Objective:To investigate the mediating effect of family resilience on the relationship between psychological resilience and demoralization in leukemia patients undergoing chemotherapy.Methods:A total of 240 leukemia patients hospitalized for chemotherapy in the Department of Hematology, the First Affiliated Hospital of Zhengzhou University, from January to December 2024 were selected by convenience sampling. The Basic Information Questionnaire, Family Hardiness Index (FHI), Connor-Davidson Resilience Scale (CD-RISC), and the Chinese version of the Demoralization Scale Ⅱ (DS-Ⅱ) were administered. Pearson correlation analysis was used to examine the associations among family resilience, psychological resilience, and demoralization. A structural equation model was constructed with AMOS 21.0 to verify the mediating effect. A total of 240 questionnaires were distributed, of which 232 were valid, yielding a valid response rate of 96.67% (232/240) .Results:The mean scores of the 232 patients were as follows: FHI (51.41±8.27), CD-RISC (51.84±7.96), and DS-Ⅱ (21.03±4.19). FHI was positively correlated with CD-RISC ( P<0.05), while DS-Ⅱ was negatively correlated with both FHI and CD-RISC ( P<0.05). Psychological resilience had a direct negative effect on demoralization ( P<0.01), and family resilience also had a direct negative effect on demoralization ( P<0.01). Family resilience partially mediated the relationship between psychological resilience and demoralization ( P<0.01), accounting for 59.96% (-0.289/-0.482) of the total effect. Conclusions:Psychological resilience and family resilience in leukemia patients undergoing chemotherapy were both at moderate levels, while demoralization was relatively high. Family resilience partially mediated the relationship between psychological resilience and demoralization.

Objective:To investigate the mediating effect of family resilience on the relationship between psychological resilience and demoralization in leukemia patients undergoing chemotherapy.Methods:A total of 240 leukemia patients hospitalized for chemotherapy in the Department of Hematology, the First Affiliated Hospital of Zhengzhou University, from January to December 2024 were selected by convenience sampling. The Basic Information Questionnaire, Family Hardiness Index (FHI), Connor-Davidson Resilience Scale (CD-RISC), and the Chinese version of the Demoralization Scale Ⅱ (DS-Ⅱ) were administered. Pearson correlation analysis was used to examine the associations among family resilience, psychological resilience, and demoralization. A structural equation model was constructed with AMOS 21.0 to verify the mediating effect. A total of 240 questionnaires were distributed, of which 232 were valid, yielding a valid response rate of 96.67% (232/240) .Results:The mean scores of the 232 patients were as follows: FHI (51.41±8.27), CD-RISC (51.84±7.96), and DS-Ⅱ (21.03±4.19). FHI was positively correlated with CD-RISC ( P<0.05), while DS-Ⅱ was negatively correlated with both FHI and CD-RISC ( P<0.05). Psychological resilience had a direct negative effect on demoralization ( P<0.01), and family resilience also had a direct negative effect on demoralization ( P<0.01). Family resilience partially mediated the relationship between psychological resilience and demoralization ( P<0.01), accounting for 59.96% (-0.289/-0.482) of the total effect. Conclusions:Psychological resilience and family resilience in leukemia patients undergoing chemotherapy were both at moderate levels, while demoralization was relatively high. Family resilience partially mediated the relationship between psychological resilience and demoralization.

Diabetic foot is one of the most common and serious chronic complications in diabetic patients.With the advancement of digital healthcare,digital therapy has been gradually implemented and promoted among diabetic foot patients as an emerging tool with the advantages of safety,efficiency,and intelligence that can make up for the shortcomings of traditional diabetic foot risk assessment,health education,and self-management.This study provides an overview of digital therapeutics,summarizes its application in patients with diabetic foot,and proposes relevant recommendations,aiming to provide a reference for improving the quality of life and satisfaction of patients with diabetic foot and reducing the recurrence of diabetic foot.

Diabetic foot is one of the most common and serious chronic complications in diabetic patients.With the advancement of digital healthcare,digital therapy has been gradually implemented and promoted among diabetic foot patients as an emerging tool with the advantages of safety,efficiency,and intelligence that can make up for the shortcomings of traditional diabetic foot risk assessment,health education,and self-management.This study provides an overview of digital therapeutics,summarizes its application in patients with diabetic foot,and proposes relevant recommendations,aiming to provide a reference for improving the quality of life and satisfaction of patients with diabetic foot and reducing the recurrence of diabetic foot.

Objective:To explore the risk factors for peripherally inserted central catheter (PICC) related bloodstream infections in elderly acute leukemia patients during chemotherapy, and construct and validate relevant predictive models.Methods:This study selected 291 patients from the First Affiliated Hospital of Zhengzhou University from January 2019 to December 2020 as the modeling group, and 277 patients from January 2021 to December 2022 as the validation group. Multivariate Logistic regression was used to determine the risk factors for PICC related bloodstream infections during chemotherapy in elderly acute leukemia patients, and a prediction model was constructed and validated based on the analysis results.Results:The incidence of PICC related bloodstream infections in the modeling group was 8.2% (24/291). Multivariate Logistic regression analysis showed that chemotherapy frequency, single catheterization puncture frequency, whether catheterization maintenance frequency was standardized, and catheterization retention time were risk factors for PICC related bloodstream infections in elderly acute leukemia patients during chemotherapy. Based on this result, a prediction model was constructed, and the area under the receiver operating characteristic curve ( AUC) of the modeling group's prediction model was 0.798 [95% CI (0.734, 0.869) ], while the AUC of the validation group's prediction model was 0.745 [95% CI (0.712, 0.844) ]. The calibration curves of the modeling and validation groups showed that the prediction model had high predictive performance. Conclusions:A prediction model for PICC related bloodstream infections in elderly acute leukemia patients during chemotherapy is constructed based on the results of multiple factor analysis, and the predictive performance of the model is verified. Nursing staff can quantify the risk of PICC related bloodstream infections in patients based on this prediction model and implement targeted nursing measures.

ObjectiveTo compare and observe the effect of Reduning injection （mainly clearing heat）， Shenfu injection （mainly warming Yang） combined with gefitinib on the proliferation， apoptosis， stemness characteristics and metabolism of lung cancer cells. MethodDifferent non-small cell lung cancer （NSCLC） cell lines were selected and intervened with gefitinib （5， 10， 20 μmol·L^-1）， Reduning injection （0.6%， 0.9%）， Shenfu injection （0.6%， 0.9%）， gefitinib combined with Reduning injection， and gefitinib combined with Shenfu injection. Cell proliferation in each group was detected by cell counting kit-8 （CCK-8） assay， and cell apoptosis was detected by flow cytometry. The mRNA and protein expressions of lung cancer stem cell markers sex determining region Y-box 2 （Sox2） and aldehyde dehydrogenase family 1 member A1 （ALDH1A1） were determind by real-time quantitative polymerase chain reaction （Real-time PCR） and Western blot， respectively. The redox ratio of lung cancer cells was observed by femtosecond label-free imaging （FLI） and energy metabolism instrument was used to determine the glycolysis level in cells. ResultCompared with the blank group， Reduning injection reduced the survival rate of lung cancer cells （P<0.05）， increased the apoptosis rate （P<0.05）， down-regulated the mRNA and protein expressions of Sox2 and ALDH1A1 （P<0.05）， and up-regulated the redox ratio of cells （P<0.05）， while Shenfu injection exerted no remarkable effect on the above indexes. In addition， compared with gefitinib alone， Reduning injection combined with gefitinib inhibited the survival rate of lung cancer cells （P<0.05）， promoted the cell apoptosis （P<0.05）， down-regulated the mRNA and protein expressions of Sox2 and ALDH1A1 （P<0.05）， up-regulated the redox ratio of cells （P<0.05）， and lowered the proton efflux rate of glycolysis （P<0.05）， while Shenfu injection combined with gefitinib failed to affect these indexes of lung cancer cells significantly. ConclusionReduning injection may inhibit stemness characteristics of tumor cells by regulating their metabolism to enhance the proliferation-inhibiting and pro-apoptotic effects of gefitinib on lung cancer cells， while Shenfu injection had no significant enhancing effect on gefitinib. This indicates that epidermal growth factor receptor tyrosine kinase inhibitors （EGFR-TKIs） should be used in combination with heat-clearing Chinese medicines.

Health behavior decision-making often involves the balance of gains and losses at different time points,which affects the choice and maintenance of health behaviors.As a cognitive processing method of"pre-experiencing"future events,Episodic Future Thinking(EFT)can promote the formation of health intentions and health behavior change by increasing the value of future health outcomes.This paper reviews the concept,intervention model and action effect of EFT in health behaviors,in order to provide references for nurses to innovate health education and behavior management from the perspective of behavioral economics.

Acceptance of disability(AOD)is a key factor in psychosocial adjustment of disabled groups,and a good level of AOD plays an important role in promoting health outcomes of patients.At present,studies on AOD have been carried out in many disease fields.Therefore,this article focuses on the relevant concepts,evaluation tools,manifestations,influencing factors,intervention strategies and other aspects of AOD in diabetic foot amputation patients,aiming to improve patients'prognosis,quality of life and life satisfaction and other aspects for references and help.

Objective:To systematically review the risk prediction models for hypoglycemia in diabetic patients.Methods:The literatures published up to March 25, 2022 was retrieved from PubMed, Embase, Web of Science, Cochrane Library, CINAHL, MEDLINE, China National Knowledge Infrastructure, Wanfang, VIP and SinoMed. Two researchers independently screened the literatures, extracted information, and applied the PROBAST tool to evaluate the quality of the included models.Results:A total of 11 literatures and 13 models were included. The area under the receiver operating characteristic curve or C statistic of all models was 0.666-0.890, with a high risk of bias and a low risk of applicability, and the most included predictors were chronic kidney disease and age. The main reason for the bias in the model were insufficient number of events in the dependent variable, improper handling of continuous variables, and screening of predictors by single factor analysis. Conclusions:The existing hypoglycemia risk prediction models for diabetic patients are still in the development stage, and medical and nursing staff can choose the existing hypoglycemia models according to the results of this systematic review and clinical practice. In the future, we should improve the existing models based on tools or carry out large-sample, multi-center, prospective cohort studies, and build a high-quality hypoglycemia risk prediction model for diabetic patients that is more suitable for China based on more comprehensive and accurate statistical methods and clinical data.

Objective:To explore the effects of cough remodeling exercise in postoperative tracheal intubation nursing among patients with craniocervical junction malformation.Methods:From January 2015 to December 2016, convenience sampling was used to select 40 craniocervical junction malformation patients admitted to the Department of Neurosurgery of the Chinese People's Liberation Army General Hospital and treated with posterior cervical 1 side mass-cervical 2 pedicle screw reduction and internal fixation, and with tracheal intubation as the control group, using traditional breathing exercise. From January 2017 to December 2019, 40 craniocervical junction malformation patients with posterior cervical 1 side mass-cervical 2 pedicle screw reduction and internal fixation and internal fixation, and with tracheal intubation were selected as the experimental group, implementing cough remodeling exercise on the basis of traditional breathing exercise. The cough strength, white card test and tracheal intubation time, average hospital stay, reintubation rate 24 hours after extubation, tracheotomy rate, lung infection rate and other airway management effect indexes were compared between the two groups of patients.Results:After intervention, the cough strength of experimental group was greater than that of control group, and the difference was statistically significant ( Z=-2.158, P=0.031) . The white card test positive rate of experimental group (82.5%, 33/40) was higher than that of control group (55.0%, 22/40) , and the difference was statistically significant (χ 2=7.040, P=0.008) . The median time of intubation in experimental group was 18.25 h, which was shorter than 43.00 h in control group ( Z= -2.728, P=0.006) ; the average hospital stay of experimental group was shorter than that of control group, and the differences were all statistically significant ( Z=-2.848, P=0.004) . There was no significant difference in the reintubation rate 24 hours after extubation, tracheotomy rate, and lung infection rate of the two groups of patients ( P>0.05) . Conclusions:Cough remodeling exercise can enhance the cough strength of patients with craniocervical junction malformation, shorten the time of tracheal intubation and the average hospital stay, which is worthy of clinical application.