1.Movement cecum syndrom diagnose and treetment
Chinese Journal of Primary Medicine and Pharmacy 2008;15(9):1484-1485
Objective To evaluate the diagnose and operation about the movement cecum syndrome.Methods To analyse clinical manifestations and what finned by operation of the movement cecum syndrom 16 cases,to summarize the issues of diagnose.To use a new operation method-accending colo,cecum shorten treates the movement cecum syndrome,observing the result of the treatment.Results 1 case was used with appendectomy,2 cases was treated with appendectomy and cecum fixxing,clinical manifestation do not disappear.13 cases was treated with appendectomy and accending colo、cecum,clinical manifestation disappear,the weight added.Result of the treament is good.Conclusion appendectomy colo,cecum shorten is a good methed for treating movement cecum syndrom.
2.Significance of Urinary Leukotriene E_4 Detection in Children with Respiratory Syncytial Virus Bronchiolitis
Journal of Applied Clinical Pediatrics 2003;0(10):-
0.05). Conclusions The LTs synthesis is elevated in RSV bronchiolitis and LTs may participate in the pathogenesis of RSV bronchiolitis. Leukotriene receptor antagonist may play an important role in RSV bronchiolitis. However there still needs further research on the relationship between LTs and eosinophils count in the pathogenesis of RSV bronchiolitis.
3.Role of TROP2 in cancer and as potential therapeutic target.
Chinese Journal of Pathology 2013;42(12):860-863
Animals
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Antigens, Neoplasm
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genetics
;
metabolism
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Biomarkers, Tumor
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genetics
;
metabolism
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Brain Neoplasms
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metabolism
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Cell Adhesion Molecules
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genetics
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metabolism
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Digestive System Neoplasms
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metabolism
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Female
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Genital Neoplasms, Female
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metabolism
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Glioma
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metabolism
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Head and Neck Neoplasms
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metabolism
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Humans
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Immunotherapy
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Male
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Prostatic Neoplasms
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metabolism
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Signal Transduction
4.Practice and study on communication skills training for eye residents
Chinese Journal of Medical Education Research 2003;0(03):-
It is urgent to train the eye residents'communication skills because of the increasing number of medical disputes. Eye residents improved their doctor-patient communication skills by enhancing awareness on the importance of communication,performing education of psychology and communication skills,understanding a variety of medical laws and regulations,improving clinical skills,and training good medical ethics. No medical disputes happened through such training and assessing. Based on the practice of communication training,this paper puts forward some possible solutions.
5.Thyroid nodules:thyroidectomy or observation?
Chinese Journal of Practical Internal Medicine 2001;0(07):-
Thyroid nodules are very common.Its etiological factors include hyperplasia,adenomas,cancer,cysts,and thyroiditis.Most of thyroid nodules are benign.The management of thyroid nodules whether thyroidectomy or observation is according to their nature.So,the key of the therapy is to identify that they are benign or malignant.We should comprehensive evaluate patients' history,physical examination,laboratory examination,and auxiliary examination for judging the nature of thyroid nodules and making decision in the choose of thyroidectomy or observation.
6.Screening and identification of interaction proteins of human TIP60? by yeast two- hybrid system
Journal of Third Military Medical University 2003;0(14):-
Objective To construct a yeast expression vector containing human TIP60? gene (a spliced form of HIV-1 tat interactive protein,HTATIP,60?103) and screen its interaction proteins by yeast two-hybrid. Methods Human TIP60? gene fragment was amplified by RT-PCR and cloned into pGBKT7 vector. Using TIP60? as bait,the proteins interacting with TIP60? were screened from a human liver cDNA library. The positive clones were analyzed by bioinformatic methods. Results Human TIP60? cDNA was successfully amplified and cloned into the pGBKT7 vector and indentified by double enzyme digestion and DNA sequencing. Using yeast two-hybrid,32 clones were screened from a human liver cDNA library,and 9 positive clones including histone deacetylase 7A (HDAC7A),mouse double minute 2 (DMD2),B-cell CLL/lymphoma 3 (BCL3),endothelin receptor type A (EDNRA),androgen receptor (AR),PHD finger protein 17 (PHF17),Ataxia Telangiectasia Mutated (ATM),CAMP responsive element binding protein 1 (CREB1),orphan steroid receptor BD73 were verified after sequencing. Conclusion The screened interaction proteins with TIP60? by yeast two-hybrid may be involved in the roles of transcriptional regulation of TIP60?.
7.Analyses of the Mycorrhizal Research State and Development in China Based on SCI Database
Microbiology 1992;0(03):-
Papers on mycorrhizas were searched from SCI (Science Citation Index) database. In order to understand the research progress of mycorrhizas in China, the paper on mycorrhizas from 1989 to 2007 was analyzed with method of bibliometrics. Mycorrhizal researches showed an increasing tendency during 1989 to 2007, while the increase was obviously accelerated after 2000. Only 5.22% of the articles were published in journals with impact factor above 5, indicates that the academic levels of researches need being enhanced. Currently the research on mycorrhizas was mainly focused on Arbuscular mycorrhiza (AM), especially on effects of mycorrhizal fungi on plant physiology, effects of mycorrhizal fungi on resistance of host plants, Mycorrhizal diversity community and ecological distribution, and phytoremediation with Mycorrhizal plants. The future research should emphasize in phytoremediation with Mycorrhizal plants and identification of fungal species with molecular biological technology.
8.Development of target therapy for advanced gastric cancer
Chinese Journal of Clinical Oncology 2014;(21):1408-1412
The efficacy of conventional chemotherapy for gastric cancer is extremely limited because of its relatively low chemo-sensitivity and obvious heterogeneity. Molecular phenotype-directed target therapy is important for the improvement of the effi-cacy of conventional chemotherapy in treating advanced gastric cancer. Trastuzumab has been confirmed to have a survival benefit when added to chemotherapy for HER-2 positive gastric cancer. Ramucirumab can increase the survival of gastric cancer patients as second line treatment compared with a placebo. The anti-c-MET monoclonal antibody Rilotumumab indicates promising results in phaseⅡtrial. However, most of the targeting drugs in gastric cancer clinical trials have failed. Therefore, further efforts are required to explore critical targeted genes and effective agents.
9.Observation of clinical curative effect of the joint application of Vitapex paste and AH plus to cure the com-bined periodontic-endodontic lesion
Chinese Journal of Primary Medicine and Pharmacy 2015;(6):841-844
Objective To observe the clinical curative effect of the joint application of Vitapex paste and AH plus,which cured the combined periodontic -endodontic lesion .Methods 72 patients of 113 teeth with the com-bined periodontic-endodontic lesion were chosen ,which were randomly divided into the two groups ,with all complete periodontal initial therapy and routine root canal preparation and dressing at the same time .The observation group included 36 cases of 58 teeth,when the first time to see a doctor ,injected Vitapex paste to the periapical tissue and periodontal tissue sparse area for 1 -2weeks.The sceond time,the tap root canal was closely filled withc AH plus paste and gutta-percha.The control group concludes 36 cases of 55 teeth,with the traditional method,the tap root canal was filled with AH plus paste and gutta -percha directly .Then observation of postoperative emergency response within 1 week,of periodontal clinical indicators (including the PD,BOP,PLI) in 1 month,3 months,6 months after periodontal initial therapy ,and of the long-term curative effect after 1 year.Results 1 week after root canal filling , there were 48 cases no reaction , 9 cases mild reaction and 1 case severe reaction in the observation group , while 47cases no reaction ,7 cases mild reaction and 1 case severe reaction in the control group .There was no statistical difference of evaluation of emergency response between the two groups (χ2 =0.002,P>0.05).Compared with the situations before treatment ,PD,BOP and PLI were all reduced significantly in 1,3 and 6 months after periodontal ther-apy (P<0.05).There was no significant differences of PD ,BOP and PLI between the two groups before treatment (t=0.050,0.019,0.004,all P>0.05),while 1 month (t=2.581,5.984,1.870,all P<0.05),3 months (t=4.806,7.640,1.034,all P<0.05) and 6 months (t=4.612,8.043,1.167,all P<0.05) later,there was statistical difference of decreased value between the two groups .The 1 year follow up showed that significant efficiency in the observation group was 46.55%,and total efficiency was 91.38%,while significant efficiency 27.27% and total effi-ciency 70.91%in the control group ,and there were statistical differences of significant efficiency and total efficiency between the two groups (χ2 =16.761,21.061,all P<0.05).Conclusion With the joint application of Vitapex paste and AH plus ,and two method curing the combined periodontic -endodontic lesion ,there was no evident differ-ence compared with the traditional short -term emergency response .By long-term observation ,found that this method could effectively promote the healing of periapical tissue and periodontal tissue ,and that curative effect is remarkable compared with the traditional method .
10.Minimally invasive diagnosis and treatment of digestive diseases with magnetic anchor
Chinese Journal of Digestive Surgery 2011;10(3):173-175
With the development of minimally invasive surgery,great developments have been made in laparoscopie techniques and digestive endoscopy.However,laparoscopy may cause injury by abdominal puncture,and digestive endoscopy is a painful examination for patients and is difficult to localize the tumor.Magnetic anchor makes use of magnetic attraction in positioning,and it improves laparoscopy and endoscopy by external magnetic field or magnetic handle.Nowadays,combined application of magnetic anchor and laparoscope and endoscope in the treatment of digestive diseases has been accepted by many medical centers,and further researches need to be carried out to realize the aim(small trauma,little pain and quick recovery)of minimally invasive surgery.