Aim To study the effect of bombesin on body temperature thermothreshold.Methods With IL-1?-induced febrile rats as research subject,the content of PGE2 in hypothalamus and plasma was detected with radioimmunoassay.Results(1) Induced by i.c.v.injection of IL-1?(0.1 ?g),the content of PGE2 in hypothalamus and plasma of the febrile rats significantly increased(P