OBJECTIVE:To provide a reference for innovative drugs to enter the health insurance directory smoothly and pro-mote the rapid development of pharmaceutical industry in China. METHODS:Based on related policy study of foreign and domes-tic innovative drugs entering the health insurance directory,the policy barriers of innovative drugs entering the health insurance di-rectory were analyzed and the countermeasures were put forward. RESULTS & CONCLUSIONS:In China,the foundation of drug selection was not objective enough;the review results were so vulnerable to subjective views because of the experts selection mech-anism;the health insurance directory deletion mechanism was deficient;the waiting time for innovative drugs entering the health in-surance directory was too long;innovative drugs negotiation mechanism was imperfect,etc. It is recommended that forcibly requir-ing pharmaceutical companies should provid the related data about pharmacoeconomic evaluation;the independence and pluralism of the expert group should be enhanced;drugs in the health insurance directory should be secondarily evaluated regularly;the inno-vative drugs should be given the green channel;innovative drug price negotiation rules should be unified to promote drug informa-tion sharing.

OBJECTIVE:To evaluate the economic efficiency of the Guangzhou government's free vaccination of influenza vaccine for elderly people over 60 years old from perspective of government,and to provide reference for decision-making depart-ment. METHODS:The static budget impact analysis model was constructed to estimate the healthcare expenses of self-paid vaccina-tion and free vaccination,and analyze the change of total government expenditure. RESULTS:The healthcare costs by government was estimated to be 40785594 yuan when the influenza vaccination was self-paid;it would rise up to 54744715 yuan when the government provided the influenza vaccine freely,so the government needed to invest more than 13959121 yuan each year,but in-fluenza patients could be reduced by about 39845 people. The sensitivity analysis showed that the health cost additionally invested by government was not more than 20 million yuan every year. CONCLUSIONS:It is economical for the government of Guangzhou to provide free vaccination for elderly people over 60 years old. If the government is financially affordable,it may consider providing free influenza vaccine for the elderly in the city so as to protect the elderly from influenza and its complications to a greater extent.