AIM: To observe the efficacy of ketosteril in treatm en t of chronic renal failure with high level of plasma Cys-C. METHODS: 60 patients with chronic renal failure were randomly divided into treatmen t group and control group. The control group was adopted a low protein and low p hosphorum diet and correcting symptoms; the treatment group, based on the therap y of the control group, was given ketosteril; 30 healthy subjects were used as t he normal control to observe changes of Cys-C, Scr, TC, HB, and HDL before and after the treatment. RESULTS: The levels of Cys-C and Scr decre ased after the administration of ketosteril (P