This article described the background,concept,characteristic and objective of the research-based nursing,systematically introducing the main measures including management mechanism, nursing service,nursing staff training,and nursing scientific development.Other areas covered include innovation management mechanism,updating service philosophy,improving nursing staff training,and constructing scientific research platform.

Objective To find the body maximum scope of activities on patients with PICC catheter,in order to do better health education for patients after catheterization mission.Methods We chose 75 patients who accepted the catheter at right limb for the first time,with the location of the catheter tip in the superior vena cava lower 1/3,superior vena cava and right atrium in 3-4 cm.We defined arms natural prolapse as the 0 position,which was the controlled position.Position 1 referred to the fingers touching the back to the highest,position 2 as shoulder joint rear protraction to the biggest angle,position 3 as shoulder joint anteflexion to the biggest angle,position 4 as shoulder joint adduction to the biggest angle.After the 4 kinds of position,X-ray was taken,the highest level in the subclavian vein pipe as the zero line,computer software was used to measure the each asana PICC tip from zero distance.Results Tips of PICC catheters moved up when taking position 1 and 2,whereas tips moved down when taking position 3 and 4.Position 1,2,3 and 4 moved (-26.18 ±11.32),(-16.09 ± 10.97),(24.36 ± 19.05),(36.64 ± 22.48) mm respectively compared with the controlled position(P ＜ 0.01).Conclusions According to 4 kinds of position which induced the PICC tip changes to guide the patients daily actions could ensure the quality of life of patients with PICC and the use value of catheter.

Objective To explore the characteristics and nursing measures of functional delayed gastric emptying ( FDGE) after pancreatic operation .Methods The reasons were analyzed in ten patients with FDGE after pancreas head carcinoma operation , and the time and the characteristics of FDGE were summarized . Results The average time of the occurrence of FDGE in ten patients was ( 6.2 ±3.1 ) d after stopping gastrointestinal decompression , and 8 cases of FDGE occurred in (4.3 ±2.3) d after taking liquid diet .During the period of FDGE , the lowest amount of the gastrointestinal decompression drainage was 146 ml, and the highest was 1 540 ml, and the average was (578 ±446)ml, and the average amount of the drainage was (176 ± 168 ) ml one day before the removal of gastric tube .All patients were recovery and discharged from the hospital . Conclusions The proper diet guidance especially 3 to 5 days after taking liquid diet , observation of the eating , scientific nutritional support , closely observation of gastrointestinal decompression drainage , early detection and early treatment and so on are the key points to promote the early recovery of the patients with FDGE .

Objective:To explore the scientific and feasible plan of early ambulation after pancreaticoduodenectomy.Methods:A research group was established in February 2020, and a plan for early ambulation was initially formulated according to evidence-based literature and expert group discussions. From June to October 2020, a total of 11 experts from three Class Ⅲ Grade A hospitals in Beijing were selected for two rounds of consultation by using the Delphi method. By calculating the expert positive coefficient, expert authority coefficient, and the Kendall coordination coefficient, an early ambulation plan was constructed according to the expert's revised opinions.Results:Among two rounds of expert consultation, and the questionnaire recovery rates were all 100.00%, and the expert authority coefficient was 0.92, and the Kendall coordination coefficient were 0.337 and 0.257, respectively. The finalized early ambulation plan after pancreaticoduodenectomy included two parts, namely, the early safe ambulation evaluation standard and the early ambulation program, with a total of 14 first-level indicators and 36 second-level indicators.Conclusions:The early ambulation plan after pancreaticoduodenectomy is scientific and feasible, and can be further tested and applied in clinical practice.

Objective:To explore the incidence of thirst in patients undergoing pancreaticoduodenectomy and analyze its influencing factors.Methods:From March to October 2022, 155 patients with pancreaticoduodenectomy admitted to the First Medical Center of the Chinese People's Liberation Army General Hospital were selected as the study subject by convenience sampling. The patients were surveyed using the self-made general information questionnaire, Thirst Numerical Rate Scale, oral mucosal misture score, Self-Rating Anxiety Scale, and Self-Rating Depression Scale to understand the incidence of thirst and analyze influencing factors.Results:A total of 153 valid questionnaires were collected, with a valid response rate of 98.71%. Among them, 124 patients (81.05%) experienced postoperative thirst. Univariate analysis showed that there were statistical differences in the incidence of thirst among patients with different ages, fasting time, smoking history, drinking history, hypertension history, diabetes history, anxiety and depression ( P<0.05). Logistic regression analysis showed that age, hypertension history, diabetes history, anxiety and depression were the main influencing factors for thirst in patients undergoing pancreaticoduodenectomy ( P<0.05) . Conclusions:Thirst is common in patients after pancreaticoduodenectomy. Age, hypertension history, diabetes history, anxiety and depression are the influencing factors of thirst in patients after pancreaticoduodenectomy. Medical and nursing staff should provide targeted interventions for thirst prevention and treatment based on relevant factors.

Objective:To explore the relationship between anxiety, depression and various dimensions of cognitive function in patients with mild cognitive impairment (MCI) .Methods:The convenient sampling method was adopted to conduct memory screening for 727 elderly people who visited the multidisciplinary joint memory clinic of a Class Ⅲ Grade A hospital in Beijing from January to December 2019. With their consent, 247 MCI patients were investigated using Montreal Cognitive Assessment (MoCA) , Generalized Anxiety Disorder (GAD-7) and Patient Health Questionnaire (PHQ-9) .Results:A total of 247 questionnaires were distributed and 233 valid questionnaires were returned. There were 67 cases (28.8%) of MCI patients with anxiety and depression, 11 cases (4.7%) with anxiety, 53 cases (22.7%) with depression and 102 cases (43.8%) without anxiety and depression. In MCI patients, anxiety was positively correlated with delayed recall ( P<0.05) , while depression was negatively correlated with language function ( P<0.05) . MCI patients with different emotional states had statistically significant differences in language function ( P<0.05) . Conclusions:MCI patients have a higher incidence of anxiety and depression, and anxiety and depression will affect different dimensions of cognitive function in MCI patients. Medical staff need to provide targeted interventions for MCI patients with different emotional characteristics.

NDFIP1 has been previously reported as a tumor suppressor in multiple solid tumors, but the function of NDFIP1 in NSCLC and the underlying mechanism are still unknown. Besides, the WW domain containing proteins can be recognized by NDFIP1, resulted in the loading of the target proteins into exosomes. However, whether WW domain-containing transcription regulator 1 (WWTR1, also known as TAZ) can be packaged into exosomes by NDFIP1 and if so, whether the release of this oncogenic protein via exosomes has an effect on tumor development has not been investigated to any extent. Here, we first found that NDFIP1 was low expressed in NSCLC samples and cell lines, which is associated with shorter OS. Then, we confirmed the interaction between TAZ and NDFIP1, and the existence of TAZ in exosomes, which requires NDFIP1. Critically, knockout of NDFIP1 led to TAZ accumulation with no change in its mRNA level and degradation rate. And the cellular TAZ level could be altered by exosome secretion. Furthermore, NDFIP1 inhibited proliferation in vitro and in vivo, and silencing TAZ eliminated the increase of proliferation caused by NDFIP1 knockout. Moreover, TAZ was negatively correlated with NDFIP1 in subcutaneous xenograft model and clinical samples, and the serum exosomal TAZ level was lower in NSCLC patients. In summary, our data uncover a new tumor suppressor, NDFIP1 in NSCLC, and a new exosome-related regulatory mechanism of TAZ.
Humans ; Carcinoma, Non-Small-Cell Lung/metabolism* ; Carrier Proteins/metabolism* ; Cell Line ; Cell Proliferation ; Exosomes/metabolism* ; Lung Neoplasms/genetics* ; Membrane Proteins/metabolism* ; Transcriptional Coactivator with PDZ-Binding Motif Proteins/metabolism*