1.REVIEW OF STUDIES ON ARABINOFURANOSIDASES
Jianjun PEI ; Yemin XUE ; Weilan SHAO ;
Microbiology 1992;0(04):-
Hemicellulose is a kind of very abundant carbohydrate,which is not y ot exploited Arabinofuranosidase is important enzyme in biodegradation of hemi cellulose Up to now many arabinofuranosidases and genes have been studied in t he world In this paper, we reviewed mainly on the classification, characterizati on, utility and gene expression of arabinofuranosidase
2.Adiponectin attenuates H2 O2-induced SH-SY5 Y cell injury and tau hyper-phosphorylation via activating PP2 A
Zhe SONG ; Chao XUE ; Xiaoman ZHANG ; Yemin ZHANG ; Xiaohua HE ; Jun YIN
Chinese Journal of Pathophysiology 2015;(2):207-212
AIM:To study the effects of adiponectin on H 2 O2-induced cell injury and tau hyperphosphorylation in human neuroblastoma SH-SY5Y cells.METHODS:Cell viability was determined by MTT assay .H2 O2-induced cell in-jury and morphological changes in the SH-SY5Y cells with or without adiponectin treatment were observed .The level of tau phosphorylation as well as the activities of protein phosphatase 2A (PP2A) and of glycogen synthase kinase-3β(GSK-3β) were examined by Western blotting . RESULTS: Adiponectin significantly attenuated H 2 O2-induced cell injury (P<0.01).Adiponectin upregulated the activity of PP2A and decreased phosphorylation levels of tau under the stimula-tion with H2O2(P<0.01).Okadaic acid, a specific inhibitor of PP2A, blocked the protective effects of adiponectin (P<0.01).Adiponectin increased the phosphorylation level of GSK-3βat Ser9 site under H2O2stimulation (P<0.01).CON-CLUSION:Adiponectin protects SH-SY5Y cells against H2O2-induced cell injury and decreases tau hyperphosphorylation by activating PP2A and inactivating GSK-3β.