ObjectiveTo evaluate the clinical effects of oral administration of itopride prior to capsule endoscopy on bowel preparation.MethodsA total of 40 patients who underwent capsule endoseopy from April,2010 to April,2011 were randomly assigned to the medication group and the control group (n =20 per group).The medication group took itopride on the day before capsule endoscopy.The two groups underwent the same procedure for bowel preparation.Clearance,gastric transit and intestinal transit of capsule endoscope,lesion detection rates were compared between the two groups.Results Bowel preparation of high quality in the medication group was 80％ (16/20),significantly higher than that (45％,9/20) in the control group (P ＜ 0.05 ).The mean gastric and intestinal transit times in the medication group were 31 min and 251 min,respectively,significantly shorter than those in the control group (P ＜ 0.05).While lesion detection rate in the medication group (60％,12/20) was significantly higher than that of the control (40％,8/20) (P ＜ 0.05).ConclusionOral itopride is of better clinical value for capsule endoscopy preparation.