Objective:To investigate the effect of simvastatin on cardiomyocyte apoptosis and cardiac dysfuction after myocardial infarction.Method:Simvastatin was administrated to the rats with myocardial infarction which was modeled by left anterior descending coronary artery ligation. After 7days, the apoptotic myocyte cells were quantified by TUNEL staining;left ventricular function index was measured by echocardiography and the level of serum lipid was measured by biochemical method.Results:Compared with infarction group, apoptotic myocyte cells in simvastatin group significantly decreased in infarction zone,border zone and non-infarction zone(P0.05).Conclusion:Simvastatin inhibits cardiomyocyte apoptosis and improves cardiac function after myocardial infarction.

Objective To investigate the clinical manifestations and imaging features of moyamoya disease (MMD).Method The clinical manifestations and the results of CT angiography ( CTA ) and digital subtraction angiography (DSA) examinations of 162 cases diagnosed with M MD were analyzed retrospectively.Results In 162 patients with MMD, 132 cases (81.48% ) had stroke, in which cerebral infarction and transient ischemic attack (TIA) were 20 cases, intraventricular hemorrhage were 48 cases, cerebral hemorrhage were 52 cases, subarachnoid hemorrhage (SAH) were 10 cases and acute subdural hemorrhage were 2 cases; 8 cases(4.94%) had simple migraine and 22 cases(13.58%) had simple epilepsy.All the patients were with typical imaging findings: ( 1 ) The central branch of the internal carotid artery,bilateral internal carotid artery clinoid segment and proximal arterial stenosis or occlusion was the main performance of MMD.(2) Abnormal vascular network in the skull base was the most feature of MMD changes.(3) The performance of collateral circulation.Conclusions CTA and DSA can be used for the diagnosis of MMD patients.DSA is the gold standard for diagnosis of MMD.

Arterioportal shunt often occurs in hepatocellular carcinoma of advanced stage, with obvious decrease of the survival rate. The proper management of arterioportal shunt correlates directly with patient's prognosis. This comprehansive article reviews the interventional management of arterioportal shunt for hepatic carcinoma from literatures during recent years. (J Intervent Radiol, 2006, 15: 312-314)

Injection Stauntoniae (IS ) was applied ou a part of the saphenous nerve of rat 4mm in length. With 50% IS, amplitudes of A??, A? and C components of the compound action polential were reduced and their latencics were delayed. In particular, the amplitudcs of A? and C components reduced to 47.0% ? 23.o% and 44.0?20.0% (MEAN?SD, n = 8, P

To investigate the prevalence and the antibiotic resistance of bacteria isolated from 25 miniature pigs. 45 bacterial strains were isolated, which were identified by biochemical assays, amplification of 16S rRNA genes by PCR and sequence analysis, and were evaluated for resistance to 30 antibiotics. The identification results showed that these bacteria belonged to Campylobacter (Campylobacter jejuni), Helicobacterium (Helicobacter pylori), Klebsiella (Klebsiella pneumoniae), Escherichia (Escherichia coli, Escherichia fergusonii), Pseudomonas (Pseudomonas aeruginosa), Stenotrophomonas (Stenotrophomonas maltophilia), Staphylococcus (Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus simulans), Streptococcus (Streptococcus pneumoniae, Streptococcus suis, Streptococcus vestibularis, Streptococcus mitis, Gemella measles, Aerococcus viridans) and Bacillus (Bacillus subtilis, Bacillus licheniformis, Bacillus alvei, Bacterium megaterium). These bacteria were all susceptible to aztreonam and cephalothin. However, the resistence to furazolidone was found. Microbial population carried by miniature pigs in China had characters of diversity. Results of this study provided scientifical accordance for the microorganism monitoring of miniature pigs in China.

Adult ; Carcinosarcoma ; pathology ; Female ; Heart Neoplasms ; pathology ; Humans ; Lung Neoplasms ; pathology ; Myocardium ; pathology

Objective The questionaires of the ONFH aegers who were hospitalized in Kanggu hospital,during 2005-2008 ,were collect-ed to evaluate the therapeutic effects of acupotomy by proper statistical methods. Methods Four indexes according to the criteria of Therapeutic effect of adult ONFH recovery and reconstruction (ZHAO Dewei, 1996) were measured to evaluate the effect of the treatment. Results Monofac-torial analysis showed that the treatrnent was effective,but some phenomena could not be correctly explined in specialized field. This problem was re-solved appropriately by structural equation model(SEM). Conclusion By the method of SEM, the confounding factors could be better controlled and the evaluation was more reliable.

Objective To study the relationship between mutation of rpsL drug-resistant gene in L-forms of Mycobacterium tuberculosis and drug-resistance to streptomycin in pneumoconiosis patients.Methods A total of 52 clinical isolated strains of Mycobacterium tuberculosis L-forms were collected from 97 pneumoconiosis patients.The mutation of rpsL gene was detected by PCR-SSCP,and the drug-resistance to streptomycin was performed by routine antimicrobial susceptibility test(AST).Results The results of drug susceptibility test showed that 26 in the 52 clinical isolated strains were drug-resistant to streptomycin.The streptomycin-resistant rate was 50.00%(26/52).The gene mutation rate of rpsL detected by PCR-SSCP was 40.38%(21/52).The coincidence rate of two experimental results was 80.77%(21/26).Conclusion High detectable rate of streptomycin-resistant strains in Mycobacterium tuberculosis L-forms was found by PCR-SSCP.The application of PCR-SSCP may possess important value for guiding clinical medication of pneumoconiosis patients complicated with tuberculosis among coal workers

Objective To study the analysis of non-small cell lung cancer patients with multiple brain metastases with erlotinib combined with whole brain radiation therapy clinical observation and effect of C on vascular endothelial growth factor level. Methods 40 cases of non - small cell lung cancer patients with multiple brain metastases treated in Taizhou tumor hospital from January 2015 to April 2016 were selected and randomly divided into the control group and the experimental group, with 20 patients in each group. The control group and the experimental group patients were given clinical treatment of whole brain radiotherapy, the control group was given routine treatment, the experimental group received erlotinib. The clinical effects of the 2 groups were compared and analyzed. Results After the corresponding treatment, the experimental group of 20 patients, 8 cases of complete remission, 7 cases of partial remission, the number of effective treatment for 15 cases, the treatment rate was 75.0％. Of the patients in the control group, 6patients had complete remission, and 4 patients had partial remission. The effective rate was 50％. Available, the effective rate of the treatment group (75.0％) was significantly higher than that of the control group (50.0％), with statistical difference (P<0.05). The survival rate of the experimental group after one year (80.0％) was significantly higher than that of the control group (60.0％), with statistical difference (P<0.05). The level of vascular endothelial growth factor (C) in the experimental group was significantly lower than that in the control group (P<0.05). Conclusion Non small cell lung cancer patients with multiple brain metastases with erlotinib combined with radiotherapy in the clinical treatment effect of whole brain is better, can improve the survival rate in a large extent, improve the endothelial growth factor C levels, with the further promotion of the clinical significance.

Leptospirosis is recognized as an important emerging zoonotic disease caused by pathogenic Leptospira spp.and has a serious impact on people′s health and animal husbandry.Therefore, it has attracted more and more attention.With the development of biotechnology, major breakthroughs have been made in the fields of pathogenicity, molecular epidemic features and evolution mechanism of Leptospira.In this review, we summarize progress in evolution and molecular typing of Leptospira at home and abroad in order to provide a reference for further research on molecular epidemiological surveillance and new vaccine development.