Objective The purpose of the study was to explore influence of family factors on dietary behavior of primary and secondary studen t s in Guangzhou city, in order to provide suggestions for intervention of dietary behavi or. Methods The study population included 1 539 student-parent s pairs selected from Guangzhou city by using the method of stratified multistage cluster random sampling, and data were collected through questionnaires. Results The ratio of parents who often reminded and forced the ir children to eat some fo od they thought of as nutrition were 56.0% and 7.7%, and 39.7%, 29.2% of ch ildren complied with their parents, respectively. At dinner, 14.8% and 27.5% of parents often and sometimes criticized their children, and the ratio of childre n couldn't eat anything and only eat a little food were 5.9%,19.3%, respectively . Forty-two point three of primary and secondary school students watched televi sion wh en they had a dinner, which made 39.4% of students not eat seriously. C onclusions Dietary behavior of primary and secondary school students is influenced strongly by their parents and family environment, it is necessary for parents and themselves to grasp enough nutritional knowledge.

Cryptococcosis ; Humans ; Liver ; microbiology ; Liver Diseases ; microbiology

Objective To observe the clinical efficacy and toxicity of intraperitoneal chemotherapy combined with intravenous chemotherapy in treatment of cervical cancer.Methods The experimental group of 40 patients received systemic chemotherapy of docetaxel and cisplatin combined abdominal intraperitoneal high-frequency hyperthermia in the control group,40 patients received docetaxel plus cisplatin chemotherapy,The efficacy and toxicity were observed.Results The complete remission rate of observotion group was 82.5％,significantly higher than 62.5％ in control group.Effective rate in observation group was 92.5％ and also significantly higher than 75.0％ in control gronp.After 6 cycles of chemotherapy,the improvement of the experimental group was 85.0％ higher than 57.5 ％ in control gronp.The differemles between the two groups was statistically significant(P ＜ 0.05); the main side effects during chemotherapy are gastrointestinal reactions,since the cells decreased,hair loss,the difference was not statistically significant(P ＞0.05).Conclusion The chemotherapy of docetaxel and cisplatin intraperitoneal chemotherapy can significantly improve the treatment of cervical cancer,without increasing side effects.

Objective To analyze the clinicopathologic characteristics of atypical polypoid adenomyoma (APA) of endometrium,and investigate the special characteristics of cancerous transformation from APA.Methods Fourteen cases of APA were collected in General Hospital of People' s Liberation Army from January 2007 to March 2013.The clinical data,morphologic features,immunohistochemistry and the related literature were reviewed.Results The median age of the 14 patients was 38 years (ranged from 23 to 72 years),only 1 patient was postmenopausal.The most common symptom was irregular vaginal bleeding (4/14),and 4 patients were identified during routine physical examination for infertility.Among 14 cases,4 cases were diagnosed as well differentiated endometrioid adenocarcinoma originating from APA,and their median age was 35 years (ranged from 28 to 41 years); color Doppler flow imaging (CDFI) of ultrasound showed rich blood flow signal.The tumors with cancerous components were obviously larger than the usual APA (mean diameter:4.7 versus 1.8 cm).Histologically,irregular and branched glands were embedded in fibromuscular stroma and the glandular epithelium were atypical hyperplasia in varying degrees.While carcinoma developed in the APA,the sieve,solid and papillary structures were noticeable,and necrosis were common.Conclusions APA is a rare lesion of the uterus.Although the clinical behavior is benign in most cases,there may be possible for some cases developing carcinomas.If the APA mass is more than 4 cm in diameter,and microscopically demonstrates prominent sieve,solid,papillary structures and necrosis,the diagnosis of carcinoma developed from APA can be made.Thorough analysis should be done before the most proper therapeutic regimen is drawn up.

Objective To investigate the influence of hyperlipidemia on clinical and pathological characteristics of mild to moderate proteinuria patients with IgA nephropathy.Methods A total of 529mild to moderate proteinuria patients with IgA nephropathy were selected and divided into hyperlipidemia group and normal lipid group according to serum lipid level.The clinical manifestations and pathological differences were analyzed and compared between two groups.The clinical and pathological characteristics of patients with different levels of urinary protein were compared as well.Results Compared with the normal serum lipid group,body mass index in patients with hyperlipidemia group (BMI),systolic blood pressure,diastolic blood pressure,uric acid (UA),24 h urinary protein significantly increased,while tubular atrophy,interstitial fibrosis,renal interstitial inflammatory cell infiltration degree were heavy (P ＜ 0.05).Pearson correlation analysis showed that hyperlipidemia group total cholesterol (CHOL) and 24 h urinary protein and systolic pressure was positively correlated with serum albumin (ALB).Triglyceride (TG) and 24 h urinary protein,BMI and estimated glomerular filtration rate (eGFR) were positively correlated.High density lipoprotein cholesterol (HDL) was negatively correlated with BMI,ALB,UA and diastolic blood pressure.In patients with2 4 h urinary protein in 1 to 3.5 g,2 3 9 patients (7 6.6 ％) had hyperlipidemia,and compared with normal blood lipid,the BMI,systolic blood pressure,diastolic blood pressure,UA,2 4 h urinary protein significantly increased,while mesangial proliferation,mesangial cell hyperplasia were severe (P ＜0.05).In patients with 24 h urinary protein less than 1 g,132 patients had hyperlipidemia (60.7％),and compared with the normal blood lipids,the BMI and UA were elevated,smoking and drinking were common,and the degree of interstitial fibrosis was serious (P ＜0.05).Conclusion The BMI,blood pressure,UA,24 h urinary protein significantly increase in patients with hyperlipidemia,and renal tubular atrophy,interstitial fibrosis,renal interstitial inflammatory cell infiltration are more severe.In the patients with 24 h urinary protein in 1 to 3.5 g,the incidence rate of hyperlipidemia is higher than that in the patients with 24 h urinary protein less than 1 g.

Objective To investigate the influence of hyperlipidemia on clinical and pathological characteristics of mild to moderate proteinuria patients with IgA nephropathy.Methods A total of 529mild to moderate proteinuria patients with IgA nephropathy were selected and divided into hyperlipidemia group and normal lipid group according to serum lipid level.The clinical manifestations and pathological differences were analyzed and compared between two groups.The clinical and pathological characteristics of patients with different levels of urinary protein were compared as well.Results Compared with the normal serum lipid group,body mass index in patients with hyperlipidemia group (BMI),systolic blood pressure,diastolic blood pressure,uric acid (UA),24 h urinary protein significantly increased,while tubular atrophy,interstitial fibrosis,renal interstitial inflammatory cell infiltration degree were heavy (P ＜ 0.05).Pearson correlation analysis showed that hyperlipidemia group total cholesterol (CHOL) and 24 h urinary protein and systolic pressure was positively correlated with serum albumin (ALB).Triglyceride (TG) and 24 h urinary protein,BMI and estimated glomerular filtration rate (eGFR) were positively correlated.High density lipoprotein cholesterol (HDL) was negatively correlated with BMI,ALB,UA and diastolic blood pressure.In patients with2 4 h urinary protein in 1 to 3.5 g,2 3 9 patients (7 6.6 ％) had hyperlipidemia,and compared with normal blood lipid,the BMI,systolic blood pressure,diastolic blood pressure,UA,2 4 h urinary protein significantly increased,while mesangial proliferation,mesangial cell hyperplasia were severe (P ＜0.05).In patients with 24 h urinary protein less than 1 g,132 patients had hyperlipidemia (60.7％),and compared with the normal blood lipids,the BMI and UA were elevated,smoking and drinking were common,and the degree of interstitial fibrosis was serious (P ＜0.05).Conclusion The BMI,blood pressure,UA,24 h urinary protein significantly increase in patients with hyperlipidemia,and renal tubular atrophy,interstitial fibrosis,renal interstitial inflammatory cell infiltration are more severe.In the patients with 24 h urinary protein in 1 to 3.5 g,the incidence rate of hyperlipidemia is higher than that in the patients with 24 h urinary protein less than 1 g.

This article interprets the " Screening for and Managing the Person with Frailty in Primary Care: Guidelines " developed in 2020 by the International Conference on Frailty and Sarcopenia Research (ICFSR) . This article also analyzes the characteristics of frailty assessment tools and management strategies for frail elderly in order to provide new ideas for the assessment and management of frail elderly in China, and achieve healthy aging of the elderly.

Objective To investigate the clinical and histopathological features of cervical basal squamous cell carcinoma (BSCC). Methods A retrospective analysis of 10 cases of cervical BSCC was carried out. The clinical data and all the pathological sections were reviewed, the related immunohistochemical results were statistically analyzed, the clinicopathological features were analyzed, and then followed the prognosis. Results (1) Clinical features:the median onset age of BSCC in cervix was 51 years old (ranged 35-69 years old), 5 of them were postmenopausal women. Vaginal bleeding was often seen in clinic (7 cases). Of the 10 cervical BSCC patients, 5 tested HPV types. All of them were HPV positive, including 2 cases of HPV 16 positive and 1 case of high-risk HPV positive. At the time of colposcopy, 3 cases showed exogenous nodular mass, 3 cases showed endogenous infiltrating mass, and 4 cases had unclear type of mass.(2)Treatment:of the 10 patients, 8 underwent hysterectomy+bilateral adnexal excision+pelvic lymphadenectomy, of which 6 underwent radiotherapy or chemotherapy after operation. Radiotherapy and chemotherapy were performed only in 2 cases. (3) Pathological features: histologically, the tumor cells were nests and stripe like growth, which were composed of basal like tumor cells. The cells had obvious heteromorphosis, less cytoplasm, deep dyed nuclei and common nuclear mitosis, and there were often palisade like structures around the cell nests, and some cells in the center of the cell nests were found to have acne like necrosis. It could be mixed with normal squamous cell carcinoma and squamous epithelial lesion. Among the 10 patients, 6 had immunohistochemical results. BSCC mainly expressed p16 and squamous cell markers such as p63, cytokeratin (CK) 5/6 and p40 protein, the positive expression rates were 3/3, 3/3, 2/2 and 3/3, respectively.A few expressed CK7 protein, and the positive expression rate was 1/3. (4) Prognosis:follow-up time ranged from 1 week to 64 months, and 2 cases were lost to follow-up. Among the 8 follow-up patients, 3 had iliac bone, lung or skin metastasis, and 5 had no recurrence or metastasis during the follow-up period. Conclusions BSCC of cervix is a rare malignant tumor of cervix associated with high-risk HPV infection, p16 is more positive. The treatment is similar to that of normal cervical squamous cell carcinoma. Surgical resection and radiotherapy and chemotherapy are the most effective methods according to the clinical stage . At present, the disease is considered to be highly aggressive and the poor prognosis.

Objective: To investigate the ethical decision-making process of breaking confidentiality when counselors dealing with self-inflicted injury and suicide issues in college situation. Methods: A semi-structural interview was addressed to 10 counselors from 7 college counseling centers in Beijing, among whom with (10 ± 8) years of experience on average in this field. Content analysis method was used to transcription of the interviewing data. Results: Totally 8 counselors had received ethical training more or less, and attached great importance to ethical codes. There were still some conflicts between school regulations and confidentiality rules in 7 university counseling centers. Different counselors varied greatly in decision-making on breaking confidentiality when facing college students' self-inflicted injury and suicide. Faced with conflicts between college demands and confidentiality principles, counselors could take the professional standpoint and consider more of the interests of students. Conclusion: The decision-making process on self-inflicted injury and suicide confidentiality breakthrough needs to be standardized. College's attention and support to the counseling work should be strengthen and enhance ethical awareness.