1.Movement cecum syndrom diagnose and treetment
Chinese Journal of Primary Medicine and Pharmacy 2008;15(9):1484-1485
Objective To evaluate the diagnose and operation about the movement cecum syndrome.Methods To analyse clinical manifestations and what finned by operation of the movement cecum syndrom 16 cases,to summarize the issues of diagnose.To use a new operation method-accending colo,cecum shorten treates the movement cecum syndrome,observing the result of the treatment.Results 1 case was used with appendectomy,2 cases was treated with appendectomy and cecum fixxing,clinical manifestation do not disappear.13 cases was treated with appendectomy and accending colo、cecum,clinical manifestation disappear,the weight added.Result of the treament is good.Conclusion appendectomy colo,cecum shorten is a good methed for treating movement cecum syndrom.
2.Significance of Urinary Leukotriene E_4 Detection in Children with Respiratory Syncytial Virus Bronchiolitis
Journal of Applied Clinical Pediatrics 2003;0(10):-
0.05). Conclusions The LTs synthesis is elevated in RSV bronchiolitis and LTs may participate in the pathogenesis of RSV bronchiolitis. Leukotriene receptor antagonist may play an important role in RSV bronchiolitis. However there still needs further research on the relationship between LTs and eosinophils count in the pathogenesis of RSV bronchiolitis.
3.Role of TROP2 in cancer and as potential therapeutic target.
Chinese Journal of Pathology 2013;42(12):860-863
Animals
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Antigens, Neoplasm
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genetics
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metabolism
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Biomarkers, Tumor
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genetics
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metabolism
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Brain Neoplasms
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metabolism
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Cell Adhesion Molecules
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genetics
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metabolism
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Digestive System Neoplasms
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metabolism
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Female
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Genital Neoplasms, Female
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metabolism
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Glioma
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metabolism
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Head and Neck Neoplasms
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metabolism
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Humans
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Immunotherapy
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Male
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Prostatic Neoplasms
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metabolism
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Signal Transduction
4.Minimally invasive diagnosis and treatment of digestive diseases with magnetic anchor
Chinese Journal of Digestive Surgery 2011;10(3):173-175
With the development of minimally invasive surgery,great developments have been made in laparoscopie techniques and digestive endoscopy.However,laparoscopy may cause injury by abdominal puncture,and digestive endoscopy is a painful examination for patients and is difficult to localize the tumor.Magnetic anchor makes use of magnetic attraction in positioning,and it improves laparoscopy and endoscopy by external magnetic field or magnetic handle.Nowadays,combined application of magnetic anchor and laparoscope and endoscope in the treatment of digestive diseases has been accepted by many medical centers,and further researches need to be carried out to realize the aim(small trauma,little pain and quick recovery)of minimally invasive surgery.
5.Analyses of the Mycorrhizal Research State and Development in China Based on SCI Database
Microbiology 1992;0(03):-
Papers on mycorrhizas were searched from SCI (Science Citation Index) database. In order to understand the research progress of mycorrhizas in China, the paper on mycorrhizas from 1989 to 2007 was analyzed with method of bibliometrics. Mycorrhizal researches showed an increasing tendency during 1989 to 2007, while the increase was obviously accelerated after 2000. Only 5.22% of the articles were published in journals with impact factor above 5, indicates that the academic levels of researches need being enhanced. Currently the research on mycorrhizas was mainly focused on Arbuscular mycorrhiza (AM), especially on effects of mycorrhizal fungi on plant physiology, effects of mycorrhizal fungi on resistance of host plants, Mycorrhizal diversity community and ecological distribution, and phytoremediation with Mycorrhizal plants. The future research should emphasize in phytoremediation with Mycorrhizal plants and identification of fungal species with molecular biological technology.
6.Structural Equation Modeling for Analyzing the Influential Factors of Mental Health in Medical Students
Chinese Journal of Clinical Psychology 1993;0(01):-
Objective: To deeply investigate the influential factors of mental health in medical students by structural equation modeling.Methods: 480 medical students were tested with SCL-90,adolescent self-rating life events check list and simplified coping style questionnaire,then theoretical model were established and confirmed for the relationships of life events,satisfaction degree with their profession,coping styles and mental health.Results: Study stress,human relations,satisfaction degree towards their profession and coping styles closely correlated with mental health status,and the structural equation modeling fitted the data very well,GFI and AGFI were both larger than 0.90.Conclusion: Use of structural equation modeling has more advantages than the traditional statistical methods,but it should combine with professional knowledge when it is used.
7.Thyroid nodules:thyroidectomy or observation?
Chinese Journal of Practical Internal Medicine 2001;0(07):-
Thyroid nodules are very common.Its etiological factors include hyperplasia,adenomas,cancer,cysts,and thyroiditis.Most of thyroid nodules are benign.The management of thyroid nodules whether thyroidectomy or observation is according to their nature.So,the key of the therapy is to identify that they are benign or malignant.We should comprehensive evaluate patients' history,physical examination,laboratory examination,and auxiliary examination for judging the nature of thyroid nodules and making decision in the choose of thyroidectomy or observation.
8.Screening and identification of interaction proteins of human TIP60? by yeast two- hybrid system
Journal of Third Military Medical University 2003;0(14):-
Objective To construct a yeast expression vector containing human TIP60? gene (a spliced form of HIV-1 tat interactive protein,HTATIP,60?103) and screen its interaction proteins by yeast two-hybrid. Methods Human TIP60? gene fragment was amplified by RT-PCR and cloned into pGBKT7 vector. Using TIP60? as bait,the proteins interacting with TIP60? were screened from a human liver cDNA library. The positive clones were analyzed by bioinformatic methods. Results Human TIP60? cDNA was successfully amplified and cloned into the pGBKT7 vector and indentified by double enzyme digestion and DNA sequencing. Using yeast two-hybrid,32 clones were screened from a human liver cDNA library,and 9 positive clones including histone deacetylase 7A (HDAC7A),mouse double minute 2 (DMD2),B-cell CLL/lymphoma 3 (BCL3),endothelin receptor type A (EDNRA),androgen receptor (AR),PHD finger protein 17 (PHF17),Ataxia Telangiectasia Mutated (ATM),CAMP responsive element binding protein 1 (CREB1),orphan steroid receptor BD73 were verified after sequencing. Conclusion The screened interaction proteins with TIP60? by yeast two-hybrid may be involved in the roles of transcriptional regulation of TIP60?.
9.Progress in research of polyamidoamine dendrimers as gene carriers
International Journal of Biomedical Engineering 2008;31(5):308-311
Polyamidoamine (PAMAM) dendrimers is considered a better genetic carrier for its ability to form with DNA a nano-sized polyelectrolyte complex of high stability and dissolubility. The mechanism of PAMAMmediated gene endocytosis has been fairly clear and the researches in vitro have confirmed that PAMAM had high transfection efficiency and low cytotoxicity. The researches in vivo have further confirmed that PAMAM had a potential application foreground in the field of gene therapy including in the prevention and treatment of ewing's sarcoma and pulmonary fibrosis, in heart transplantation, and in the preparation of falciparum malaria vaccine.
10.Expression of ALEX1 in breast cancer and its clinical significance
Chinese Journal of Pathophysiology 2017;33(2):353-357
AIM: To detect the expression of ALEX 1 in the breast cancer tissues in order to verify whether ALEX1 has correlation with clinical pathological features in breast cancer .METHODS:Real-time PCR and immmunohis-tochemistry were applied to detect the expression of ALEX 1 at mRNA and protein levels in the breast tissues .The statistical analysis were performed for determining the correlation with the level of ALEX 1 and the clinical pathological features in breast cancer .RESULTS:The protein levels of ALEX1 in the breast cancer tissues were lower than that in the non-breast cancer tissues (P<0.01).The expression of ALEX1 had correlations with pathological grade , clinical stage, molecular type (P<0.05) but had no correlation with the patients ’ age, tumor size and tumor types in breast cancer .Furthermore, the result of real-time PCR showed that mRNA expression of ALEX 1 was also significantly reduced in the breast cancer tis-sues (P<0.01).CONCLUSION:The expression of ALEX1 in the breast cancer tissues is lower than that in non-breast cancer tissues .The pathological grade and clinical stage in breast cancer are negatively correlated with the expression of ALEX1.