Objective:To compare the effects of a single dose of dexrazoxane or cAMP and their combined use on anthracycline cardiotoxicity in the multiple treatment course of patients with hematological malignancies to explore better alternatives for reducing an-thracycline cardiotoxicity. Methods: In the study, 80 patients were randomly divided into 4 groups with 20 cases each. Group A ( cAMP group) received cAMP 20 ml·d-1 for a week before every treatment course. Group B was treated with dexrazoxane and adria-mycin at a dosage ratio of 10∶1 via a fast intravenous drip 30 min before the application of anthracycline chemotherapy, and the 20 ml cAMP was given once a week before the chemotherapy session. Group C only received dexrazoxane. Anthracyclines was administered 30 min before each chemotherapy session. Groups A, B, and C were the experimental groups, and group D was designed as the blank control group. All groups received four complete cycles of chemotherapy. The ECG changes, echocardiography ( left ventricular ejection fraction, LVEF) and B-type brain natriuretic peptide ( BNP) values of all the groups were observed before and after the chemotherapy. Results:As for the ECG changes, group B and C had lower incidence rate of abnormal ECG than group A and D(P<0. 008 3). Sig-nificantly decreased LVEF and increased BNP values were observed in group A, B and C compared with those in the control group ( P<0. 05), and group B showed the most significant effect. Conclusion:All of the studied treatments can effectively reduce anthracy-cline chemotherapy-induced cardiotoxicity in cancer patients, and the combination of cAMP and dexrazoxane exhibits the best effect. Dexrazoxane has better protective effect on myocardial cells than cAMP.

Objective To explore the method and clinical effect of via -nasal ileus tube combined urografin to treat early postoperative inflammatory intestinal obstruction.Methods Retrospective analyzed the data of 27 patients with early postoperative inflammatory intestinal obstruction who treated through via -nasal ileus tube intervention. Results The 27 patients were cured through conservative treatment and the cure rate was 100%.The symptom of 10 cases got complete remission 4 to 7 days after put the ileus tube,17 cases got complete remission 8 to 13 days. The passage of gas by anus recovery time was average (12.3 ±2.6)days,time of therapy was average (16.1 ± 3.7)days.The patients were followed up for 6 months to 1 year,none of the patients relapsed.Conclusion The early postoperative inflammatory intestinal obstruction should be treated through conservative treatment positively,decom-pression by via -nasal ileus tube combined urografin has important role to diagnose and treat the disease,the therapy can enhance the therapeutic effect validly and shorten the treatment cycle,it is safe to use in clinic and the effect is satisfactory.

Objective To study the role of homeobox A2(HOXA2) gene in cell growth,cellcycle and apoptosis of hepatoma cells, and discuss the feasibility that HOXA2 gene would be a potential therapy target of hepatoma. Methods Real-time quantitative polymerase chain reaction and revers transcriptional polymerase chain reaction were performed to examine HOXA2 expression in tumorous and non-tumorous tissue of patients was matched with liver cancer. siRNAs were chemically synthesized to interference HOXA2 in PLC/PRF/5 and MHCC-97L cells. Growth curve and soft-agar colony formation assay were performed to evaluate cell growth, and cell cycle and apop-tosis were analyzed by flow cytometry. Results HOXA2 was upregulated in HCC samples compared with matched non-tumor tissues(P<0.05). Two siRNAs against HOXA2 gene were designed and synthesized to specially knock-down HOXA2 in PLC/PRF/5 and MHCC-97L cells. HOXA2 knockdown inhibited cellular growth and soft-agar colony formation in PLC/PRF/5 and MHCC-97L cells. And Fowcytometry analysis revealed that HOXA2 knock-down by RNA interference could result in G1 arrest and S decrease and promoted cellular apoptosis. ConclusionHOXA2 gene has an important role in cell growth of hepatoma cells.

Objective To study the relationship between MRI and histopathological findings of cerebral schistosomiasis,and the value of MRI on this disease. Methods 18 patients with cerebral schistosomiasis proved by pathological examination and laboratory test were enrolled in the study. Plain and Gd DTPA enhanced MRI were performed in all patients with GE 1.5 T MRI scanner. Results The lesions were located in infratentorial region in 7 cases and in supratentorial region in 11. There were three types of pathological pattern in the disease including focal encephalitis and meningiomas (5), granuloma (12), and encephalatrophy (1). Most of the lesions were iso or hypointensity on T 1WI, hyperintensity on T 2WI, with nodules, spot or ring like enhancement, and periphery edema. Conclusion MRI manifestations of cerebral schistosomiasis have specific features,which is a very important tool in early diagnosis and follows up for this disease.

Objective To investigate the printing technique of spiral CT three-dimensional (3D) colour image. Methods The 3D colour images of 136 patients were printed, with the equipment of Marconi spiral CT, personnel computer, colour ink printer, and network switchboard. Results All printed images were satisfied by this method. Conclusion This technique is economic, simple, and useful, and can meet the need for clinical diagnosis and operation.

Objective To observe the curative effect of Qingkailing Injection in treating diabetic foot with ischemic gangrene in early stage and investigate it′s therapeutic mechanism.Methods 40 patients were divided into Qingkailing treatment group (treatment group) and Xuesetong treatment group (controlled group),4 weeks in a treatment course.The foot skin color,skin temperature,degree of tumefaction,rage of gangrene,ability of walking,degree of pain were observed and C-reactive protein (CRP),fibrinogen (Fib) in plasma were detected before and after the treatment respectively.Results After 4 weeks treatment by Qingkailing Injection,the various standards mentioned above in treatment group were improved obviously,Compared with treatment group (except Fib),There was remarkable significance by statistics (P

Objective:To validate the Chinese Version of Depletion Sensitivity Scale (DSS) and test its validity and reliability.Methods:A sample of 499 postgraduates coming from a university in Beijing was investigated with preliminary questionnaire,249 of them were assessed for exploratory factor analysis(EFA) and 250 of them were assessed for confirmatory factor analysis (CFA) and testing of validity and reliability.The criterion validity was tested with the Self-Regulatory Fatigue Scale (SRF-S),Dual-Mode of Self-Control Scale (DMSC-S) and Adolescent Self-rating Life Events Check-list (ASLEC).Totally 280 students were retested for test-retest reliability with 2 week interval.Results:DSS was composed of 8 items in two factors,which were cognitive factor and behavioral factor.The two factors explained 60.7％ of the variances.The confirmatory factor analysis identified a two factor model (x2/df=4.18,RMSEA =0.09,NFI =0.95,NNFI =0.94,CFI =0.96,IFI =0.96,GFI =0.96,SRMR =0.05).The scores of depletion sensitivity were positively correlated with the scores of cognitive fatigue,behavioral fatigue,emotional fatigue poor control,punished,loss,relationship pressure and adaption problem (r =0.13-0.55,Ps ＜0.001).The Cronbach α coefficients were 0.80 for the total questionnaire and 0.79 and 0.73 for the two factors.The test-retest reliability were 0.52 for the total questionnaire and 0.46 and 0.58 for the two factors.Conclusion:It suggests that the Chinese version of Depletion Sensitivity Scale (DSS) is reliable and valid enough to be applicable to measure the depletion sensitivity of Chinese graduate students.

Objective To develop the ego depletion aftereffects scale (EDA-S) and test its validity and reliability.Methods Based on literature analysis and the open questionnaire survey this study compiled the preliminary questionnaire.A sample of 801 subjects coming from a university in Beijing was investigated with preliminary questionnaire and 406 students were retested for test-retest reliability with 2 week interval.Results The EDA-S was composed of 38 items in nine factors,which were emotional regulation difficulty,social withdrawal,low efficacy,working memory impairment,low processing fluency,work burnout,fatigue,somatic distress and low adherence.The eleven factors explained 72.09％ of the variances.Furthermore,the result of CFA indicated that the model fitted the data with well construct validity(x2 =1744.62,df=629,x2/df =2.77,RMSEA =0.06,NFI =0.98,NNFI =0.98,CFI =0.98,IFI =0.98,GFI =0.85,SRMR =0.05) and its factors scores were positively correlated with the SFR-S scores(r=0.31-0.59,P＜0.001).The Cronbach α coefficients were 0.95 for the total questionnaire and 0.73-0.91 for the eleven factors.The test-retest reliabilities were 0.60 for the total questionnaire and 0.26-0.57 for the nine factors.Conclusion It suggests that the EDA-S is reliable and valid enough to be applicable to measure the depletion degree of adolescents.

To investigate the value of the guidance of three dimensional (3-D) reconstruction of multi-slice spiral CT (MSCT) for the placement of pedicle screws, the 3-D anatomical data of the thoracic pedicles were measured by MSCT in two embalmed human cadaveric thoracic pedicles spines (T1-T10) to guide the insertion of pedicle screws. After pulling the screws out, the pathways were filled with contrast media. The PW, PH, TSA and SSA of developed pathways were measured on the CT images and they were also measured on the real objects by caliper and goniometer. Analysis of variance demonstrated that the difference between the CT scans and real objects had no statistical significance (P > 0.05). Moreover, the difference between pedicle axis and developed pathway also had no statistical significance (P > 0.05). The data obtained from 3-D reconstruction of MSCT demonstrated that individualized standards, are not only accurate but also helpful for the successful placement of pedicle screws.

In the process of the introduction of classical problem based learning,the combination of PBL teaching method and current teaching method was found to be abstract and difficult to operate. PBL gradual teaching was brought forward through qestionnaires and analysis. Improved PBL teaching is more suitable for clinical teaching of hepatobiliary surgery in China and helping the interns to get good learning habits. Thus ,it is an effective PBL teahcing method of hepatobiliary surgery.