1.Research on the evaluation of salivary gland function
Chinese Journal of Nuclear Medicine and Molecular Imaging 2013;(3):235-237
Assessment of salivary gland function plays an important role in the diagnosis and treatment of salivary gland disease.Currently,there are several ways to evaluate the salivary gland function including sialography,salivary gland flowmetry,radionuclide imaging,ultrasonography Doppler and MRI.The pros and cons of these different methods were reviewed and analysed.Nowadays,sialography and salivary gland flowmetry are less commonly used clinically.Doppler can be used for screening of salivary gland diseases.Radionuclide imaging is the clinically preferred method,and MRI is one of the most rapidly developing methods for the evaluation of salivary gland function.Proper selection of these methods can provide valuable information for the diagnosis and treatment of salivary gland diseases.
2.Combination of multiple CT signs in diagnosis of nodular goiters
Miaoping ZHU ; Yanyan SHU ; Zhijiang HAN
Chinese Journal of General Practitioners 2016;15(4):281-285
Objective To investigate the combination of multiple CT signs in diagnosis and differential diagnosis of nodular goiters (NGs).Methods The CT images of 242 pathologically confirmed lesions (> 10 mm in diameter) from 188 patients with nodular goiters were retrospectively reviewed.The CT signs,including regular shape,cystic degeneration,clearer enhancement margin,strong enhancement of nodular goiters were compared with those of 236 pathologically confirmed lesions (> 10 mm in diameter)from 225 patients with papillary thyroid carcinomas (PTCs).The sensitivity,specificity and accuracy of different CT signs or their combination in diagnosis and differential diagnosis of NGs were analyzed.Results Regular shape was present in 208 of 242 NGs (86.0%) and in 35 of 236 PTCs (14.8%) (x2 =241.804,P =0.000).Cystic degeneration was present in 143 of 242 NGs (59.1%) and 7 of 236 PTCs (3.0%)(x2 =174.783,P =0.000).Clearer enhancement margin was present in 192 of 242 NGs (79.3 %) and in 51 of 236 PTCs (21.6%) (x2 =159.318,P =0.000).Strong enhancement was present in 41 of 242 NGs(16.9%) and in 3 of 236 PTCs (1.3%) (x2 =35.108,P =0.000).Regular shape showed the highest sensitivity and accuracy for diagnosis of NGs (86.0% and 85.6%),while strong enhancement showed the highest specificity (98.7%).The combination of regular shape and clearer enhancement margin showed the highest sensitivity and accuracy of 67.4% and 80.5%,respectively.The combination of strong enhancement with any of other signs showed the highest specificity of 100.0%.The combination of regular shape,cystic degeneration and clearer enhancement margin showed the highest sensitivity,specificity and accuracy of 45.5%,99.6% and 72.2% respectively.The combing of 4 signs showed a sensitivity,specificity,and accuracy of 2.9%,100.0% and 50.8%.Conclusion CT scan is effective for diagnosis of NGs,and the combination of different CT signs can significantly improve the specificity and reduce the incidence of misdiagnosis to avoid unnecessary surgery.
3.A phenomenological research on the mental journey of parents of children with leukemia
Zhuo LIU ; Yanyan ZHU ; Xiaohan LI
Chinese Journal of Practical Nursing 2014;30(9):41-45
Objective To explore the psychological experience and the needs of parents who had children with leukemia in order to provide the theoretical and practice reference for clinical nursing work.Methods A qualitative phenomenological methodology was used in this study.10 parents of children with leukemia were interviewed with semi-open-ended questions.The NVivo10.0 software was used to supervise,excavate and seek data.The Colaizzi phenomenological methodology was used to analyze the data.Results Through careful analysis,four themes were identified:leukemia news was like crowning calamity; psychological changes generally varied in different stages; pressure had pluralism as well as the diversity of coping.The demand had multipolarity.Conclusions Attention should be paid closely to parents with leukemia children.The individualized measures should be taken by medical workers in order to provide them with mental nursing and holistic nursing and make them stay in a best health state,so that they can supply better social support for these children.
4.Exploration of azithromycin on secondary prevention of asthma
Yanyan YU ; Jixian LIU ; Hong ZHU
International Journal of Pediatrics 2009;36(3):222-225
Objective To discuss the effect of azithromycin on the airway inflammation in children at high risk for asthma by detecting the serum concentration change of eosinophil cationic protein(ECP), intedeukin-8(IL-8) and nitrogen oxide(NO), and also to explore the effect of azithromycin on secondary prevention of asthma. Methods Two hundred and twenty three cases of primary asthmatic attack with atopy (eczema, family asthmatic history) were collected and divided into four groups(group A, B,C,D) after asthmatic symptoms relief, group A was taken orally with azithromycin(5mg/kg Biw), group B was inhaled budesonide(0.5mg Bid), group C was taken orally with singulair (4mg qN),and group D was only given with symptomatic treatment. The vein blood was sampled on the first day in hospital, before and after medication respectively when treatment of three months was completed. Serum concentration of ECP and IL-8 was obtained by ELISA methods, and NO was measured by nitric acid enzyme reduction method. Clinic service and telephone follow-up was taken for one year. Results After three monthes intervention, there was significant difference in the serum concentration of ECP, IL-8 and NO at group A, B, C compared with group D( P<0.01 ). There was no significant difference in decrease of ECP and NO between group A and B( P > 0.05), but decrease of ECP and NO in group C was significant difference compared with group A( P<0.01). The serum concentration of IL-8 in each group was obviously decreased especially in group A, and difference was obvious between group A and group B,C( P<0.01). There was no significant difference in the cases of asthma recurrence within three months and asthmatic recurrence within one year between group A and group B, group C and group D respectively. Conchlsions (1)The medication of azithromycin might result to decrease the serum concentration of ECP and NO, especially for IL-8 in children at high risk for asthma. (2)The effects of azithromycin on change of ECP and NO in children at high risk for asthma were similar to budesonide, but different with montelukast, while the inhabitant effects of IL-8 were different with inhaled steroid hormone and leukotriene receptor obviously. (3)There was some valid contribution of azithromycin actting on the secondary prevention of asthma in our investigation.
5.Application of contrast-enhanced ultrasound in the diagnosis of vascular complications of renal transplantations
Jianping ZHU ; Yanyan JIANG ; Junfeng HONG
Chinese Journal of Ultrasonography 2008;17(5):413-415
Objective To evaluate contrast-enhanced ultrasound(CEUS) in the diagnosis of vascular complications of transplanted kidneys.Methods Twelve patients with vascular abnormalities after renal transplantation were observed and analyzed using CEUS, and the diagnosis of all cases was confirmed by means of operation,pathology or angiography.Results Five patients with renal artery stenosis,2 patients with renal artery thrombosis,3 patients with pseudoaneurysm, 1 patient with pseudophlebangioma, and 1 patient with intrarenal extensive microthrombus were found.The coincidence of CEUS was 100%.Conclusions CEUS is a new method with the characteristics of non-nephrotoxic damage to kidney and comparable with angiography in terms of dynamic imaging.
6.Efficacy of Ultrasound-guided Channel Establishment in Minimally Invasive Percutaneous Nephrolithotomy
Yanyan JIANG ; Jianping ZHU ; Feifei HU
Chinese Journal of Minimally Invasive Surgery 2001;0(02):-
Objective To evaluate the value of ultrasound-guided channel establishment in minimally invasive percutaneous nephrolithotomy(MPCNL).MethodsBetween May 2006 and December 2007,85 patients received MPCNL in our hospital.Puncture points were selected and then channels were established under the guidance of ultrasonography according to the distributions of calculi during MPCNL.ResultsUnder the guidance of ultrasonography the puncture was completed at one session in all of our 85 cases.No massive hemorrhage or other severe complications occurred.In the cases,57 cases were cured after the first operation,and 27 cases received a second surgery.One of the cases was diagnosed as having calcification of the renal papillae without kidney calculi during the operation.Residual calculi(
7.Changes and significance of insulin-like growth factor-1 in infant myocarditis
Yanyan LIANG ; Hua ZHU ; Shaofei YU
Chinese Journal of Primary Medicine and Pharmacy 2014;(22):3371-3372,3373
Objective To investigate insulin-like growth factor-1(IGF-1) on the protective effect of infant myocarditis.Methods The serum levels of IGF-1 was detected by two-site enzyme-linked immunosorbent assy ( ELISA) and CK-MB by electrochemiluminescence at the acute and convalescent in 50 infant with myocarditis,and 50 normal healthy children as the controls.Results The serum levels of IGF-1 in acute myocarditis was significantly lower than those of healthy children and the convalescen[(22.90 ±9.30) mg/L vs (45.69 ±10.95) mg/L, (38.99 ±9.06)mg/L,all P<0.01],while the CK-MB was significantly higher than those of the control group and the convalescent[(77.48 ±8.71)mg/L vs (14.99 ±7.62)mg/L,(17.99 ±6.31)mg/L,all P<0.01.IGF-1 and CK-MB was negative correlation (r=-0.62,P<0.01).Conclusion IGF-1 is involved in the repair process of myocardial injury in myocarditis infant,and play some protective role in the mechanism.
8.Changes of Electroencephalogram in Post-stroke Hemiplegia Patients Treated with Electroacupuncture at the Nerve Trunk
Yongzhi ZHU ; Yi CHEN ; Yanyan ZHANG ; Xuejun CUI
Journal of Acupuncture and Tuina Science 2010;08(6):349-352
Objective: To observe the short-term effects of electroacupuncture at different acupoints on patients with hemiplegia after cerebral infarction. Methods: Patients with cerebral infarction were randomly allocated into a group of electroacupuncture nerve trunk and a group nerve trunk or routine acupoints, respectively, once a day, for 14 d. Results: Electroacupuncture at nerve trunk had better effects than at routine acupoints. The short-term improvement of electroencephalogram had significant differences (P<0.05). Conclusion: Electroacupuncture at the nerve trunk could improve the neurologic impairment and brain function, and it has a better result than routine electroacupuncture.
9.Study on the effect of the active phase of Doula delivery ball apparatus combined with correct occipitoposterior
Mo YANG ; Donghong WEI ; Yanyan WANG ; Xinqiang ZHU
Clinical Medicine of China 2016;32(1):89-91
Objective To investigate the effect of Doula delivery ball apparatus combined with correct occipitoposterior.Methods Four hundred primiparas whose dilatation of cervix of 3 cm and position of foetus was occipitopostenor position, were randomly divided into observation group and control group according their wishes, and each group of 200 cases.Doula delivery ball was used for the observation group,while the free body position, the traditional delivery mode was the control group.The vaginal delivery rate, degree of pain, postpartum 2 h bleeding volume and neonatal asphyxia rate were compared between the two groups.Results The degree of pain Ⅲ degree was 4.0% (8/200) ,lower than the control group(50.0% (100/200), x2 =11.55,P<0.01).The vaginal delivery rate in observation group was 84.5% (169/200), higher than that in control group (60.5% (121/200);x2 =28.905,P=0.001).Postpartum 2H bleeding was (156.3±53.2) ml, lower than the control group((268.1±54.6) ml, t =20.70, P<0.01).The Postpartum bleeding rate was 0.5% (1/200), lower than that in control group (4.0% (8/200) ,P =0.018).Conclusion Doula delivery ball is applied to the first active stage of labor can effectively relieve pain, promote the safety of natural childbirth.
10.Rivastigmine hydrogen tartrate on stroke patients with vascular dementia: study of magnetic resonance spectroscopy
Yanyan HUANG ; Xiaoyan WU ; Zhen ZHU ; Daoying GENG
Chinese Journal of Neurology 2000;0(05):-
Objectives To examine the clinical usefulness of magnetic resonance spectroscopy (MRS) on assessment of vascular dementia (VD) in patients with stroke; the relationships between metabolic changes of brain and clinical symptom improvements after giving rivastigmine in these patients.Methods 20 stroke patients without VD, male 17, female 3, with a mean age of (71.7?4.7) years old; 23 stroke patients with VD, male 20, female 3, a mean age of (72.9?5.1) years old; 20 normal volunteers were studied, a mean age of (70.9?4.8) years old. MRS was performed in all these patients. The patients with VD were prescribed rivastigmine hydrogen tartrate ("Exelon", Norvatis), and given MRS assessment half a year later.Results The patients with VD had a significantly lower N-acetyl aspartate/Creatine (NAA/Cr) ratio (mean?SD: left: 0.57?0.30; right: 0.66?0.29) and higher Choline/Creatine (Cho/Cr) ratio (mean?SD: left: 1.79?0.52; right: 1.97?0.44) in bilateral temporal hippocampus area, compared to those without VD (mean?SD: NAA/Cr: left, 0.91?0.31; right, 0.87?0.27, P