use of digital transformation scenarios and their cognition of digital transformation,and the hypothesis was verified from the perspectives of technology,environment and social factors through the Technology Acceptance Model.Results A total of 4 285 valid questionnaires were collected.The top three scenarios used in outpatient digital transformation are"Precise Appointment"(71.18％),"Convenient Payment"(67.47％)and"Electronic Ticket"(48.87％).Patients'positive experience of friendly interface,stable system,recommendations from relatives and friends and social media significantly and positively influenced their perceptions of technical usability and usefulness.Positive feelings of technical usability and usefulness also encouraged patients to accept and promote digital transformation more actively(P＜0.001).Conclusion The use scenario of patients'outpatient digital transformation is closer to the core medical treatment process.The construction of relevant digital scenarios requires the joint promotion of medical institutions and society.The age-appropriate process transformation for elderly patients needs to reflect humanistic care.

Objective To understand the use of the corresponding scenarios of digital transformation of"convenient medical service"in Shanghai municipal hospital outpatient department from the perspective of patients,and to provide relevant suggestions for promoting digital transformation.Methods A questionnaire survey was conducted among outpatients in Shanghai municipal hospitals to understand the use of digital transformation scenarios and their cognition of digital transformation,and the hypothesis was verified from the perspectives of technology,environment and social factors through the Technology Acceptance Model.Results A total of 4 285 valid questionnaires were collected.The top three scenarios used in outpatient digital transformation are"Precise Appointment"(71.18％),"Convenient Payment"(67.47％)and"Electronic Ticket"(48.87％).Patients'positive experience of friendly interface,stable system,recommendations from relatives and friends and social media significantly and positively influenced their perceptions of technical usability and usefulness.Positive feelings of technical usability and usefulness also encouraged patients to accept and promote digital transformation more actively(P＜0.001).Conclusion The use scenario of patients'outpatient digital transformation is closer to the core medical treatment process.The construction of relevant digital scenarios requires the joint promotion of medical institutions and society.The age-appropriate process transformation for elderly patients needs to reflect humanistic care.

Objective To understand the use of the corresponding scenarios of digital transformation of"convenient medical service"in Shanghai municipal hospital outpatient department from the perspective of patients,and to provide relevant suggestions for promoting digital transformation.Methods A questionnaire survey was conducted among outpatients in Shanghai municipal hospitals to understand the use of digital transformation scenarios and their cognition of digital transformation,and the hypothesis was verified from the perspectives of technology,environment and social factors through the Technology Acceptance Model.Results A total of 4 285 valid questionnaires were collected.The top three scenarios used in outpatient digital transformation are"Precise Appointment"(71.18％),"Convenient Payment"(67.47％)and"Electronic Ticket"(48.87％).Patients'positive experience of friendly interface,stable system,recommendations from relatives and friends and social media significantly and positively influenced their perceptions of technical usability and usefulness.Positive feelings of technical usability and usefulness also encouraged patients to accept and promote digital transformation more actively(P＜0.001).Conclusion The use scenario of patients'outpatient digital transformation is closer to the core medical treatment process.The construction of relevant digital scenarios requires the joint promotion of medical institutions and society.The age-appropriate process transformation for elderly patients needs to reflect humanistic care.

Objective To understand the use of the corresponding scenarios of digital transformation of"convenient medical service"in Shanghai municipal hospital outpatient department from the perspective of patients,and to provide relevant suggestions for promoting digital transformation.Methods A questionnaire survey was conducted among outpatients in Shanghai municipal hospitals to understand the use of digital transformation scenarios and their cognition of digital transformation,and the hypothesis was verified from the perspectives of technology,environment and social factors through the Technology Acceptance Model.Results A total of 4 285 valid questionnaires were collected.The top three scenarios used in outpatient digital transformation are"Precise Appointment"(71.18％),"Convenient Payment"(67.47％)and"Electronic Ticket"(48.87％).Patients'positive experience of friendly interface,stable system,recommendations from relatives and friends and social media significantly and positively influenced their perceptions of technical usability and usefulness.Positive feelings of technical usability and usefulness also encouraged patients to accept and promote digital transformation more actively(P＜0.001).Conclusion The use scenario of patients'outpatient digital transformation is closer to the core medical treatment process.The construction of relevant digital scenarios requires the joint promotion of medical institutions and society.The age-appropriate process transformation for elderly patients needs to reflect humanistic care.