1.Clinical Application of Moxibustion by Thermo-modules (Heating-Cooling) Meiji Acupuncture-moxibustion Junior College
Journal of the Japan Society of Acupuncture and Moxibustion 1981;31(1):51-54
In order to, when administering moxibustion therapy, reach the effective temperature as quickly as possible with as litte as possible injury to the surface of the skin, we devised a heat-sense moxibustion apparatus using thermo-modules.
In patients such as those with a predisposition to diabetes mellitus, there is a danger that a burn on the surface of the skin may cause serious complications. The use of this apparatus limits or removes such dangers and makes it possible to elevate the therapeutic results. This apparatus, in order to reduce burn injuries immediately switches to cooling when the effective heat stimulation level is reached, thus continuous burn therapy is being administered.
We will report on the influences on the sugar tolerance capacity at the time of stimulation at ST-36 using this machine.
2.Treatment with complementary oriental medicine for two cases of paralysis
Yu SATOH ; Yutaka SHINOHE ; Ken-ichi SATOH ; Nozomu SAKAMOTO ; Yasuo IMAI ; Shigeharu JOH
Journal of the Japan Society of Acupuncture and Moxibustion 2007;57(1):25-30
We experienced two cases of paralysis in the facial area treated with complementary oriental medicine.
Case 1
A 68-year-oid female presented herself in the emergency department at the Iwate Medical University with a complaint of facial deformity.
She was diagnosed as left facial paralysis with ptosis and drooping of a corner of the mouth.
In our clinic, she was first treated with stellate ganglion block, steroids and antivirals.
One week later, we adopted trans-cutaneous electric stimulation therapy and 2 months later used acupuncture. All the symptoms disappeared over a 9 month period.
Case 2
A 49-year-old female was referred to Iwate Medical University Department of Oral Maxillo-facial Surgery because of her facial itching and hypesthesia.
She was diagnosed as herpes zoster and transferred to our clinic. She was treated with stellate ganglion block, trans-cutaneous electric stimulation therapy and steroids.
One month later, her symptoms were partially lessened.
Two months later, a diagnosis of peripheral trigeminal nerve paralysis of the fist, second and third divisions, was established after a complete medical examination.
After that, her paresthesia gradually changed neuralgia-like in spite of our clinical care.
Five years later, her symptoms improved to a certain extent with the use of acupuncture.
Conclusion
We conclude that oriental medicine is effective in the treatment of paralysis.
3.Real-world data for golimumab treatment in patients with ulcerative colitis in Japan: interim analysis in post-marketing surveillance
Shiro NAKAMURA ; Teita ASANO ; Hiroaki TSUCHIYA ; Kanami SUGIMOTO ; Yuya IMAI ; Seiji YOKOYAMA ; Yasuo SUZUKI
Intestinal Research 2022;20(3):329-341
Background/Aims:
Golimumab (GLM) is an anti-tumor necrosis factor-α drug approved for treating moderate-to-severe active ulcerative colitis (UC). A 52-week post-marketing surveillance (PMS) was initiated to evaluate its safety and effectiveness in patients with UC in Japan. We present an interim report of the ongoing PMS.
Methods:
Patients received 200 mg of subcutaneous GLM at week 0, 100 mg at week 2, and 100 mg 4 weekly thereafter. The safety analysis set included 392 patients with UC, and the effectiveness analysis set 387 patients. Safety and effectiveness were assessed at week 6.
Results:
Adverse drug reactions (ADRs) were reported in 8.2% (32/392) and serious ADRs in 4.6% (18/392). The most frequent ADRs were infection and infestation (3.3%), with herpes zoster being the most common. ADRs were significantly higher in patients with concomitant corticosteroid use (odds ratio [OR], 3.45; 95% confidence interval [CI], 1.40–9.68). No significant difference in ADR incidence was observed between patients aged ≥65 and <65 years (OR, 1.23; 95% CI, 0.35–3.47). Six-week effectiveness of GLM was confirmed by a decrease in the partial Mayo score (–2.3; 95% CI, –2.6 to –2.1) and C-reactive protein levels (–0.64; 95% CI, –0.92 to –0.36), including in the biologics-experienced population.
Conclusions
The safety and effectiveness of GLM at week 6 in a real-world setting were demonstrated in patients with UC in Japan. ADR patterns were consistent with previous reports with no new safety signals. Concomitant corticosteroid use may be associated with increased ADR incidence. The final results of the ongoing PMS are necessary for further evaluation.
4.A Case of Concomitant Extra-Anatomic Bypass to Both Femoral Arteries with Central Repair in a Patient with Aortic Dissection Complicated Ischemia in the Lower Extremities
Shinichi IMAI ; Masahiro UENO ; Keisuke YAMAMOTO ; Hironori INOUE ; Yasuo MORISHITA
Japanese Journal of Cardiovascular Surgery 2019;48(2):142-146
We report a case of aortic arch replacement and extraanatomic bypass from a branched graft to both bifemoral arteries in a patient with aortic dissection complicated by ischemia in the lower extremities. A 61-year-old woman was found to have thrombosed type II aortic dissection by enhanced computed tomography (CT). Because she had no clinical symptoms, we chose conservative pharmacotherapy. A year later, she suddenly felt severe back pain and dyspnea. CT demonstrated type IIIb aortic dissection. She developed lower extremity ischemia because the true lumen in the abdominal aorta was severely compressed by the false lumen. Two weeks after onset, we planned a bilateral axillo-femoral bypass because the right lower limb ischemia had worsened, with severe pain. However, CT showed ascending aortic dissection. Hence, emergency graft replacement of aortic arch was required. A T-shaped graft was anastomosed to the bilateral femoral arteries, and was used as a delivery line during cardiopulmonary bypass. Although distal anastomosis of the arch was constructed only to the true lumen, leg ischemia persisted. Therefore, the T-shaped graft was connected to the branched graft used for antegrade systemic perfusion. We used INVOS as an indicator of intraoperative lower limb ischemia, which was useful for judging whether or not revascularization of lower extremity was achieved. After the operation, the bypass graft was patent, and ischemia in the lower extremities disappeared.