OBJECTIVE:To prospectively investigate the effects of enalapril in decreasing ACE activity,renal function protection in diabetic nephropathy(DN)patients and prevention of deterioration from DN METHODS:62 DN patients were divided into two groups,31 in each group,the sex,age,disease duration and condition were comparable In treatment group,patients received enalapril 10mg/d in addition to routine anti-hyperglycemic and anti-hypertensive agents,in control group,patients had only routine treatment The observation lasted 18～36 months(mean 26 months) The BP,blood sugar and renal functions were compared between two groups before and after treatment RESULTS:In treatment group,blood sugar,BP and renal functions were significantly improved after treatment of enalapril(P0 05) CONCLUSION:Enalapril can lower ACE activity and protect the renal function,these effects do not depend on it’s anti-hypertension result

BACKGROUND:Maxilary posterior tooth defects can be repaired using the dental implant. However, implantation accuracy is not ensured by traditional plaster models used as implant template, which leads to the incidence of complications,andaffectsthe repair effects.
OBJECTIVE:To study application effects of surgical guide plates designed using the computer aided design (CAD)/computer aided manufacturing (CAM) technology for the repair of maxilary posterior tooth defects.
METHODS:Implant treatment was performed in 30 patients with maxilary posterior tooth defects. Surgical guide plate was made using the CAD/CAM technology after CT scan of the jaw bone. The repair was conducted with guideplateassistant. The deviation between the virtual and actual implant position was measured after implantation. The clinical repair effects and periodontal tissues were observed during the 12-month folow-up.
RESULTS AND CONCLUSION:Thirty-sixCAD/CAM surgical guide plates in 30 patients werestabilized after implantation. Thirty-six implants were emplaced precisely with the assist of the surgical guide plates. There was no any problem during the process of implantation. The deviation of the head between the virtual and actual implant position was very smal, which did not affect the accuracy of implant placement. Before and 6 and 12 months after the repair, gingival crevicular fluid, tumor necrosis factor-α, and sulcus bleeding index were not obviously changed in the patients. Our results suggest that the implant head deviation and angle deviation appearduring the repair process of maxilary posterior tooth defects using CAD/CAM surgical guide for dental implants;however, the implantation accuracy is not affected. The repair effect is ideal and periodontal tissue is in good status after implantation.

BACKGROUND:Targis/composite fiber is a new type of non-metalic repair material that has good hardness and strength, but it is rarely reported on its application in the repair of young permanent tooth defects.
OBJECTIVE:To investigate the clinical effect of Targis/composite fiber in repairing young permanent tooth defects.
METHODS:Sixty cases of young permanent teeth defects 10-17 years of age were enroled, including 27 males and 33 females. Al cases were subjected to Targis/composite fiber repairing. After 36 months of folow-up, alkaline phosphatase level, probing depth, gingival sulcus bleeding index, tooth mobility, plaque index, gingival crevicular fluid volume and aspartate aminotransferase level in patients were detected; the integrity and edge of dental prosthesis and the color matching.
RESULTS AND CONCLUSION:After 36 months, the alkaline phosphatase level in the patients had no significant changes (P> 0.05), but the probing depth, gingival sulcus bleeding index, tooth mobility, plaque index, gingival crevicular fluid volume and aspartate aminot ransferase level were decreased significantly compared with those before repair (P< 0.05). Additionaly, there were two cases of incomplete dental prosthesis, six of color mismatching, andtwo of unsealed prosthesis edge. These findings indicate that the Targis/composite fiber for repairing young permanent tooth defects has good histocom patibility maintains periodontal health in good condition, is a kind of ideal repair materials.

BACKGROUND:Dental implantation in maxilary esthetic zone is difficult to achieve desired outcomes.
OBJECTIVE:To observe the feasibility of digital rapid prototyping implant template for anterior implantation.
METHODS: Eighty patients scheduled to receive anterior implant treatment were enroled. According to the wishes of patients, they were divided into two groups, with 40 cases in each group, and were given routine implant treatment (control group) and digital rapid prototyping template-aided dental restoration (observation group). After implantation, the X-axis, Y-axis and Z-axis errors of the two groups were measured, and the patients were folowed up for 12 months.
RESULTS AND CONCLUSION:After implantation, the errors of X, Y and Z axes in the observation group was significantly lower than those in the control group (P< 0.05); at 24 hours after implantation, patients in the two groups showed good appearance of the anterior tooth with no dental prosthesis loosing. Imaging examinations in the two groups showed no obvious bone resorption. These findings indicate that the aid therapy using digital rapid prototyping can obtain satisfactory therapeutic effect on anterior tooth restoration in the maxilary esthetic zone and precisely localize the dental implantation site.

Nasal supernumerary teeth and additional dental cyst is a common disease in Department of ENT and Department of Stomatology. In reported diseases, patients with a variety of additional teeth appeared in differ ent parts have varied clinical manifestations. Because of no obvious early symptoms, it is more difficult to diagnose, but CT examination in corresponding site can make it easy to diagnose the maxillary sinus and dentigerous cyst diagnosis. Operation is an effective method to cure the disease. Operation is simple, but the defect and tooth cavity after operation is one unavoidable problem for ENT doctor. In relevant literature it can be seen that the disease has a genetic tendency.
Child ; Dentigerous Cyst ; Humans ; Male ; Nasal Cavity ; Nose Diseases ; Tooth, Supernumerary

Objective To study the observation and nursing for exercise-induced fatigue by thread-burying in acupoint. Methods 41 athletes-in-training were treated by thread-burying in acu-point for 2 courses of treatment, choosing main acupointa such as Guan yuan, Shen yu, Pi yu, Ming men,Zu sanli, San yinjiao. Then the changes of athletes' training and hemoglobin were observed. Results After two courses of treatment, athletes' quality of sleep, mental condition in the morning, diet, desire to train, physical fitness, training quality and concentration improved siguificantly.Level of hemoglobin in-creased distinctly. Conclusions The treatment of thread-burying in acupoint could improve sport fa-tigue. Combination with Chinese and western integrative medicine, dialectical treatment, emotion and diet nurse, western integral appraisal procedure to observe and asepsis operation played a positive part in the recovery from sport fatigue.

Objective To explore the effects of two lubricants on skin preparation from donor site in patients with skin flap transplantation. Methods According to digit number table, 83 patients undergoing wound repair using modified fascia flap were divided into observation group (n=41) and control group (n=42). The former group were treated with Johnson K-Y Lubricant, while the latter with talcum powder. The two groups were compared in terms of the skin flap quality from donor site, pain degree and number of bacteria before and after transplantation. Results There was no significant difference in bacteria number before and after transplantation in the two groups (P>0.05), but the difference between the groups was significant (P<0.01). The flap preparation quality in the observation group was significantly better than that of control group and the pain degree was significantly lower than that of observation group. Conclusion Johnson K-Y Lubricant can significantly improve flap preparation quality and reduce pain.

OBJECTIVE:To investigate the clinical characteristics and gene polymorphism of oxcarbazepine (OXC)- induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). METHODS:Retrieved from CNKI,Wanfang,VIP, PubMed,EMBase,SpringerLink and other databases,case reports about OXC-induced severe ADR were summarized and ana-lyzed. RESULTS:Twelve literatures were collected,and 13 case reports about OXC-induced SJS/TEN were obtained. Male had more OXC-induced severe skin ADR than female. ADR mostly occurred during 1-14 d after medication. All patients were cured with treatment of glucocorticoid and antiallergy,without death case. Genotyping for 8 patients were performed and 6 of them showed the presence of HLA-B*1502 allele. While HLA-B alleles of 2 patients were HLA-B*1518/B*4001,which was the variation of HLA-B*1502. CONCLUSIONS:OXC-induced ADR should be monitored closely. Great importance should be attached to patient education and follow-up program. HLA-B*1502 gene detection should be performed to guide rational use of OXC and optimize clini-cal drug use plan.

Objective To investigate the expression of β-catenin and Oct-4 in colonal carcinoma and explore the relationship with recurrence and metastasis after operation. MethodsImmunohistochemical analysis was used to evaluate the expression of β-catenin and Oct-4.The correlation of β-catenin and Oct-4 expression with tumor cell differentiation,T stage,N stage and metastasis was analyzed.The gene expression of Oct-4 was examined by RT-PCR in 20 frozen tumor tissues and normal tissues adjacent to tumor.Results Thirty-five patients had metastasis. The positive rates of β-catenin and Oct-4 expression were significantly higher in metastasis group than in the non-metastasis group (65.71％ vs 31.11％,51.43 ％vs 13.33 ％,x2 =9.843,P =0.002,x2 =13.605,P =0.001).Expression of β-catenin and Oct-4 was not associated with differentiation,T stage or N stage.The positive expression rate of Oct-4 in colonal carcinoma tissues was significantly higher than that in normal tissues.Metastatic rates in patients with positive expression of β-catenin and Oct-4 was higher than that in negative expression.The survival analysis showed that time of metastasis was significantly different in two groups of patients (P ＜0.05).Conclusion The expression of β-catenin and Oct-4 in tumor tissues is related to metastasis of colonal cancer after surgery and might be used to predict metastasis of colonal cancer after operation.

Objective To create a new drying surgical instruments drying cabinet for the drying equipment with some technical short-comings and without widely used. Methods The air cleanliness,temperature and speed of special properties in the process of drying surgical instruments were study to create a new technology of drying cabinet for surgical instruments with a low cost,advanced features and the maneu-verability. Results A new type of dry prototype for surgical instruments was successfully developed and tested with heating and drying,the average heating time and the shortest processing time under 70 ℃ were 5. 1 min and 15. 6 min,respectively,the average heating time and the shortest processing time under 90℃ were 7. 8 min and 14. 2 min,respectively,which has more advantages than traditional drying equipment. Conclusion The new surgical instruments drying cabinet has a high application value and good prospect of industrialization,which can be the basic equipment for CSSD and operating departments of hospital.