Objective Effect of Zhizhu decoction ( ZD) on mast cells( MC) of colonic mucosa in mice with constipation due to spleen asthenia was observed and the relationship between MC and the immunoreactivity of substance P ( SP) and somatostatin ( SS) was explored to investigate the therapeutic mechanism of ZD.Methods The mice models with constipation due to spleen asthenia were induced by the discordance between starvation and engorgement plus overfatigue. The MC count and SP and SS expression were detected by modified toluidine blue method and LSAB immunohistochemical method respectively, and then analyzed with IMS color image processing system and related software. Results The MC density in the colonic mucosa in the constipated mice was reduced. The MC density was correlated positively with the mean intensity and area of SP immunoreactivity ( r=0.6508, P

Objective To further assess the therapeutic effect and safety of Xiaoke Pill (XP) in treating type 2 diabetes mellitus with qi and yin deficiency. Methods A multicentre randomized controlled trial was adopted. Three hundred and four cases were treated with XP and one hundred and one cases treated with glibenclamide troche served as control. Results In XP treatment group, the remarkably effective rate in relieving symptoms was 45. 07 % and the effective rate was 48. 68 % , the differences being significant as compared with that in the control group ( P

0.05 compared with group B);ZT and Youjiangtang Tablets had similar effect in promoting the synthesis of hepatic glucose and the release of serum insulin(P