Kidney damage caused by inappropriate use of some chinese herb drugs are quite common in our country. This review give a brief introduction of those reports concened, which include the most frequently used herb drugs of Aristolochia and their main components, the pharmacokinetic of Aristolochic acid, the different clinical manifestation of chinese herb nephropathy and the possible mechanism of the nephrotoxicity of Aristolochic acid.

A retrospective analysis of 3 patients with nasal sinus foreign body caused by debris flow admitted to our department. All of the three patients showed foreign odor and mucopurulent discharge in nasal cavity after the debris flow blast injury. CT examination found high density soft tissue shadow or calcification in the nasal sinus. All the diagnoses were nasal sinus foreign body in three patients. The nasal sinus foreign bodies was dislodged through endoscopic sinus surgery. Three patients are all well-healed.
Adult ; Female ; Foreign Bodies ; etiology ; Humans ; Male ; Paranasal Sinuses

Objective To examine the concurrent validity of Peabody'S developmental motor scale number 2(PDMS-2)and Gesell's developmental scales with 1 2 to 30 month-old children with cerebral palsy (CP)and to assess the value of PDMS-2 in measuring motor function in children with CP.Methods Eighty-four children with CP aged 12 to 30 months were assessed with both PDMS-2 and Gesell's developmental scales.The correlation between PDMS-2 gross motor quotients and Gesell gross motor developmental quotients,and be-tween PDMS-2 fine motor quotients and Gesell fine motor developmental quotients were compared using Spearman rank correlation coefficients. Results The correlation coefficient between PDMS-2 gross motor quo-tient and the Gesell gross motor developmental quotient was 0.89.Between PDMS-2 fine motor quotient and Gesell's fine motor developmental quotient it was 0.87.The concurrent validities were 0.28 and 0.42 respec-tively. Conclusion PDMS-2 gross motor quotient and Gesell's gross motor developmental quotient are highly correlated,as are PDM S-2 fine motor quotient and Gesell's fine motor developmental quotient.The concurrent validities were between classifications using the PDMS-2 gross motor quotient and Gesell's gross motor develop- mental quotient were weakly correlated,but there was moderate correlation between PDM S-2 fine motor quotientsand Gesell fine gross developmental quotients.There may be limitations in assessing motor function children aged12 to 30 months with cerebral palsy using PDMS-2.

Objective To investigate the incidence rate of auditory nerve way injury in children with cerebral palsy (CP) and the relationship with sexes, CP types and risk factors.MethodsThe clinic data of 963 children with CP were reviewed to find out the incidence rate of auditory nerve way injury in CP children and the relationship with sexes, CP types and risk factors.ResultsIn 963 CP children, the incidence rate of auditory nerve way injury was 24.5% (236/963), there was no sexes difference ( P>0.05), but there was a significant difference among different CP types ( P<0.05), athetosis and mixed CP had higher incidence rate ( P<0.01). Furthermore, pathological jaundice was high risk factor ( OR=2.0279, 95%CI:1.483～2.774).ConclusionCP children are often complicated with auditory nerve way injury, it not relate with sexes, but with CP type, athetosis and mixed CP have a higher incidence rate of auditory nerve way injury, and the pathological jaundice is a high risk factors.

Objective To analyze the relationship between intelligence development and clinical types and high-risk factors in the children with cerebral palsy (CP).Methods 363 CP children were tested using Gesell Developmental Scale (GDS), the relationship between intelligence development delay and clinical types and high-risk factors was analyzed.Results There was a significant relation between asyphxia, pathologic jaundice and intelligence development delay of CP children. The rate of intelligence development delay in athetotic and mixed type CP was significantly higher than the spastic type ( P<0.01).Conclusion Asyphxia and pathologic jaundice are the high-risk factors inducing intelligence development delay, and there is a relationship between intelligence development delay and clinical type of CP.

Objective To observe the effect of traditional Chinese medicine vapor bath combined with function training on children with spastic cerebral palsy(CP).Methods 84 cases with spastic CP were divided into the treatment group(39 cases treated by traditional Chinese medicine vapor bath combined with function training treatment)and control group(43 cases treated with function training treatment mainly).Results The total effect rates were 84.6% in the treatment group and 65.1% in the control group with a significant difference between two groups(P<0.05).The muscle tension of the children in the treatment group was lower than that in the control group(P<0.05).Conclusion The traditional Chinese medicine vapor bath can reduce the muscle tension of children with spastic CP.

ObjectiveTo investigate the correlation between the Gesell Developmental Scale and the Peabody Developmental Motor Scale-2(PDMS-2) in children with zentrale koordination storung(ZKS).Methods657 children with ZKS, aged 3 to 8 months, administered both the Gesell Developmental Scales and the PDMS-2. The correlation coefficients of the Gesell gross motor developmental age and the PDMS-2 gross motor subscale age-equivalent scores, the Gesell fine motor developmental age and the PDMS-2 fine motor subscale age-equivalent scores, the Gesell gross motor Developmental Quotient(G-GMDQ) and the PDMS-2 Gross Motor Quotient (P-GMDQ), the Gesell fine motor DQ(G-FMDQ) and the PDMS-2 Fine Motor Quotient(P-FMDQ) was compared by the Spearman rank correlation coefficient.ResultsThe correlation coefficients of the Gesell motor developmental age and the PDMS-2 motor subscale age-equivalent scores were 0.755 to 0.845(P<0.01). The correlation coefficients of G-GMDQ and P-GMDQ, G-FMDQ and P-FMDQ were 0.645 and 0.677(P<0.01) respectively.ConclusionThe concurrent validity were high correlation between the PDMS-2 gross motor subscale age-equivalent scores and the Gesell gross motor developmental age, the PDMS-2 fine motor subscale age-equivalent scores and the Gesell fine motor developmental age, and P-FMDQ and the G-FMDQ. The concurrent validity was moderate correlation between P-GMDQ and G-GMDQ.

Objective To explore risk factors for coronary artery aneurysms (CAA) in children with Kawasaki disease (KD),and reduce the rate of serious sequelae of cardiovascular diseases.Methods All the patients were diagnosed as KD in Children’s Hospital Affiliated to Medical College of Zhejiang University from January 2009 to January 2014.A total of 679 cases was included,and 42 with concurrent CAA,181 with concurrent coronary artery expansion (CAD),and 456 without coronary artery damage cases (non-coronary artery lesion,NCAL).Coronary artery damage was related to factors such as gender,age,fever,white blood cell count (WBC),hemoglobin (Hb),platelet count (PLT),erythrocyte sedimentation rate (ESR),C-reactive protein (CRP),alanine aminotransferase,serum potassium,plasma amino terminal brain natriuretic peptide precursor (NT-proBNP),and acrylic ball resistance.SPSS 18.0 software package was used for risk factor analysis.Qualitative data using chi-square test,was used to analyze the high risk factors of CAA group,and logistic multivariate regression analysis was also used.Results Chi-square test showed that male,with febrile days ＞ 14 d,NT-proBNP ≥ 1 000 ng/L,immunoglobulin resistance was more likely to have KD concurrent CAA (P ＜ 0.05).Multiple Logistic regression analysis showed that male [OR =4.092,95％ CI (1.514,11.060),P =0.004],febrile days ＞14 d [OR =12.436,95％ CI (4.599,33.631),P =0.000],NT-proBNP≥ 1 000 ng/L [OR =3.305,95％ CI (1.401,7.794),P =0.005],and immunoglobulin resistance [OR =3.842,95 ％ CI (1.562,9.453),P =0.000] were independent risk factors for KD concurrent CAA.Conclusions Male children,febrile days ＞ 14 d,NT-proBNP≥ 1 000 ng/L,and immunoglobulin resistance were independent risk factors of CAA.

Objective To investigate the expressions of RhoB and E-cadherin in non-small-cell lung cancer (NSCLC), and their clinical significances thereof. Methods Immunohistochemical staining was applied to detect expres-sions of RhoB and E-cadherin in 116 samples of NSCLC (NSCLC group) and 116 samples of normal lung tissues (control group). Correlations of expressions of RhoB and E-cadherin to clinical pathological parameters and prognosis were analyzed in two groups. Results The expression intensities of RhoB and E-cadherin were significantly lower in NSCLC group than those in control group (57.76%vs 87.07%,54.31%vs 85.34%,P＜0.01). There were significant differences in the expres-sion of RhoB between different pathological types, differentiation and lymph node metastasis in NSCLC group. There were significant differences in the expression of E-cadherin between different TNM stages, differentiation and lymph node metas-tasis in NSCLC group. The expression of RhoB was positively correlated with the expression of E-cadherin ( r=0.503,P＜0.01). The 3-year survival rates were significantly higher in patients with high expression of RhoB (83.93%) than those in pa-tients with low expression of RhoB (40.00%, Log-rank χ2=18.992,P＜0.01). The 3-year survival rates were significantly higher in patients with high expression of E-cadherin (85.11%) than those in patients with low expression of E-cadherin (44.93%, Log-rankχ2=16.680,P＜0.01). Further multivariate analysis suggested that both lower expressions of RhoB and E-cadherin and lymph node metastasis were prognostic indicators for NSCLC (P＜0.001). Conclusion The expressions of RhoB and E-cadherin showed a good correlation in NSCLC. Detecting the expression of RhoB combined with E-cadherin may give a clue on clinicopathological features and prognosis in patients with NSCLC.

Objective To establish the normal reference ranges of clinical pathology for Beagle dogs in the Good Laboratory Practice ( GLP ) system.Method Sixteen biochemical indexes , seventeen hematological indexs and three coagulation function indexes of 117 Beagle dogs were detected , and the mean value of each index and the normal reference ranges were calculated and compared .Results Only alkaline phosphatase ( ALP ) from the biochemical items was significantly different between males and females (P<0.01),which was higher among males than among females .Three in-dexes of hematology were significantly different between males and females (P<0.01),with red blood cell(RBC), hemo-globin(HGB)and hematocrit(HCT)lower among males than among females.The coagulation function items were not signif-icantly different between the two sexes .Conclusion Some indexes of clinical pathology were significantly different between males and females , which should be considered during statistic analysis on toxicity .Our study has established the normal reference range of clinical pathology for Beagle dogs in the GLP system , which provides reference for toxicity tests .