1.Outcome evaluation of introducing the Japanese version of the Liverpool Care Pathway for patients with cancer in a general ward
Takaaki Hasegawa ; Mio Taguchi ; Nanori Kuzuya ; Yasuyuki Sugiyama
Palliative Care Research 2015;10(4):315-320
This study sought to determine whether the Japanese version of the Liverpool Care Pathway (LCP-J) could improve nurses’ practice in dying-phase and difficulties with palliative care in a general ward. Between July 2014 and June 2015, LCP-J intervention and educational program for nurse were introduced in a general ward. The primary aims of this study were to clarify the changes in self-reported practice and difficulties of nurse before and after the interventions. Self-reported practice and difficulties were measured using Palliative Care Self-Reported Practice Scale (PCPS) and Palliative Care Difficulty Scale (PCDS), respectively. The secondary aim was to clarify the defference in treatment, care and examination within last 48 hours between LCP-J patients and non-LCP-J patients. We obtained 21 responses in pre-intervention and 22 responses in post-intervention surveys from eligible nurses. Significant improvements were noted on domain of dying-phase care in PCPS and domain of alleviation of symptom in PCDS (3.00±1.16 versus 3.52±0.61 [p=0.042], 3.56±0.78 versus 3.10±0.63 [p=0.015], respectively). LCP-J was used for 9 dying cancer patients (40%), and no significant difference in treatment and examination within last 48 hours between LCP-J patients and non-LCP-J patients. LCP-J in general ward may improve nurses’ practice in dying-phase and difficulties with alleviation of symptom. In addition, considering the burden of LCP-J, to develop a useful checklist and educational interventions for dying patients is promising.
2.Report on Group Study about Audio-visual Teaching Technology
Shigeru HAYASHI ; Kenichi UEMURA ; Nobutaka DOBA ; Masahiko HATAO ; Motokazu HORI ; Kazumasa HOSHINO ; Saichi HOSODA ; Hitoshi ISHIKAWA ; Tsutomu IWABUCHI ; Taketoshi SUGIYAMA ; Susumu TANAKA ; Yasuyuki TOKURA
Medical Education 1983;14(3):209-213
4.Aspergillus oryzae S-03 Produces Gingipain Inhibitors as a Virulence Factor for Porphyromonas gingivalis.
Narandalai DANSHIITSOODOL ; Hideyuki YAMASHITA ; Masafumi NODA ; Takanori KUMAGAI ; Yasuyuki MATOBA ; Masanori SUGIYAMA
Journal of Bacteriology and Virology 2014;44(2):152-161
Oral infection with Porphyromonas (P.) gingivalis causes periodontitis that is manifested by the destruction of gingival connective tissues. Although a few types of antibiotics are effective against the infection, its use induces the appearance of drug-resistant bacteria. The present study shows that the fermented product of Aspergillus (A.) oryzae S-03, cultivated on the fat-removed soybean, inhibits the cell growth of the P. gingivalis. Likewise, the fermented product of the S-03 strain cultured for 26~42 h displays an inhibitory activity to gingipain as a virulence factor of P. gingivalis. The activity is not lost even with heat treatment at 100degrees C for 15 min. We also demonstrate that the S-03 strain exhibits high protease activity. In addition, the strain does not produce aflatoxin because of the loss of a regulatory gene, aflR, necessary for the toxin biosynthesis.
Aflatoxins
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Anti-Bacterial Agents
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Aspergillus
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Aspergillus oryzae*
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Bacteria
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Connective Tissue
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Genes, Regulator
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Hot Temperature
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Oryza
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Periodontitis
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Porphyromonas
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Porphyromonas gingivalis*
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Soybeans
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Virulence*