1.Design and Application of Vocational Competency Assessment System
Yunyang XU ; Ji ZHANG ; Yanwen XU
Journal of Medical Informatics 2017;38(2):43-47
Based on the characteristics that most patients in Vocational Rehabilitation Department of Guangdong Provincial Work Injury Rehabilitation Hospital are patients with occupational injuries,the paper analyzes the hospitalized business process,concretely introduces the main functional modules,design framework,safety requirements,database design,etc.of the vocational competency assessment system.The application of this system provides references for rehabilitation doctors and vocational rehabilitation therapists to make training schemes,strengthens patient information management,improves working efficiency and service level.
2.The first-aid treatment and nursing of six Adams-Stokes syndrome children
Xiumin SHAO ; Yanwen JI ; Ming LIU
Chinese Journal of Postgraduates of Medicine 2015;38(z1):100-102
Objective To explore the first-aid treatments and nursing measures of children with Adams-Stokes syndrome.Methods Totally 6 data of patients with Adams-Stokes syndrome who was successfully rescued were analyzed and discussed.Results The main cause of Adams-Stokes syndrome were Severe ventricular tachycardia.The third degree atrioventricular block,Severe myocarditis,Dilated cardiomyopathy,the common inducing factors of Adams-Stokes syndrome were Hypokalemia,psychological factors,overeating,constipation.Conclusion The premise of the successful rescue on Adams-Stokes syndrome children are regulated observation、knowing the patient' s condition well,the medicine and goods for first-aid treatment all ready,and timely finding,correct estimate,giving emergency treatments timely,appropriate nursing are the keys of its successful rescue.
3.T CELL IMMUNE RESPONSE TO THE CIRCUMSPOROZOITE PROTEINOF PLASMODIUM FALCIPARUM, SOUTHERN CHINA ISOLATE FCC/HN AND ANTIGEN-INDUCED HL-2 AND IFN-γ Production ANALYSIS OF SPECIFIC
Zheng FANG ; Yanwen LIU ; Weiqun HUANG ; Xin JI ; Yukun SHI ; Xinbing YU
Chinese Journal of Zoonoses 2000;(2):32-34
Inthis study, the DNA fragment encoding the regions Ⅰ to Ⅱ of CSP gene from Plasmodium falciparm isolate FCC1/HN was cloned into an. expression vector pcDNA3 contained cytomegalovius (CMV) and transformed into human Hela cell line. The expressed protein PfCSP (condidate vaccine) was used to immunize BALB/c mice by subcutaneous、 intravenous or intraperitoneal administration respectively. The splenocyte of BALB/c mice immumized with the condidate vaccine released significantly IL-2 and IFN-γ following stimulation with this vaccine. It is associated with increase of the splenic T lymphocyte proliferation stimulated by this vaccine and enhancement of NK cell killing activity in the former studies. These results suggested that the vaccine could stimulate T cell response and enhance the cell-mediated immunity.
4.Screening of pancreatic lipase and alpha-glucosidase inhibitors from Chinese dietary herbs.
Xiaoli SUN ; Kaibin ZHANG ; Xiuhong JI ; Yanwen WANG ; Zidichouski JEFFREY ; Yan TONG ; Huimin GAO ; Junzeng ZHANG ; Zhimin WANG
China Journal of Chinese Materia Medica 2012;37(9):1319-1323
The present study was conducted to develop new inhibitors of pancreatic lipase and alpha-glucosidase from Chinese dietary herbs. Sixty-three dietary herbs from 39 taxonomic families were selected and extracted with aqueous ethanol or water. The extracts were then tested with in vitro enzyme assays for their ability to inhibit pancreatic lipase and alpha-glucosidase activities. Orlistat and acarbose were used as two positive controls. The extracts of Nelumbo nucifera, Curcuma longa, Piper longum and Morus alba showed strong pancreatic lipase inhibitory effects with IC50 at (28.00 +/- 5.51), (5.24 +/- 0.51), (14.76 +/- 2.58), (4.78 +/- 0.58), (3.41 +/- 0.67) mg x L(-1), respectively. These extracts also showed potent alpha-glucosidase inhibitory activities with IC50 at (1.98 +/- 0.13), (0. 18 + 0.007), (0.71 +/- 0.08), (0.077 +/- 0.005), (0.089 +/- 0.006) g x L(-1), respectively. The results provide useful information for developing new drugs or natural health products for hyperlipidemia and hypoglycemia from Chinese dietary herbs.
Curcuma
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chemistry
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Drugs, Chinese Herbal
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chemistry
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pharmacology
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Enzyme Inhibitors
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chemistry
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pharmacology
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Lipase
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antagonists & inhibitors
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Morus
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chemistry
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Nelumbo
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chemistry
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Pancreas
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enzymology
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Piper
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chemistry
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Plant Extracts
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chemistry
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pharmacology
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alpha-Glucosidases
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metabolism