Objective To compare and analyze the Brucea javanica oil emulsion,hydroxy camptothecin bladder perfusion of recurrence after operation of superficial bladder cancer.Methods 80 cases with superficial blad-der cancer were randomly divided into group A and group B (n=40 ).Group A received intravesical instillation of Brucea javanica oil emulsion,group B received intravesical instillation of hydroxycamptothecin.The serum tumor marker levels were compared between two groups,and the recurrence rate and adverse reactions in the two groups were observed.Results At 1 day before operation,postoperative 7d,the serum Dickkopf-1 (DKK-1 ),Dickkopf-2 (DKK-2),Dickkopf-3(DKK-3),Dickkopf-4(DKK-4),vascular endothelial growth factor A(VEGFA), vascular endothelial growth factor B(VEGFB),vascular endothelial growth factor C(VEGFC)of the two groups had no statistically significant differences (P>0.05).Postoperative 6 months,the serum levels of DKK-1,DKK-2, DKK-3,DKK-4,VEGFA,VEGFB,VEGFC in group A were (20.62 ±2.84)g/L,(29.15 ±6.32)g/L,(18.66 ± 4.53)g/L,(32.34 ±6.42)g/L,(80.72 ±9.16)g/L,(60.43 ±16.73)g/L,(70.31 ±8.41)g/L,respectively, which were lower than those of group B [(27.42 ±3.76)g/L,(38.16 ±4.34)g/L,(30.37 ±5.35)g/L,(47.26 ± 7.72)g/L,(146.31 ±12.44)g/L,(83.14.14.07)g/L,(91.58 ±7.82)g/L,respectively,t=-2.92,-2.58,-2.82,-2.41,-2.80,-2.75,-2.70,all P<0.01].The recurrence rate of group A was 7.5%(3/40),which was significantly lower than 15.0%(6/40)of group B(6/40)(χ2 =6.11,P <0.05).The incidence rate of adverse reac-tions of group A was 12.5%,which was significantly lower than 27.5% of the control group(χ2 =5.46,P<0.05). Conclusion Compared with hydroxyl camptothecine vesical perfusion,the effect of intravesical instillation of Brucea javanica oil emulsion in preventing the postoperative recurrence of superficial bladder cancer is more significant,can effectively reduce the levels of serum tumor marker,with less adverse reactions,it is worth application and promotion.

Objective To determine the recipe of invigorating kidney for regulating menstruation com?bined with curved repairing in the treatment of polycystic ovary syndrome( PCOS) ovulation disorder related out?come measures,and to evaluate the clinical curative effect of the therapy. Methods Sixty?eight cases of PCOS ovulation disorder patients were randomly selected and randomly divided into the pure western medicine treat?ment control group and integrated traditional Chinese and Western medicine treatment of the observation group, each group had 34 cases. The control group patients were given oral progestin capsule with 0. 2 g/time,1 time/d, and continuous oral administration for 10 days,Letrozol tablets began to take on the fifth day of menses,2. 5 mg/time,1 time/d,and continuous oral administration for 5 days. The observation group on the basis of the control group treatment,invigorating kidney for regulating menstruation recipe treatment began to take on the fifth day of menses,daily 1 agent,water frying to 400 ml,2 times a day,and continuous oral administration for 15 days as a cycle of medication,2 groups of patients were treated for 3 courses of treatment. Measurement of two groups be?fore and after treatment in patients with serum luteinizing hormone(LH),follicle stimulation hormone(FSH), LH/FSH ratio,serum testosterone( T) ,estuarial( E2) ,and fasting,meal after 1 and 2 h insulin( INS) levels,and then compared the two groups of patients with follicular maturation rate,the ovulation rate,pregnancy rate and a?bortion rate. Results The LH(t=9. 763,P=0. 003),serum T(t=1. 906,P=0. 023),LH/FSH(t=3. 098,P=0. 026) and fasting insulin(t=5. 973,P=0. 004),postprandial 1H insulin(t=17. 009,P=0. 000),2 h pan?creatic island prime( t=20. 313,P=0. 000) levels of observation group were significantly lower than that of the control group after administration of treatment,while E2(t=121. 1,P=0. 924),FSH(t=0. 879,928) levels of two groups before and after treatment did not change significantly, there was no statistical significance differ?ence. Mature follicles rate,ovulation rate and pregnancy rate of observation group were obviously higher than that of the control group(75. 1% vs. 46. 9%,89. 4% vs. 68. 5%,86. 6% vs. 42. 3%,χ2=10. 635,8. 428,9. 372;P=0. 000),while the abortion rate was significantly lower than that of the control group(10. 2% vs. 20. 3%,χ2=11. 744,P=0. 002). Conclusion The recipe of invigorating kidney for regulating menstruation combined with leptosome in the treatment of polycystic ovary syndrome ovulation has definite curative effect,it is worthy of pro?motion.

Experiments on humans and rats were conducted to observe the adaptation of exercise-induced muscle injury to repeated exercise. The results indicated that the ratings of perceived exertion (RPE) in the male students of the Physical Education Department reached to the peak immediately after one bout of exercise, while the muscle soreness, the contents of serum creatine kinase (CK) and myoglobin (Mb) reached their peak on the third day post exercise, but later they gradually recovered until to their pre-exercise level on the seventh day post exercise. More obvious changes took place in the RPE, muscle soreness, serum CK and Mb one week after exercise compared with those after one bout of exercise, however, recovery began on the fourth day post exercise in the above indices. Moreover, the results in rats showed the most serious damage in the ultrastructure of skeletal muscle 24 to 48hs after one bout of exercise, but the damage became less serious on the seventh day after exercise. Besides, after 7-day repeated exercise of the same intensity, no further damage was seen in the ultrastructure of skeletal muscle, and the damage recovered on the seventh day after exercise. The results of this study suggested that an adaptation response had taken place after repeated bouts of exercise.

Objective To study the standardization of analgesia in total knee replacement (TKA),and to assess its efficacy and safety of perioperative period application.Methods 64 cases of total knee arthroplasty cases were selected,with 30 cases of male,and 34 cases of female(Aged 61 -78),included 28 cases on the left side,and 36 cases on the right side.According to the random of prefabricated CARDS (1 :1 parallel design of experiment) patients were divided into observation group and control group,with 32 cases in each group(17 cases were women, 15 cases were male,).The observation group were treated with standardized analgesia,the control group were treated with traditional postoperative controlled intravenous analgesia (PCIA)pump.48 h after surgery,the different time points after waking up general anesthesia visual analogue scale (VAS),giving pain sleepers auxiliary analgesic drug application were recorded.VAS score and analgesic drug usage and complications (nausea,vomiting,respiratory depression,motor nerve paralysis,etc.)incidence index etc.of the two groups of patients were compared.Results 64 patients were included in the study,the differences of the two groups of patients in age [observation group:(68.22 ± 0.18),the control group:(69.69 ±0.17),t =5.767,P =0.8237)],gender(15 cases were men,17 cases were women),body mass index [BMI,observation group:(23.38 ±0.19),the control group:(23.94 ±0.14),t =2.339, P =0.082)],the American society of anesthesiologists (ASA)classification (both for 10 cases of ASA grade I,ASA grade II 22 cases),had no statistical significance (P >0.05).And different time points after surgery anesthesia to VAS score had significant difference:[(control group:6 h resting 2.888 ±0.049 /ankle pumps 2.941 ±0.028,12h resting 4.731 ±0.028 /ankle pump 5.747 ±0.033,24h resting 6.859 ±0.033 /ankle pump 7.175 ±0.03,48h resting 4.14 ±0.03 /ankle pumps 5.209 ±0.025.observation group:6h resting 1.316 ±0.024/ankle pumps 1.884 ± 0.023,12h resting 2.05 ±0.02 /ankle pump 3.060 ±0.02,24h resting 2.35 ±0.02 /ankle pump 3.934 ±0.018, 48h resting 2.119 ±0.015 /ankle pumps 2.317 ±0.017.t value resting/ankle pump:6h,17.80 /28.75.12h,76.67 /69. 14.24h,116.9 /91.95.48h,61.11 /95.51.P <0.01)].Analgesic drug usage (control:55.97 ±0.25,the observation group:19.53 ±0.19,t =113.1,P <0.01),the incidence of complications (control:0.45 ±0.00,observation group:0.06 ±0.00;t =169,P <0.01 ),and other aspects of the differences were statistically significant (P <0.05 ). Conclusion Standardized analgesia on the perioperative analgesic effects of total knee arthroplasty is better than PCIA.It can significantly reduce the extra analgesic drug usage,decrease the incidence of complications,and has the characteristics of safe and efficient.

It was well known that the damage of skeletal muscle occurred and exercise performance declined after one prolonged eccentric exercise.But there were few studies on the adaptation to the continuous eccentric exercise in skeletal muscle.The purpose of this study was to investigate the effects of downhill running once(group B) and for one week(group C ) on α-actin gene expression of rat gastrocnemius muscle.Serum CK and LDH were determined, too.The results showed that the training had obvious effects on α-actin gene expression of rat gastrocnemius muscle in group B and C.In group B, serum CK and LDH recovered obviously 7 days after training, but not to the normal value.In group C, it recovered to the normal.These results suggest that the recovery of the damage after first training had been accelerated by the continuous eccentric exercise, the subjects gradually adapted to exercise.

Cranial irradiation is routinely used for the treatment of almost all brain tumors,but it may cause disastrous injury in brain,especially in the hippocampus that has cognitional and emotional regulation functions.Several studies have investigated the mechanisms of radiation-induced hippocampal dysfunctions such as hippocampal neurogenesis,neurotrophin and neuroinflammation,and provided effective prevention strategies such as exercise,environmental enrichment,anti-inflammatory and intrahippocampal transplantation of neural stem cells.This review discussed the curent progresses and challenges of hippocampal dysfunction induced by cranial irradiation and provided new insights for preclinical and clinical researches.

New method of prostate cancer has grown more precise with the development of medical imaging.Multi-parametric MRI targeted biopsy and fusion biopsy reduce the cores,at the same time they have similar positive rates compared to systematic biopsy.The most used biopsy methods are still transrectal guided transrectal biopsy and transperineal biopsy in China.If we can predict biopsy result before the operation by physical and laboratory examination,it will help improve the detection rate and avoid repeating biopsies.And it has been indicated that age,tPSA,PSAD,fPSA/tPSA,PV,DRE,PHI and PCA3 are the predicting factors.Chinese Prostate Cancer Consortium Risk Calculator is fit for Chinses people.

Androgen receptors appear to play a significant role in the hepatocarcinogenesis.Androgen receptors are found to be expressed in liver tumor,and the overexpression of androgen receptor is associated with poor prognosis.Recent researches have indicated that androgen receptors regulate various cellular events in liver carcinogenesis through various ways,and androgen receptor could be a potential cancer therapeutic target in hepatocellular carcinoma.

Objective To construct an effective network machine room (NMR) in hospital. Methods According to Computer Room Design Standard (GB50174-93), the NMR of XiJing hospital was designed and configured in reason with special equipment in such aspects as fitment, power distribution, air conditioning, monitoring, lightning proof, etc. Results The improvement of network machine running condition provided better support to network equipment and ensured the nicety and reliability of the database of XiJing hospital. Conclusion The project attains the anticipated effect. Network equipment running in well environment is the precondition of stabilization of the whole network system in hospital.

AIM: The multiple effective components in Yiqing Capsule(Radix et Rhizoma Rhei,Rhizoma Coptidis,Radix Scutellariae) were analyzed by RP-HPLC. METHODS: A column of Kromasil C_(18)(250 mm?4.6 mm,5 ?m)was used.The mobile phase was composed of A 0.5% triethylamine(pH3.0,containing 5 mmol/L SDS),B methanol and acetonitrile(50∶50) with gradient elution.The flow rate was 1.0 mL/min with the detection wavelength at 254 nm. RESULTS: In the linear range the correlation coefficients ranged from 0.999 4 to(0.999 9).The average recoveries were 95.2%-102.2% with corresponding RSD of 0.8%-2.0%,respectively. CONCLUSION: The method is rapid,accurate and reliable.It can be used to control the quality of Yiqing Capsule.