Objective:To understand the application status of precursor drugs in the outpatients of our hospital. Methods:Totally 12 kinds of precursor drugs were included in the management. The data of prescriptions in HIS were collected from July 1 to September 30 in 2015. The defined daily dose (DDD), frequency of drug use (DDDs), drug utilization index (DUI) and the other parameters were calculated and the influencing factors were analyzed by the Pareto method. Results: Among the twelve precursor drugs, DUI of seven kinds was less than or equal to 1. Paracetamol tablets, pseudoephedrine hydrochloride tablets, dextromethorphan hydrobromide and chlorphenamine maleate tablets, nicergoline tablets and compound dextromethorphan hydrobromide tablets II displayed lower DUI, indicating their clinic application was more reasonable. Conclusion:The data showed that the use of precursor drugs in our hospital is basically reasonable.

Objective:To statistically analyze the prescription writing norms of narcotic drugs for injection in the operation room and inpatient area of our hospital to improve the prescription writing quality and the efficiency of management. Methods:A retrospec-tive research method was adopted, and 17 103 prescriptions for narcotic drugs for injection in the operation room and inpatient area were collected and analyzed from June to August in 2014. Results:The irregular proportion of prescriptions of narcotic drugs for injec-tion was 9. 05%, and the abnormal item was lack of the text. The proportion of prescriptions using residual amount and needing to be marked was 4. 01%. Conclusion: Improving the management and unifying the prescriptions of narcotics, or applying the electronic prescription if allowed will improve the quality of prescriptions of narcotics and achieve the purpose of fine management.

Objective:To investigate the residual narcotics for injection after used in wards in order to provide evidence for the use standardization of narcotics for injection. Methods:A retrospective research method was adopted. Totally 5 288 prescriptions including narcotic drugs for injection in wards were collected and analyzed from June to August in 2014. Results:Only four kinds of narcotics for injection were used in wards, the residual proportion of morphine hydrochloride injection and pethidine hydrochloride injection was 2%, and that of fentanyl citrate injection was 0. 2%. Conclusion:The residue of narcotics for injection in wards is very little, and the specifi-cations of the medication in our hospital meet the demands of clinics. The research is beneficial to improving the management efficiency.

Objective To identify a clinical isolate of Mycobacterium abscessus.Methods A pus sample was collected from a patient with suspected nontuberculous mycobacterial infection who visited the Affiliated Hospital of Weifang Medical University on December 18,2017,and was subjected to bacterial culture,Gram staining and acid-fast staining.Drug sensitivity test was conducted by the proportion method.The genome DNA of the strain was extracted and amplified by PCR with the universal primer of 16S rRNA.The PCR products were sequenced after collection and purification,and were compared with the known sequence of Mycobacterium abscessus in GenBank database.The isolate was identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS).Results The clinical isolate was identified as Mycobacterium abscessus both by MALDI-TOF MS and 16S rRNA gene sequencing.The drug sensitivity test showed that the strain was sensitive to amikacin,moxifloxacin,levofloxacin,but was resistant to streptomycin,isoniazid,rifampicin,ethambutol,ofloxacin,kanamycin,capreomycin,aminosalicylic acid,protionamide and rifabutin.The patient was diagnosed with subcutaneous soft tissue infection in the left knee joint.According to the results of drug sensitivity test,the patient was treated with amikacin and levofloxacin,and her condition was improved after treatment.Conclusion The 16S rRNA gene detection and MALDI-TOF MS both can be applied in the identification of Mycobacterium abscessus.

Objective: The present study investigated the role of a diode laser in the treatment of fistula chronic periapical periodontitis in elderly people. Methods : A total of 114 cases of fistula chronic periapical periodontitis in the elderly were randomly divided into an experimental group and control group. In the experimental group, a diode laser was used to disinfect the root canal and the internal wall of the fistula after root canal preparation, and Vitapex paste was used in both groups for root canal disinfection. The control group was treated with conventional root canal therapy without laser treatment. The fistula healing rate was calculated, and root canal filling was performed in both groups two weeks later if the fistula was healed. A curative effect was observed at 3 months and 12 months. Results : The fistula healing rate was 90.0% in the experimental group and 75.8% in the control group after 2 weeks. There was a significant difference between the two groups at 2 weeks (χ2 = 4.19, P < 0.05) but not at 3 months and 12 months (P > 0.05). Conclusion The use of a diode laser to disinfect the root canal and fistula of teeth in the elderly with fistula periapical periodontitis can significantly shorten the healing time of fistula.

BackgroundAgitated behaviour in male patients with schizophrenia can lead to serious consequences for the individual and the society. Non-invasive drug delivery may help to rapidly control agitation and improve the overall patient satisfaction， but there are limited studies on the efficacy of olanzapine oral soluble film for the treatment of agitated behaviour in patients with schizophrenia. ObjectiveTo compare the efficacy and safety profile of olanzapine oral soluble film versus intramuscular haloperidol against agitated behaviour in male patients with schizophrenia， so as to provide a reference for the treatment of agitated behaviour. MethodsFrom May 2022 to July 2023， a consecutive sample of schizophrenic patients （n=44） with agitated behaviour who met the Diagnostic and Statistical Manual of Mental Disorders， fifth edition （DSM-5） were recruited in the male psychiatric closed ward of the Third People's Hospital of Fuyang. Patients were assigned into two groups using the random number table method， each with 22 cases. Study group was treated with olanzapine oral soluble film 10 mg/d， while control group was given intramuscular haloperidol 8 mg/d. The severity of agitated behaviour was determined using Positive and Negative Syndrome Scale-Excited Component （PANSS-EC） and Agitation Calmness Evaluation Scale （ACES） at the baseline and after 6 h of drug administration. The treatment response rate was calculated based on the reduction of PANSS-EC score， and the drug side effects were assessed using Rating Scale for Extrapyramidal Side Effects （RSESE） and Barnes Akathisia Rating Scale （BARS） after 6 h of drug administration. ResultsAfter 6 h of drug administration， no statistical difference was reported in PANSS-EC score and ACES score between two groups （F=0.039， 0.082， P>0.05）， and the treatment response rate yielded no statistical difference between two groups （χ²=0.419， P=0.517）， while study group reported a lower incidence rate of adverse reactions compared with control group， with statistically significant difference （P=0.031）. BARS scores noted no statistical significant difference between two groups （t=0.587， P=0.561）， whereas study group scored lower on RSES compared to control group， with a statistical difference （t=-7.367， P<0.01）. ConclusionIn the treatment of agitation in male patients with schizophrenia， the efficacy of olanzapine oral soluble film is comparable to that of intramuscular haloperidol， while the safety profile of the former is superior to that of the latter. ［Funded by Scientific Research Project of Fuyang Municipal Health Commission （number， FY2021-147）， Anhui Provincial Medical and Healthcare Key Speciality Construction Project （number， 〔2021〕273）； www.chictr.org.cn number： ChiCTR2200063052］