Biomedical Research ; trends ; Humans ; Liver Neoplasms

Dental Implantation, Endosseous ; Humans ; Tooth Socket ; surgery

China ; Dental Implants ; Health Services Needs and Demand ; Humans ; Periodontics ; manpower

The multiple primary carcinoma (MPC) is defined as more than 2 or up carcinomas occured with in same or multiple organs in an individual.Along with the science development and advancement of human society,the life-span of human being has been prolonged,and more of MPC are identified.But the misdiagnosis of MPC as the metastases of primary tumors or missed diagnosis will mislead therapeutic regimens and exacerbate the diseases.Therefore,the accurate differentiation of MPC is becoming increasingly important.This article mainly reviews the epidemiology,diagnostic criteria,etiology,frequent sites of involvement,classification,and diagnostic protocols of MPC.

ObjectiveTo investigate the value of S100B protein in the evaluation of prognosis for patients with severe brain injury.MethodsThe serum S100B protein concentration was determined by enzyme-linked immunosorbent assay in 86 patients with severe brain injury(observation group) and 89 healthy individuals(control group) from February 2009 to March 2011.The clinical symptom and Glasgow outcome scale(GOS) score were measured.ResultsIn the 86 patients of observation group,33 patients were with good-recovery,25 patients were with moderate-deficit,14 patients were with severe-deficit,1 patient was detected of persistent vegetative status,and 13 patients died.The rate of excellent prognosis and worse prognosis were 67.4％ (58/86) and 32.6％ (28/86).The concentration of S100B protein was obviously higher in observation group [ ( 1.42 ± 0.42 ) μ g/L ] than that in control group [ (0.16 ± 0.05 ) μ g/L ] in 24 hours (P ＜ 0.01 ).The concentration of S100B protein in worse prognosis [ (2.15 ± 0.51 ) μ g/L] was obviously higher than that in excellent prognosis [ ( 0.92 ± 0.49) μ g/L ] ( P ＜ 0.05).ConclusionsS100B protein has high sensitivity and specificity to evaluate brain injury,and it is a reliable and valid biochemical marker of the brain damage.It has important clinical value in the evaluation of severity and prediction of prognosis for patients with severe brain injury.

ObjectiveTo explore the effect and surgical management of the internal fixation with double steel plate by the olecranon osteotomy approach in the treatment of severe condyle humeral intercondylar splintered fracture.Methods50 patients with severe condyle humeral intercondylar splintered fractures were treated by double plate internal fixation through olecranon osteotomy.ResultsAll patients(50 cases) were followed up for 6 months to 2 years.The complications such as bone defect,ossifyingmyositis,tardive ulnar nerve compression,and internal fixation fail were not found.According to Aitken Rorabeck scale,the function of the elbow showed excellent in 35 cases,good in 9 cases,fair in 6 cases,the excellent and good rate was 88％.ConclusionThe internal fixation with double steel plate by the olecranon osteotomy approach in the treatment of severe condyle humeral intercondylar splintered fracture was a good approach.Anatomical reduction surgically reconstructed stabilization of the elbow and early active rehabilitation were crucial factors of functional rehabilitation of the elbow.

Objective To explore the clinical diagnosis value of colonoscopy and pathological examination for the etiology of colon and rectum ulcer.Methods 120 patients with colorectal ulcer were examined by colonoscopy and pathological examination,and differential diagnosed.Results The rate of endoscopic diagnosis combined pathological diagnosis for ulcerative colitis,tuberculosis,crohn's disease,amebic,chronic bacterium dysentery were different from the endoscopic diagnosis rate and pathological diagnosis rate,the differences were significant (x2 =12.37,13.58,15.02,17.77,18.39,P ＜ 0.05 ) ; In the nausea lymphoma,colorectal cancer,endoscopic diagnosis combined pathological diagnosis with quite a statistically significant difference between the rate of endoscopic diagnosis( x2 =10.95,11.40,P ＜ 0.05 ).Conclusion For the colorectal ulcer disease,colonoscopy combined pathological examination was an ideal means of inspection.

Objective To explore the clinical signifcance of changes of serum Ang Ⅱ,hs-CRP and BNP levels and the relationship with atrial fibrillation(AF),and the risk factors of AF recurrence.Methods 100 patients with AF were selected in this study,and they were divided into two groups:paroxysmal atrial fibrillation group (n =54),durative atrial fibrillation group(n =46),and 50 healthy subjects were selected as control.The levels of serum Ang Ⅱ,BNP were detected by radioimmunoassay,and hs-CRP was detected by immunoturbidimetry.Results The levels of Ang Ⅱ,hs-CRP and BNP in atrial fibrillation patients were significantly increased as compared to control group (P ＜ 0.01).The levels of Ang Ⅱ,hs-CRP in the durative atrial fibrillation group were higher than those in the paroxysmal atrial fibrillation group.The levels of serum Ang Ⅱ,hs-CRP were positively correlated with serum BNP level (r =0.563,0.678,all P ＜0.01).The level of serum Ang Ⅱ was positively correlated with serum hs-CRP level(r =0.626,P ＜ 0.01).Multiple logistic regression analysis revealed that hs-CRP and BNP were the important risk factors of atrial fibrillation recurrence[OR value =2.42,95％ CI(1.84 ～ 5.26) ;OR value =2.14,95％ CI(1.37 ～.86)].Conclusion The serum AngⅡ,hs-CRP and BNP may play important roles in the development of AF.hs-CRP and BNP may be the independent risk factors of AF.The detection of hs-CRP and BNP may be related to recurrence prognosis in patients with AF.

Objective To probe the relationship on TCM syndromes and related index of metabolic syndrome.Methods 1124 people who receive physical examination were undertaken TCM syndrome differentiation,and five viscera syndromes,the deficiency syndromes,excess syndromes,cold and heat syndromes were found.The relations between TCM syndromes and waist circumference,triglycerides,high-density lipoprotein,blood pressure,fasting blood glucose were studied.Results ①The deficiency syndrome groups and the groups of metabolic syndrome related index by clustering analysis had a higher consistency.②Discriminated analysis demonstrated waist circumference,high-density lipoprotein,and diastolic blood pressure could be used to determine liver syndrome.Blood sugar could be used to determine kidney syndrome.Waist could distinguish blood deficiency syndrome.Blood glucose and systolic blood pressure could distinguish Yin deficiency syndrome.Systolic blood pressure could determine Qi stagnation syndrome.Siastolic blood pressure could determine heat syndrome.The liver syndrome group and the actual liver syndrome group had higher consistency by discriminated analysis.After establishing the discriminated equation,total correct rate of distinguishing were 57.3％,67.1％,63.8％,61.5％,52.4％,47.2％.③Receiver operating characteristic curve analysis showed that blood glucose had diagnostic significance to renal syndrome.The area under the curve was 0.562.Triglycerides,blood glucose,blood pressure had diagnostic significance to Yin deficiency syndrome.The areas under the curve were 0.541,0.556,0.580 and 0.569.Waist circumference,triglycerides,high-density lipoprotein had diagnostic significance to moisture syndrome.The areas under the curve were 0.622,0.609 and 0.605.Diastolic blood pressure had diagnostic significance to heat syndrome.The area under the curve was 0.544.Conclusion By the multifarious analytical methods,we can see that syndromes have more contacts to related index of metabolic syndrome.