2.Acute Oral Toxicity Test of Hot Water Extract of Coix lacryma-jobi L. var. ma-yuen Stapf in Rats
Hirotaka HAYASHI ; Yasuyuki OHTA ; Takanari ARAI ; Yasuko SHIMANO ; Fumihide TAKANO ; Jeffry Michael STRONG ; Toshiki ENOMOTO ; Kazuo UEBABA ; Tomihisa OHTA ; Nobutaka SUZUKI
Japanese Journal of Complementary and Alternative Medicine 2009;6(2):105-110
Coix lacryma-jobi L. var.ma-yuen Stapf (Coix seed) is a grass crop that has long been used in traditional medicine as a nourishing food. However, high-intake safety of the extract of the husks, pellicles and astringent skin of Coix seed has rarely been evaluated. We performed a safety test of hot water extract of all parts of Coix seed (CRD extract) in rats. CRD extract showed no significant toxicity on body weight, blood analyses, urinalysis and histopathological examination in acute toxicity tests.
3.28-day Repeated Dose Oral Toxicity Test of Coix lacryma-jobi L. var. ma-yuen Stapf in Rats
Hirotaka HAYASHI ; Takanari ARAI ; Jeffry M. STRONG ; Harukuni TOKUDA ; Yasuko SHIMANO ; Yasuyuki OHTA ; Toshiki ENOMOTO ; Kazuo UEBABA ; Tomihisa OHTA ; Nobutaka SUZUKI
Japanese Journal of Complementary and Alternative Medicine 2009;6(3):131-135
Coix lacryma-jobi L. var.ma-yuen Stapf (coix seed) is a grass crop that has long been used in traditional medicine as a nourishing food. However, high-intake safety of the extract of the husks, pellicles and astringent skin of coix seed has rarely been evaluated. We performed a 28-day repeated dose oral toxicity test of hot water extract of all parts of Coix seed in rats. The extract showed no significant toxicity on body weight, blood analyses, urinalysis and histopathological examination in acute toxicity tests.
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