Parkinson’s disease (PD) is a degenerative disease of the basal ganglia which caused tremor at rest, muscle rigidity and hypokinesia. The exact cause of PD is not clear so far, but what can be certain is that it has something to do with many factors. Administration of drugs is the major therapy for patients all over the world at present. This article introduces the characteristics of most of the drugs used in PD, as well as the trend of PD’s drug therapy.

BACKGROUND:BACKGROUND:Present studies have shown that bone cement have less osteoinduction and slow degradation in the body,so the effect of alone application is not satisfactory. Therefore,people have modified them,hoping to research a new materials that can overcome all shortcomings above-mentioned. OBJECTIVE:To investigate the ability of decalcified bone matrix (DBM) and acrylic bone cement (ABC) compound in filling and repairing bone defect,and to determine the best component proportion of the composition. DESIGN,TIME AND SETTING:Randomized controlled animal experiments were performed at the Experimental Animal Center,Chongqing Medical University from May to September 2008. MATERIALS:ABC and DBM were prepared into compound material at various proportions (2:8,3:7,4:6,5:5,6:4). METHODS:The animal models of bilateral femur bone defects and fillers were established in the New Zealand White rabbits. The complex material was implanted on the bone defect; the ABC was used as blank control group. MAIN OUTCOME MEASURES:The complex and alone materials were examined by biomechanics and scan electron microscopes. Gross observation,histopathological and X-ray test were used at 4,8,12 weeks after operation respectively to observe the repaired and filled status of bone defect. RESULTS:DBM composite quality of the scope of 3:7 -6:4,the composite materials that existed in more cracks more than 100 ?m,when the DBM was less than 3:7,the material inside the aperture and the majority of material was similar to ABC,mass ratio greater than 6:4 when the DBM and the ABC could not effectively together solidification. When the mass ratio was increased,which matrix particles of demineralized bone and ABC,the compressive ultimate strength of composite materials was less than pure ABC (P

Objective To compare the contraceptive efficacy, tolerability and bleeding patterns of Implanon and Norplant Methods One hundred healthy female volunteers received either Implanon (75 cases) or Norplant (25 cases) for 4 years, followed up with complain, bleeding patterns, hemoglobin, blood pressure, weight Record the time of insert and remove Results There were no pregnancies during the study Per 90 day reference period, the average number of bleeding spotting days with Implanon decreased from 33 day in the first period to 21 day in the last year, and Norplant decreased from 31 day to 20 day The average bleeding number of times was 2 25 of Implanon and 2 99 of Norplant per reference period( P

Coronary Artery Disease ; etiology ; therapy ; Humans ; Mucocutaneous Lymph Node Syndrome ; complications ; therapy

Female ; Humans ; Infant ; Male ; Mucocutaneous Lymph Node Syndrome ; Retrospective Studies

Child, Preschool ; Diagnosis, Differential ; Female ; Gonadotropin-Releasing Hormone ; therapeutic use ; Humans ; Hysteroscopy ; Pediatrics ; Puberty, Precocious ; diagnosis ; therapy ; Uterine Hemorrhage ; diagnosis ; etiology ; therapy ; Vaginal Diseases ; diagnosis ; etiology ; therapy

Macrovascular complications are the main death or disabling causes of diabetic patients.In recent years,the results of a number of clinical trials aimed at preventing diabetic macrovascular complications have been unveiled.Comprehensive and systemic analysis of these results may give great enlightenment to the clinicans,as well as promote the work in preventing diabetic macroangiopathy in China.

ObjectiveTo investigate the feasibility,safety and efficacy of tracheal extubation with directly connected negative pressure suction. Methods86 patients with Ⅰ or Ⅱ degree of ASA,aged 18～65 years old,without history of respiratory disease,difficult airway and ventilation problems were involved in this study.All patients undergoing endotracheal general anesthesia were randomly divided into group A and B with 43 cases in each group.Group A used negative pressure directly connected to external side of the endotracheal tube before extubation.Group B used suction tube putting into the endotracheal tube before extubation.MAP,HR,ECG,SpO2,the condition of cough and expectoration and complicatons after extubation were recorded. ResultsIn group A the MAP,HR slightly increased,SpO2 slightly decreased,ECG showed no significant change,but the differences were not significant.In group B,MAP,HR,SpO2 showed significant difference compared with those before extubation and the corresponding period of group A. ConclusionsThe method that connecting negative pressure suction with endotracheal tube can effectively reduce the cardiovascular response during extubation,It also can avoid hypoxia,reduce the tracheobronchial injury and pulmonary complications.It's a practical good method in tracheal extubation.

Objective To establish an IC method for determination of iodate, bromate, nitrite in cosmetics, food and salt by suppressed anion-exchange chromatography and ion-exchange with the addition of post column reagent. Methods A high capacity anion exchange column, Ion Pac9-HC column was used by 9 mmol/L sodium carbonate as eluent, and the flow rate was set up at 1.3 ml/min,an auto-suppression external water mode was used, 0.5 g/L o-dianisidine. 2HCl(ODA)+5 g/L KBr+20%methanel+5.6% nitric acid was used as post column reagent , the flow was set up 0.7 ml/min. The post column reaction (PCR) temperature was 60 ℃ and the visible absorbance detection at 450 nm. Samples were pretreated and analysed. Results The influence of pH of samples and coexist anion on determination was discussed. The detection limit(MDL) of the present method was 0.008-0.10 mg/kg, the recovery rates of the method were 92.0%-109.0% and the relative standard deviation (RSD) were 0.1%-7.2%. Conclusion This method is accurate, sensitive and suitable for trace analysis (?g/kg) of cosmetics and foods samples.

Objective To estimate the marginal value of the chemical oxygen demand (COD) in drinking water by evaluation of uncertainty. Methods According to Evaluation and Expression of Uncertainty in Measurement (JJF1059-1999), analysis of measure uncertainty of the chemical oxygen demand determined by acidic potassium permanganate titrate prescribed in Sanitary Standards for Drinking Water (2001) was conducted. Results The type A relative standard uncertainty was 0.584%, type B was 0.781%, in which the sub-item uncertainty led by using 25 ml burette was 0.708%, the water sample volume was 0.056%, the adjusted potassium permanganate standard solution was 0.325%; the relative combined standard uncertainty was 0.975%, the expanded uncertainty was 1.95%. Conclusion According to the result of the uncertainty (3.08?0.06) mg/L, COD in the polluted sample exceeds the limit, the use of 25 ml burette produced the most contribution to the uncertainty.