1.DHS Combined with Hollow Traction Bolt Treat Thighbone Interrotor Fracture
Yazhou GAO ; Yanxing GAO ; Kehong SUN ;
Journal of Zhejiang Chinese Medical University 2006;0(06):-
[Objective]To explore clinical effect of DHS combined with hollow traction bolt treating thighbone interrotor fracture. [Method]From May 2003 to July 2006,apply DHS combined with hollow traction holt to treat thighbone interrotor fracture 9 ca- ses,6 males,3 females,aged 47~72,62.6 in average,5 cases of left side,4 right side;classify under Evan's:5 cases of typeⅡ, 2 ofⅢ,2 ofⅣ.[Result]Follow up for 6~21 months,12 months in average.Appraise the clinical effect by Huang Gongyi's standard,7 cases were very good,1 good,1 bad,the good rate was 89%.[Conclusion]DHS combined with hollow traction bolt treating thighbone interrotor fracture can obviously increase stability of fracture point,reduce local rotation,helpful to fracture cure and early exercise,as well as the complication.
2.Application of Natural Ingredients of Traditional Chinese Medicine in Pain Management: A Review
Mingze TANG ; Zhen SHEN ; Tianle GAO ; Yanxing HAN ; Jiandong JIANG
Chinese Journal of Experimental Traditional Medical Formulae 2023;29(24):260-272
Pain is one of the most prevalent health problems. Current medications for pain are mainly anticonvulsants, tricyclic antidepressants, and opioidergic drugs. However, their therapeutic effectiveness is limited during application, and some even have severe side effects. In recent years, research on natural ingredients from Chinese herbal medicine has been extensively conducted for their analgesic activities. A series of natural ingredients represented by alkaloids, coumarins, flavonoids, and terpenoids have shown great analgesic activity, and further studies on their analgesic mechanism have found that most natural products have multi-target analgesic mechanisms. It can exert analgesic effects by blocking ion channels, regulating related receptors, or inducing anti-inflammatory or antioxidant effects. In addition, many traditional Chinese medicine (TCM) formulas have shown great analgesic ability after clinical application and have multiple complex analgesic mechanisms. The drug cloud (dCloud) theory can better describe the mechanisms, and it can represent the complete therapeutic spectrum of multi-target analgesics from two dimensions, namely the "direct efficacy" that directly inhibits pain signals and the "background efficacy" that targets the root causes of pain. The authors summarized the research progress of natural ingredients with analgesic effects found in Chinese herbal medicine so far, as well as the analgesic efficacy and potential mechanisms of TCM formulas with great analgesic effects in clinical applications, so as to provide a new basis for searching for new analgesic drugs from TCM.