Asparaginase ; adverse effects ; Child ; Child, Preschool ; Desensitization, Immunologic ; Drug Hypersensitivity ; therapy ; Female ; Humans ; Male ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; drug therapy

Objective:To improve diagnosis and therapy of pseudoaneurysm by retrospectively discussing and analyzing of patients with pseudoaneurysm.Methods:The curative effects in 30 patients with pseudoaneurysm from 2003 to 2006 treated in our department were retrospectively addictive drugs and iatrogenic false.Femoral artery were constantly injuryed position.30 clinical cases were treated by surgical operations.The surgical treatment methods included pseudoaneurysm resection and arterial ligation in 9 cases,arterial suture in 3 cases,pseudoaneurysm resection and arterial suture in 15 cases,pseudoaneurysm resection and artificial vascular or autogenous saphenous vein bypass grafting in 3 cases.Conclusion:Pseudoaneurysm could be successfully cured after accurate diagnosis and proper surgical therapy.

BACKGROUND: Previous research reveals that, the morphous, structure, physicochemical property and mechanical characteristics of matrix in buffalo cornu all contribute to the biomaterials in the field of orthopaedics.OBJECTIVE: To investigate the correlation between the duration of matrix in buffalo cornu soaked in 30% hydrogen peroxide and the antigenicity, the biomechanical intensity of matrix in buffalo cornu treated by deproteinization.DESIGN, TIME AND SETTING: Measurement experiments were performed in the Mechanics Laboratory, Kunming University of Science and Technology (Kunming, Yunnan, China) from February to March in 2000.MATERIALS: Buffalo was provided by Luxi Abattoir of Yunnan Province (China), and then processed into test pieces at a nominal thickness.METHODS: The metric test pieces were rinsed with distilled water and soaked by chloroform-methyl alcohol at a ratio of 1:1 for 48 hours, then in 30% hydrogen peroxide for 24 and 48 hours, which served as the experimental group. While those remaining untreated were taken as controls.MAIN OUTCOME MEASURES: The modulus of elasticity and compressive strength were measured by electric measurement method and direct pressurization method, respectively.RESULTS: The modulus of elasticity between the experimental group and the control group had no significant difference (P>0.05). The compressive strength in the control group was significantly higher than that in the experimental group (P<0.01), and there were no significant differences between the experimental group treated for 24 hours and the experimental group treated for 48 hours (P>0.05).CONCLUSION: Subsequent to soaking in 30% hydrogen peroxide for 48 hours, the matrix in buffalo cornu maintains better biomechanicai intensity.

Mutual promotion, mutual assistance and mutual inhibition are commonly for the compatibility of Chinese herbs, but they are also existed among the acupoints. In the paper, the relevant literature on acupoint, compatibility was collected and the mutual promotion, mutual assistance and mutual inhibition relationships of acupoints were described. The laws of the above mentioned combinations, the theoretic evidences and modern researches were summarized briefly. The mutual promotion and mutual assistance refer to the coordination of acupoints, presenting the relationship of the primary and the secondary about the mutual assistance. Hereby, the acupoints could be divided into the simple assistant acupoints and the acupoints from the affected meridians. The mutual inhibition is used to describe the antagonism effect in acupoint combination. There are more researches on the mutual promotion of acupoint combination but less ones on the mutual inhibition and its mechanism is just hypothetic. It is very important to have the deep study on those compatibility relationships for the improvement of acupuncture efficacy and to elaborate the effect mechanism.
Acupuncture Points ; Acupuncture Therapy ; history ; China ; History, Ancient ; Humans ; Medicine in Literature ; Meridians

Objective To investigate the effects of electro-acupuncture (EA) on remyelination after sciatic nerve was transected in rats, so as to explore the possible mechanism of EA in treatment of peripheral nerve injury. Methods After transection of rat's sciatic nerve, the nerve regeneration chamber was built,then the rats were given EA stimulation at frequencies of 5 Hz and 100 Hz, respectively, and Solochrome Cyanine staining, HE staining of nerve fibers, immunohistochemical staining and semi-quantitative image analysis technique were employed to observe the remyelination of the nerve fibers and S-100 protein expression of Schwann cells. Results EA could significantly promote remyelination of the nerve fibers, elevate S-100 protein expression of Schwann Cells in repairing process of transected sciatic nerve of rats. The therapeutic effect of 5 Hz EA group was better than that of 100 Hz EA group. Conclusion EA is an effective way for the treatment of peripheral nerve injury. It can promote proliferation of Schwann cells and nerve fiber myelination. The therapeutic effects of EA are frequency-depondent.

Selective serotonin reuptake inhibitors (SSRIs),a new generation of anti-depressant agent,are mainly used to treat emotional disorders in clinical practice now.Recent studies have found that SSRIs can increase neurogenesis after cerebral ischemia,promote neurovascular reconstruction,and are conducive to the recovery of neurological function.Furthermore,SSRIs can improve the tolerance of ischemic tissue,exert anti-inflammation and anti-oxidation properties,reduce the blood-brain-barrier injury,and inhibit excitatory amino acid toxicity in order to exert neuroprotective effect.This article reviews the related research progress in SSRIs and ischemic stroke.

AIM　To build a model of two series of PPARγ agonists thiazolidinedione and aryketo-acid derivatives using 3D-QSAR method, and to reveal the structural features affecting the binding activity to PPARγ, which relates to antihyperglycemic and antihyperlipidemic activity and has a potential application to the treatment of type II diabetes. METHODS and RESULTS　48 agonists with selective activity for PPARγ were analyzed using CoMFA. Based upon the active conformation of rosiglitazone (BRL) extracted from its complex with PPARγ all agonists were aligned. The model from CoMFA showed a high ability to explain and predict the activity of PPARγ agonists with cross-validation correlation coefficient R2=0.656, that of non-cross-validataion R2=0.982, F10，37=201.1, and SE=0.115. CONCLUSION　The CoMFA contour map indicates that the steric fields mainly contribute to the binding effect, and especially a bulky group in the arylketo-acid series favors in the increase of affinity for PPARγ, as compared to the thiazolidinedione.

Objective To study the association among the color Doppler flow pattern, vascular distribution and the lymph nodes metastasis in breast carcinomas. Methods Sixty-eight patients with infiltrating mammary gland duct carcinoma were divided into the no-lymph-nodes-metastasis group (group I , 37 cases) and the lymph-nodes-metastasis group (group Ⅱ , 31 cases), group Ⅱ were subdivided into group Ⅱa (19 cases): lateral lymph nodes positive of pectoralis minor and group Ⅱ b (12 cases): rear of pectoralis minor and subclavian lymph node positive. Blood flow parameters [peak systoltc velocity (PSV),resistent index ( RI)] and vascular Alder grades were observed and measured with color Doppler ultrasound.The results were compared with the incidence of lymph node metastasis. Results PSV and RI were not significantly different between group Ⅰ and group Ⅱ (t = -0.19,-0.63,P＞ 0.05),and also between group Ⅱ a and group Ⅱ b (t =-1.12,-013,P ＞0.05). By using vascular Alder grades,there were no significant differences between group Ⅰ and group Ⅱ (x2= 0.46, P＞ 0.05 ), but the significant differences were observed between group Ⅱ a [10.5%(2/19) ,63.2%( 12/19) ,26.3%(5/19) in Alder Ⅰ , Ⅱ , Ⅲ grade] and group Ⅱ b [8.3%( 1/12), 16.7%(2/12),75.0%(9/12)in Alder Ⅰ , Ⅱ ,Ⅲ grade](x2 = 7.41,P＜0.05). Conclusion The pattern of blood flow has no correlation with lymph nodes metastasis, vascular Alder grades of carcinoma shows some relevance with the lymph nodes metastasis in the patients with infiltrating mammary gland duct carcinoma.

Objective To explore the applied value of MRI in diagnosing pyogenic of infection of gluteus muscles.Methods MRI data in 9 cases with pyogenic infection of gluteus muscles proved by operation or biopsy were retrospectively analysed by comparison with the pathological diagnosis.Results The pyogenic infections localized at unilateral gluteus muscles involving single,two or three gluteus muscles in all cases.On MRI,the infective gluteus muscles were swelling diffusely and the infections developed along the long axis of the muscles and most or all gluteus muscles were involved.4 cases appeared as suppurative myositis and 5 cases developed typical abscess.4 cases were accompanied with subcutaneous edema and the abscess broken into skin in one case.Conclusion The pathological characteristics of the stage and extent of the pyogenic infection in gluteus muscles can be displayed by MR imaging.

Objective To approach the characteristics of low-field MRI in early stage of cerebral hemorrhage.Methods 38 cases with early stage of cerebral hemorrhage (superacute stage in 26 and acute stage in 12) underwent low-field MRI examination.Results The hematomas located in the basal ganglia regions in 23,thalamus in 9 and other intracerebral regions in 6.The hematomas appeared as reniform,suborbicular or irregular shape with different size.The hematomas exhibited homogeneously iso-intensity on T_1WI and iso-,slightly high or high signal intensity on T_2WI and FLAIR,in which 5 hematomas exhibited iso- or slightly high signal intensity on T_2WI,and 4 hematomas exhibited homogeneously or inhomogeneously high signal intensity on DWI.There was brain edema around the hematomas.25 hematomas had occupied effect,and 4 hemotomas broke into ventriculus and 2 hemotomas caused by hemorrhage of broken arteriovenous malformation.Conclusion Low-field MRI is of high sensitivity and specificity in diagnosis of early stage of cerebral hemorrhage.