1.Roles of immunopathological technique in diagnosis of renal diseases.
Chinese Journal of Pathology 2006;35(9):513-516
Complement C3
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metabolism
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Fluorescent Antibody Technique
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Glomerulonephritis, IGA
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diagnosis
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metabolism
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Glomerulonephritis, Membranous
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diagnosis
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metabolism
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Humans
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Immunoglobulin G
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metabolism
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Immunohistochemistry
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methods
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Kidney
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chemistry
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pathology
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ultrastructure
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Kidney Diseases
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diagnosis
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metabolism
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Microscopy, Electron
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Nephritis
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diagnosis
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metabolism
3.Primary hypophysitis
Li ZANG ; Yi-Ming MU ;
Chinese Journal of Endocrinology and Metabolism 2001;0(05):-
Primary hypophysitis includes 3 subtypes:lymphocytic,granulomatous and xanthomatous hypophysitis. The primary hypophysitis has a low morbidity and the final diagnosis is mostly determined based on the pathological findings after operation.Now it is considered as an organ specific autoimmune disease.Its clinical manifestations and imaging features are similar to hypophyseal tumor,but the endocrine and pathologic features are different.Glucocortieoid pulse therapy and surgery are the two methods of treatment.
4. Preparation of paclitaxel-loaded mixed micelles and its in situ absorption in rat intestine
Chinese Pharmaceutical Journal 2013;48(13):1076-1082
OBJECTIVE: To study the oral absorption of paclitaxel-loaded mixed micelles made of D-α-tocopherol polyethylene glycol 1000 succinate(TPGS) and sodium cholate(NaC) in rats. METHODS: Paclitaxel-loaded mixed micelles were prepared by film dispersion method. The Zeta potential and diameter distribution of TPGS/NaC mixed micelles were measured using laser size scattering determinator. The morphology of micelles was observed by transmission electron microscope. Dialysis method was used to evaluate the release behavior of drug-loaded micelles in vitro. The absorption kinetics was obtained by in situ perfusion method in rats. RESULTS: Most of the mixed micelles were spherical with an average diameter of 24.2 nm and the Zeta potential was -7.84 mV. Compared to the bulk drug, the apparent absorption rate constant (Ka)of paclitaxel-loaded mixed micelles was increased significantly. CONCLUSION: TPGS/NaC mixed micelles can improve the oral absorption of paclitaxel and increase its oral bioavailability.
5.Emphasis should be placed on the diagnosis and therapy of tumor induced osteomalacia.
Chinese Medical Journal 2011;124(2):163-165
Humans
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Hypophosphatemia
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blood
;
complications
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Neoplasms
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blood
;
complications
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Osteomalacia
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blood
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diagnosis
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drug therapy
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etiology
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surgery
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Phosphates
;
blood
7.Neurodevelopmental outcome at 18 months of late preterm infants
Chinese Journal of Applied Clinical Pediatrics 2015;30(5):379-383
Objective To study the neurodevelopmental outcome prospectively at 18 months of the late preterm infants.Methods Data from 7 584 live born neonates were collected between January and December.2009 in 3 hospitals located in the north of Chengdu City,Sichuan Province were collected,89 late preterm infants were brought into study ; 170 healthy full-term infants were chosen as the controls randomly.Neurodevelopment outcome was assessed by using neonatal behavioral neurological assessment(NBNA) at 40 weeks corrected gestational age,and Bayley scales of infant development was performed to obtain the physical development index (PDI) and mental development index (MDI) at 3,6,9,12 and 18 months corrected age.Neurodevelopmental outcome of late preterm infants was studied compared with that of the term infants.Results Sixty-three neonates born at the late preterm phase and 115 neonates born at the term phase were successfully followed up.The NBNA scores of the late preterm infants at 40 weeks corrected gestationa] age were significantly lower than those of the term infants.The proportion of the late preterm infants whose scores ≥37 was significantly lower than that of the term infants(82.5% vs 94.8%),the proportion of late preterm infants whose scores <35 was significantly higher than that of the term infants(4.8% vs 0),the proportion of the late preterm infants whose scores in 35-36 was significantly higher than that of the term infants (12.7% vs 5.2%,Z =-2.707,P < 0.05) ;At 3,6,9 and 12 months corrected age,the late preterm infants showed a significant lower PDI scores(t =-4.266,-4.594,-5.663,-2.584) and MDI scores (t =-7.121,-7.829,-7.038,-6.002) than those of the term infants(all P <0.05).Compared with the term infants,the late preterm infants still had lower MDI scores than the term infants at 18 months corrected age(t =-4.115,P <0.05),but no difference was observed in PDI scores between late preterm and the term infants (t =-0.957,P > 0.05).Conclusions Neurodevelopment outcome of the late preterm infants is delayed in the first year compared with term infants.At 18 months corrected age the mental development is still delayed compared with the term infants.Measures should be taken properly to improve the neurodevelopment of the late preterm infants in the early childhood.
8.Efficacy of erlotinib on advanced non-small-cell lung cancer
Cancer Research and Clinic 2011;23(8):509-511
Objective To evaluate the efficacy of erlotinib on advanced NSCLC, and observe its adverse events. Methods An open labeled, expanded access program (EAP) was conducted on 19 pathologically confirmed advanced NSCLC patients who had received at least one regimen chemotherapy.Erlotinib (150 mg) was orally administered daily till disease progression or intolerable adverse events developed.The efficacy was evaluated according to RECIST criteria; the adverse events were evaluated according to NCI criteria.Results In 19 patients, the objective response rate was 21.1% (4/19), and the disease control rate was 84.2 % (16/19); the median progression-free survival time was 7.5 months (3-36 months), and the median survival time was 15.9 months (9-39 months).Adverse events were generally mild (grade Ⅰ or Ⅱ ), including skin rash (84.2 %) and diarrhea (57.9 %). One (5.3 %) patient developed grade Ⅲ elevation of serum glutamate pyruvate transaminase.No grade Ⅳ drug-related adverse event occurred.Conclusion Erlotinib is effective and safe for locally advanced or metastatic NSCLC patients who have failed previous chemotherapy.
9.Hypoxia-inducible factor-1α and small ubiquitin-related modifier
International Journal of Pediatrics 2010;37(2):116-118
Hypoxia-inducible factor-1 (HIF-1) is a key transciptional regulator of cellular and systemic oxygen homeostasis,composed of the two subunits,HIF-1α and HIF-1β.HIF-1α is an inducible subunit regulated by hypoxia,which is posttranslationally modified by various ways,including ubiquitination,phosphorylation,hydroxylation,acetylation and glycation,accordingly affecting its protein's stability,nuclear translocation and regulation of its target genes.Small ubiquitin-related modifier (SUMO) is an micromolecule protein participating in posttranslational modifications of proteins dynamicly in eukaryotic organism,which is similar in structure to ubiquitin.SUMOylation and deSUMOylation are involved in multiple regulations of biologic processes,such as signal transduction,transcriptional regulation,cell cycle processes and biological rhythm.SUMOylation is related to HIF-1α stability and transcription activity in hypoxia,providing a newthread to study self-regulation mechanism of HIF-1α for us.
10.Role and mechanism of telomerase reverse transcriptase in ischemic brain damage
International Journal of Cerebrovascular Diseases 2010;18(9):706-710
Objective Telomerase reverse transcriptase (TERT) participates in pathologic processes of many ischemic damages.It also plays an important role in ischemic brain damage.There are a lot of activation mechanisms of TERT after cerebral ischemia.At present,the hypoxia-inducible factor-1 has been more clearly studied.The protective effect of TERT in ischemic brain damage may be associated with anti-apoptosis,promoting cell survival,promoting angiogenesis,and protecting mitochondria.