Objective To present the computed tomography (CT)findings and associated pathological features of eight cases of primary he-patic angiosarcoma (PHA).Methods All cases were confirmed by pathology.After a CT scan of the upper abdomen,all cases of PHA un-derwent enhanced scans in the arterial phase,portal venous phase,and delayed phase to observe the CT manifestations.The surgical speci-mens were subjected to conventional hematoxylin-eosin staining and immunohistochemistry and observed under a microscope.Results Of all patients,5 cases were massive type,2 cases were mixed type,and 1 case was multiple nodule type.CT scans revealed inhomogeneous low-density lesions,with necrosis of even lower density in the central part.In 4 cases of massive type,scattered high-density small pieces were observed in low-density areas;in one case of mixed type,high-density nodules were observed on the edge of mass.There were 7 ca-ses of peripheral nodular irregular enhancement in the arterial phase,including 1 case with flocculent central enhancement and another with no enhancement.Lesions remained enhanced in the portal venous and delayed phases,but 1 case had no enhancement.Five in 9 lesions had sharp edges in the arterial and portal venous phases,with“sharpen rim perpendicular to pleura”signs at the boundaries with the surrounding normal liver tissue.The outer edges of 7 lesions were found to have “pseudocapsules”in the portal venous phase.Conclusion CT scans showed a large hypodense lesion with irregular necrotic areas or scattered hemorrhage in PHA patients,whist enhanced scans showed a pro-gressive filling and necrotic area in the central part.There could be“sharpen rim perpendicular to pleura”and“pseudocapsule”signs at the edge.It might be helpful to improve the diagnosis through the above characteristic features.

Objective To compare the effects of aspirin and clopidogrel on platelet aggregation function by TEG,and to study the antiplatelet agents tailored therapy of Thrombelastography(TEG)in treatment of cerebral infarc-tion patients.Methods 100 patients with acute cerebral infarction were included in two groups:aspirin group and clopidogrel group.The inhibitory rates of AA and ADP receptor pathway in platelets were detected by TEG.The effect of inhibitory rates in group aspirin and clopidogrel was compared with nerve function and the recurrence rate of stroke. Results The inhibitory rates of group aspirin (85.23 ±21.98)% was higher than group clopidogrel (47.31 ± 22.37)% (t =7.340,P =0.005).The patients with which the inhibitory rates showed goodby TEG in group aspirin and clopidogrel got better neurological recovery,and the patients showed goodby TEG in group aspirin got lower stroke recurrence rate within 1 year(χ2 =4.460,P =0.035;χ2 =7.232,P =0.007).Conclusion TEG had guided the antiplatelet individual therapy for cerebral infarction patients,and can be used to predict and confirm the efficacy of antiplatelet drug.