OBJECTIVE:To prepare diclofenac sodium controlled release tablet,and to evaluate the mechanism of drug release.METHODS:Stearic acid and ethyl cellulose were used as blocking agents and sodium carboxylmethyl starch was used as disintegrating agent.Tablets were made after drying the granules prepared.The dissolution rates were acquired according to Chinese Pharmacopoeia(1995).RESULTS:Drug release from the tablets prepared was of zero-order release before 90% of drug released.No significant influences were observed from the dissolution rates of the different pressure of tablet(5～10kg),amount of drugs contained in the tablet(35%～60%)and different geometry of the tablets,respectively.The remarkable difference waw observed between the disintegrating and blocking agents contained in the tablets.CONCLUSION:The time of 50% of durg released could be changed as the amount of disintegrating or blocking agents were changed.

Objective To investigate the efficacy of dexmedetomidine in reduce of hyperalgesia in patien with remifentanil anesthesia.Methods 84 patients scheduled for laparoscopic hysterectomy from December 2014 to April 2016 were selected and randomly divided into two groups: the observation group and the control group,42 cases in each group,two groups were intravenous infusion of remifentanil,propofol and inhaled sevoflurane to maintain anesthesia.In the observation group,0.6μg/kg of dexmedetomidine was given 40minutes before the end of the operation(adding to 100mL 0.9％sodium chloride solution,infusion within 10minutes),the control group was given the same volume of 0.9％sodium chloride solution.The visual analogue scale(VAS)and the bruggrmann comfort scale(BCS)were used to evaluate the postoperative pain and comfort of the two groups of patients at different time points,and compare the incidence of adverse events between the two groups.Results The VAS scores of the two groups were significantly different at 1h(T1),4h(T2)and 24h(T3),and the VAS score of the observation group was significant better than that of the control group,the difference was statistically significant(P<0.05),the BCS scores of two group were compared at T1 and T2,the difference was statistically significant(P<0.05),but there was no significant difference between the two groups at T3.The incidence of adverse reactions in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Dexmedetomidine can relieve and prevent the incidence of hyperalgesia and adverse reactions in patients with remifentanil anesthesia,and improve the analgesic effect of postoperative patients.

The recent research progress of photo-catalyzed degradation of organic pollutants by TiO2 is reviewed,the characteristics of hydrothermal method and the prepared processes of TiO2 were discussed,the photo-catalyzed mechanism under UV and visible light and the application of degradation of sewage using TiO2 nanomaterials from five aspects were described in this paper. The main problems existing in the studies of TiO2,the research directions,and the development prospects were also discussed.

Objective To investigate the role of sex chaperone on self-acceptance,anxiety,depression and coping strategy in stable phase extensive burn patients'.Methods According to the different role of accompanies,the extensive burn patients in stable phase were divided into sex chaperone accompany groups(treatment group)and non-sex chaperone accompany group(control group).They were assessed by self-acceptance questionnaire(SAQ),self-rating anxiety scale(SAS),self-rating depression scale(SDS)and medical coping modes questionnaire(MCMQ).The results were statistically analyzed.Results The treatment group patients'results are as follows:SAQ total score was(41.37±6.98),self-acceptance factor score was(20.56±4.87),self-evaluation factor score was(22.35±5.82),MCMQ facing factor score was(21.80±4.07),MCMQ avoiding factor score was(22.35±5.82).The results of treatment group patients were significantly higher than those in control group,it had significant differences(P<0.05 or P<0.01);while the treatment group patients'scores of SAS,SDS,MCMQ yield factor were significantly lower that those in the contorl group.The self-acceptance factor score appeared to be negative correlation with the SAS score,SDS score and MCMQ yield factor score,while to be positive correlation with MCMQ facing/avoiding factor score.Conclusion Sex chaperone'accompany can eliminate the extensive burn patients'tension and the effect of adverse psychological factors,and meet family love needs of patients,then improve the level of patient self-acceptance,reverse the negative emotion of patients,and guide patients in a positive way to face the disease.

Objective To develop the neonatal hearing screening,investigate the incidence and relevant high-risk factors of congenital hearing loss,and explore feasible methods of early screening,diagnosis,following-up and intervention.Methods DPOAE was used for the newborns.The children who failed the tests or had high-risk factors of hearing loss were re-screened using DPOAE and AABR 42 days.ABR was used as the diagnostic test for those who had abnormal results at 3 months,ABR and ASSR were used at 6 months for the second diagnosis.The children with hearing loss were intervened in time,and were arranged for routine following-up and audiological evaluation.Results The normal neonates who failed the first screening was 14.8%,infants with high-risk factors was 21.5%,the large number of normal infants passed re-screening and half of high-risk neonates failed.By analysis of patients who had three-month diagnosis,the incidence of congenital hearing loss was about 2.75‰,and mild-grade,middle-grade,severe,profound was 0.18‰,1.78‰,0.26‰ and 0.53‰ respectively.Conclusion The incidence of congenital hearing loss is the highest in congenital diseases,usual screening is necessary.Questionnaire for high-risk factors of hearing loss must be done;it is very important to follow-up the abnormal infants.

ObjectiveTo explore the feasibility of non-nasal packing after correction of nasal septum. Methods53 cases of simple deviation of nasal septum were underwent endoscopic correction of nasal septum.The continuous suction in surgical cavity through catheter without nasal packing after surgery was applied to 46 cases with intact double-mucosa or little wound that could be sutured in front of nasal septum. ResultsOf the 46 patients,the volume of the bleeding 3 days after the operation were(8.1 ± 5.6)ml.The degree of the nasal mucosa edema in 33 patients were lightened than others,the space between the inferior nasal concha and the nasal septum were fine as well as the ventilation of the nasal cavity.Among those cases,there were 13 patients with severe nasal mucosa edema(5 cases were allergic rhinitis)which were treated with ephedrine and furaciline solution or glucocorticoid,as the results,the nasal mucosa shrinked,and the patients could respire well.The catheter were extracted 3 days after the operation until the primary healing.All the cases were healing well without the the nasal septum hematoma and other complications which were follow up more than half a year. ConclusionThe method of continuous suction in surgical cavity through catheter without nasal packing was feasible if double nasal septum mucosa was intact after correction of nasal septum.

Objective To evaluate the safety and efficacy of distal protection device(GuardWire PlusTM) during high risk PCI in patients with acute myocardial infarction(AMI).Methods Seventy-two patients with AMI admitted from September 2004 to May 2006 who received PCI were categotized into the GuardWire PlusTM group(GW group,n=38) and the conventional guidewire group(NGW group,n=34) according to the device used.The basic clinical characteristics,angiographic results,degree ST of resolution and changes in serum CK-MB and cTnI levels were compared.LVEF was measured by echocardiography at discharge and again at 3 months after PCI.Results All the distal protection deveices were applied successfully in the GW group.A greater percentage of patients in the GW group had post procedural ST-segment resolution ≥50% compared with the NGW group(68.4% vs 41.2%,P

0.05).In terms fo LVEF,no differences were found between the 2 groups at 1 week after the operation but patients in the TA group showed higher LVEF at 3 months after the operation compared with the NTA group(P

Objective To explore the pathogenic effect of serum platelet derived growth factor(PDGF) in Henoch - Schonlein pur-pura nephritis(HSPN) and the influence of heparin. Methods The levels of serum PDGF were detected before and after heparin therapy by double antibody ELISA in the peripheral blood of patients. All patients were injected with heparin calcium[100 U/(kg?d)] for two to three weeks. Results The levels of serum PDGF(596.23 ? 199.43) ng/L in 30 HSPN cases before heparin therapy were significantly higher than those of the control group(259.76?69.58) ng/L (P

Objective To explore the effect of dexmedetomidine combined with sufentanil on postoperative analgesia , early postoperative cognitive function and serum inflammatory factors in patients with laparoscopic gastrectomy of gastric cancer.Methods 80 cases of laparoscopic resection of gastric cancer were randomly assigned to treatment group and control group.The control group were treated by sufentanil 1.6μg/kg.The treatment group were given sufentanil 1.6μg/kg combined with dexmedetomidine 2 μg/kg.The analgesic effect, early cognitive function and serum levels of inflammatory factors were tested and compared after surgery.Results Compared with the control group, the VAS score in 4 h,8 h,24 h and 48 h after surgery were lower in the treatment group (P<0.05), the POCD(P<0.05), the IL-6,IL-10 and TNF-αlevel were lower in the treatment group(P<0.05). Conclusion Dexmedetomidine combined with sufentanil showes better postoperative analgesic effect and fast recovery of cognitive function, regulate the levels of serum inflammatory cytokines after laparoscopic resection of gastric cancer .