Objective:To evaluate the clinical efficacy and analysis influence factors on treatment of the aged COPD with acute respiratory failure by using harmless bi-level positive airway pressure. Method:Twenty-five patients who were identified the aged COPD with acute respiratory failure were divided into two groups randomly:13 in treatment group in which BiPAP was used in addition of conventional treatment;12 in control group in which nasal catheter oxygen inhalation was used. The change of the arterial blood gas and the clinical performance were observed before and 2 hours、72 hours 、120hours after treatment. Result: It is confirmed that the BiPAP can raise PaO2, lower PaCO2, improve PH,HR and R(P

Primary open angle glaucoma (POAG) is a complex and heterogeneous neurodegenerative disease caused by genetic and environmental factors,and it is also one of the leading causes of irreversible blindness worldwide.Recent molecular genetic studies revealed that numbers of susceptible gene variants are associated with POAG,and the researching technology includes genome wide association study and whole exon sequence.Studies of POAG families discovered 16 loci linked to the disease.To date,three genes were reported to be the causative genes of POAG,they are these studies MYOC,OPTN and WDR36.Other causative or presumably causative genes are thought to contribute to POAG,such as NTF4 and TBK1.Genetic factor for the path ogenesis POAG is being widely concerned,and provides a solid foundation for genetic research and gene therapy of this disease.In this paper,we reviewed a comprehensive discussion of the genetics and research strategies of POAG.

Objective To explore the clinical values of the serum homocysteine (Hcy) and platelet aggregation rate in type 2 dia‐betes patient with cerebral infarction .Methods Totally 65 cases of type 2 diabetes patients with cerebral infarction ,55 simple type 2 diabetes patients and 50 cases who took health examination were enrolled in the study .The serum homocysteine and platelet ag‐gregation rate were detected ,the blood pressure ,weight and height of the patients were measured .The multi‐factor Logistic regres‐sion analysis was used to detecting the risk factors in type 2 diabetes patients with cerebral infarction .Results The serum homo‐cysteine level and platelet aggregation rate were significantly higher in diabetes patients with cerebral infarction than those simple diabetes patients or healthy group (P< 0 .05) .The levels of serum homocysteine and platelet aggregation rate were positively corre‐lated with the severity of diabetes patients with cerebral infarction .Conclusion Serum homocysteine and platelet aggregation rate are much higher in type 2 diabetes patients with cerebral infarction ,which indicated that we can predict the process of the cerebro‐vascular disease through detecting the serum homocysteine and platelet aggregation rate .

OBJECTIVE: To compare safety and efficacy between anterior cervical decompression and fusion procedures as well as compound titanium rete implantation for the treatment of cervical spondylotic myelopathy using Meta analysis. DATA SOURCE: The relative articles were retrieved from Chinese Biomedical Literature Database (CBM) from January 1998 to December 2008, CNKI from January 1994 to December 2008, and VIP from January 1989 to December 2008. DATA SELECTION: A clinically randomized controlled study was used to evaluate safety and efficacy between anterior cervical decompression and fusion procedures as well as compound titanium rete implantation for the treatment of cervical spondylotic myelopathy. Control or vertebroplasty was excluded. MAIN OUTCOME MEASURES: JOA score, complication, and bone fusion rate. RESULTS: Six clinically control studies were included in the final analysis containing 443 patients. Among the patients, 190 cases were treated with anterior cervical decompression and fusion procedures alone, and 253 with anterior cervical decompression and fusion procedures as well as compound titanium rete implantation. All the 6 controls were performed with Meta analysis. ① Efficacy of anterior cervical decompression and fusion procedures as well as compound titanium rete implantation was superior to that of anterior cervical decompression and fusion procedures [OR=2.30, 95%, CI (1.32, 4.01), P

Objective;To examine the correlation between A-type personality and time management disposition of normal college Students.Methods;Time Management Disposition Scale and the Scale of A-type Personality were administered to a sample of 526 college students.Results;Analysis showed significant positive correlation between A-type personality and time management disposition in college students(P

The near therapeutic effect of antiglaucomatous operations of various kinds on 266 eyes of 194 patients with various types of glaucoma were evaluated. 82 eyss of 61 patients out of those were followed up from 10 to 193 months(an average of 69 months) and thus the remote therapeutic effect was observed in these cases. In general the near operative results of this series was similar to those of the concurrent reports by other authors, but the remote effect was not satisfactory. Invariably, the therapeutic effect deteriorated as the time went by. The possible factors which led to the deterioration of the therapeutic effect were discussed by the author.Altogether 19 kinds of operative methods were used and four of them, Scheie's operation, subscleral sclerenclesis, interlamellar Scheie's operation and trabe-culectomy were the main methods used. It was found that trabeculectomy resulted in high percentage of success in controlling the intraocular pressure and brought about rather few complications. It was suggested that trabeculectomy be the operation of choice for the treatment, of glaucoma.

Objective To research into the prevention and care of the early stage serious complication caused by hypertensive cerebral hemorrhage,aiming at reducing the death rate and disability rate caused by the illness,and raising the survivors living quality.MethodsBy analysing the serious complication of 90 hyertensive cerebral hemorrhage patients confirmed by CT and the information of prevention and care.Results85 patients had high pressure in the cranial cavity;8 patients had brain hernia;18 patients had heart failure;2 patients had myocardial infarction;8 patients had brain and heart syndrome;3 patients had lung oedema;14 patients had lungs infected;22 patients,kidneys didn,t funtion fully.20 patients bleed in the alimentary canal;38 patients had high blood sugar.51 patients survived,and 39 patients died.The death rate caused by the illness was 43.3%.ConclusionThe incidence of the hypertensive cerebral hemorrhage is high.Has much complication the death rate and disability rate caused by the illness are high.So we should pay attention to the prevention and care of early stage serious the complication of hypertensive cerebral hemorrhage,Control the blood pressure effectively to reduce the serious complication,Death rate and disability rate and improve the prognoses.

Objective To evaluate the clinical effect of preservation of parotid masseter fascia and sternocleidomastoid muscle flap in preventing facial concave deformity and Frey’ s syndrome. Methods 110 patients with parotid gland benign tumor were selected and ran-domly divided into treatment group(56 cases) and control group(54 cases). The treatment group was filled with sternocleidomastoid muscle flap at once and remained parotid masseter fascia in operation. The control group got parotidectomy only. All the cases were followed-up. Re-sults All the cases were successful during a follow-up period of 3~24 months. The treatment group was better than the control group at pre-venting facial concave deformity and Frey’s syndrome (P<0. 01). Conclusion Preservation of parotid masseter fascia and sternocleido-mastoid muscle flap can be the priority selection in improving facial concave deformity and preventing Frey’ s syndrome.

Objective Look into the therapy of Chinese traditional medicine for agedness osteoarthritis and osteoporosis. Methods 56 osteoporosis suffers take the Chinese traditional medicine orally three months. Look into the suffers symptom, bone density and biochemical markers. Results For three months treatment, the suffers symptom is catabatic. The serum calcium, serum phosphorus and bone density are higher than before, t-teat, P＜0.05.The serum bone glaprotein(BGP), bone specificalkaline phosphatase(BALP) and 24 hours urine calcium are lower, ttest, P＜0.01. Conelnsion The therapy of Chinese traditional medicine for agedness osteoarthritis and osteoporosis is prominence and safe.

The technique of lentivirus-based RNAi ( RNA interference) is a combination of the effective infec-tion and integrating characteristics of lentivirus vector and the specificity of RNAi to silence a homologous gene expression. It caused the post-transcriptional gene silencing ( PTGS) by a specific target sequence of mRNA degradation.As a kind of commonly used target cells in gene therapy, T lymphocytes play an important role in graft-versus-host disease ( GVHD) and other diseases.It is of great significance for increasing the infection efficiency of the target gene to T lymphocytes on this kind of disease for gene therapy.In this paper, we summarize the application of lentivirus-based RNAi in T lymphocytes.