Objective To investigate the relationship between IL-6-174C/G and-572C/G site gene polymorphism with nonvalvular atrial fibrillation(NVAF) as well as the national differences of interleukin-gene polymorphism between Kazak and Han nationality in Xinjiang region.Methods Seventy-nine Kazak patients of NVAF(Kazak NVAF group),78 Han patients with NVFA (Han NVAF group),75 Han cases of non-AF and 79 Kazak cases of non-AF were selected in Xinjiang region.The venous bloods were collected from extracting DNA.IL-6 gene-174G/C and-572C/G polymorphism in various groups were analyzed by adopting the PCR-RFLP technique.Results The allele frequency of IL-6-572G/C site G in the NVAF group was significantly higher than that in the control group(x2 =4.076,P＜0.05).The allele frequency of IL-6 gene-572 G/C site G had statistical difference between the NVAF group and the control group(OR=1.519,95 ％CI:I.087-2.122,P＜0.05),but the distribution difference between the Han and Kazak control groups had no statistical significance(P＞0.05);the advanced age ≥75 years old)(OR=6.468,95 ％CI:2.427-17.240) and left atrial dimension(OR =1.053,95 ％ CI:1.022-1.085) were the independent factors of AF occurrence;the left ventricular ejection fraction was a protective factor for preventing AF occurrence.The allele frequency of IL-6 gene 174G/C site C and G had no statistical difference among various groups(P＞0.05).Conclusion The allele of IL-6-572 G/C site G is a risk factor of genetic predisposition in NVAF.IL-6-174G/C site gene polymorphism has no relation with the susceptibility of AF.

Objective To analyze the influencing factors of coronary artery lesions in patients with Ka-wasaki disease(KD)in Xinjiang.Methods A total of 1 500 KD patients who were treated in the First Affilia-ted Hospital of Xinjiang Medical University from December 2020 to December 2022 were selected as the re-search objects.According to whether coronary artery disease occurred,they were divided into two groups.886 patients with coronary artery lesions were included in the experimental group,and 614 patients without coro-nary artery lesions were included in the control group.Univariate and multivariate logistic regression analysis was used to analyze the risk factors of coronary artery lesions.Results The results of logistic regression anal-ysis showed that the duration of fever(＞10 d),high Gensini score,high level of N-terminal pro-brain natri-uretic peptide(NT-proBNP),C-reactive protein(CRP),total cholesterol(TC),low-density lipoprotein cho-lesterol(LDL-C)and triglycerides(TG)may be risk factors for coronary artery lesions(P＜0.05).Conclusion In clinical diagnosis and treatment,targeted intervention should be given as early as possible to prevent the occurrence of coronary artery lesions.