78 rabbits in this study were divided into two parts and each part had 39 rabbits. In part Ⅰ and Ⅱ the effects of rhubarb injection on the febrile response and the change of cAMP contents in CSF in these rabbits were observed respectively. The results showed that LP+rhubarb group: △T (0.70?0.12); TPI_4 (3.37?0.07) and LP group:△T (1.11?0.11);TRI_4 (5.56?0.10) comparing of two groups, had markable statistical significance (P