Objective To explore the relationship of TCM syndromes in chronic heart failure (CHF) with left ventricular mass index (LVMI) and left ventricular ejection fraction (LVEF). Methods Two hundred and ninety-six CHF patients were classified into the syndromes of Qi deficiency (21 patients), Qi deficiency and blood stasis (98), fluid retention due to Qi deficiency and blood stasis (72), blood stasis due to the deficiency of Qi and yang (56), and blood stasis and fluid retention due to the deficiency of Qi and yang (49). LVMI and LVEF in different syndromes were campared.Results LVMI presented an increasing sequence and LVEF presented a decreasing sequence in the syndromes of Qi deficiency, Qi deficiency and blood stasis, fluid retention due to Qi deficiency and blood stasis, blood stasis due to the deficiency of Qi and yang, and blood stasis and fluid retention due to the deficiency of Qi and yang. Between the syndromes of Qi deficiency, Qi deficiency and blood stasis, and fluid retention due to Qi deficiency and blood stasis, there were significant differences of LVMI and LVEF (P0.05), but LVMI and LVEF in these two syndromes differed from those in the former three syndromes (P

[Objective] To study the pharrnacodynamic effect of Bao Xin Kang on animal models with cardiac insufficiency (CI) . [Methods] CI animal models were established by constricting the abdominal aortae in rabbits. The pathological results in different groups were compared. The hemodynamics indices such as LVEDP and?dp/dtmax and NO level were measured. [Results] Compared with the model group, the high dose of Bao Xin Kang can lessen the hyperplasia and hypertrophy of the myocardium and relieve the pulmonary edema in animals and improve the hemodynamics indices. LVEDP was decreased ( P

Objective To study the variation of the level of lipids, OX-LDL and vascular intimal injury in diet-induced hyperlipidemic and chronic Cpn-infected mice and the interventional functions of berberine. Methods C57BL/6J mice were divided randomly into 6 groups: Berl group, Ber2 group, azithromycin group, atorvastain group, cholesterol + Cpn group, and normal group. Mice were inoculated intranasally with Cpn for three times, every 2 weeks over a 6-week period and feeding with high cholesterol diet. Berl group was administrated with berberine at the beginning of CPn infecting, while ber2 group, azithromycin group and atorvastain group were administrated with the drug after the 3rd CPn infecting. The serum index, HE dye of the aortas and electron microscopic examination were observed. Results Lipids disorder, increased level of OX-LDL and vascular intimal injury were found. The level ofTC, LDL, TG OX-LDL in Bet group, azithromycin group, and atorvastain group declined in different extent. Conclusion Berberine has effects of regulating lipids disorder, OX-LDL and protecting vascular intima of diet-induced hyperlipidemic and chronic Cpn-infected mice.

Objective To study the effect of heat-clearing and detoxicating remedy on the Level of Serum Hs-CRP, WBC and homocysteine in patients with Atherosclerosis. Methods 50 patients were be selected and randomly divided into a treatment group and a control group. The treated group was treated with SanHuang pill for 2 weeks in addition to the basal treatment of western medicine, and the control group was treated with western medicine. The level of serum hs-CRP, WBC and homocysteinemia were observed. Results The level of serum Hs-CRP, WBC and homocysteinemia declined in different extent after treated by SanHuang pill, the treated group showed a better result than the control group. Conclusions Heat-clearing and detoxicating remedy can reduce the level of serum Hs-CRP and homocysteine.

Objective To explore the relationship of apolipoprotein E(ApoE) and its gene polymorphism with phlegm and blood stasis syndrome in patients with coronary heart disease(CHD).Methods Ninety-seven qualified CHD patients involving phlegm syndrome(PS),blood-stasis syndrome(BSS),and phlegm and blood stasis syndrome(PBSS) were adopted.Thirty-five healthy volunteers were enrolled into the control group.Serum ApoE level was examined in all of the subjects,and their whole blood DNA were extracted for the detection of ApoE gene polymorphism by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Correlation analysis of the data was performed with SPSS11.0 software.Results The difference of diabetes mellitus,smoking,low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C) was significant between CHD patients and healthy volunteers(P

[Objective] To observe the preventive effect and mechanism of heat-clearing and toxicity-removing therapy for the treatment of acute coronary syndrome (ACS), and to explore the relationship of ACS with inflammation. [Methods] Fifty five ACS patients were randomized into 2 groups:41 patients in group A were treated with Sanhuang Tablets (mainly composed of Radix et Rhizoma Rhei, Radix Scutellariae and Rhizoma Coptidis) p.o., 4 tablets one time, twice a day, and a routine treatment for anticoagulation, anti-platelet aggregation and anti-myocardial ischemia; 14 patients in group B were given routine treatment for anticoagulation, anti-platelet aggregation and anti-myocardial ischemia. The treatment course lasted 2 weeks. After treatment, improvement in symptoms such as chest pain, chest distension, short breath, palpitation, fever, spontaneous sweating, insomnia, lassitude, aversion to cold and cold limbs was compared between group A and group B by scoring method. Meanwhile, inflammatory indicators in the two groups were also observed before and after treatment. [Results] The decrease in symptom scores, as well as the decrease in blood C-reactive protein (CRP) , tumor necrosis factor a (TNF-?) and interleukin 6 (IL-6) , was obvious in group A than that in group B (P

Objective To assess the effect of sodium hyaluromate (HA) on degenerative disorders of the knee joint (KJ). Methods A prospective randomized controlled clinical trial was conducted. The experimental group received injections in the compartments of the involved KJ with 1% HA 20mg, whereas the control group received prednisolone (PS) of 75mg once a week with five injections as one course. One week before and after the treatment , clinical symptoms, amount of interleukin-6 (IL-6) and total protein of synovial fluid were measured and compared. Results Both drugs could relieve the clinical symptoms of KJ degenerative disorders. In HA group, marked improvement rate was 52.78% and failure rate was 2.86%, whereas marked improvement rate was 39.29% and failure rate 17.86% in PS group. The declined levels of IL-6 in synovial fluid were notably greater in HA group than those in PS group. Conclusion Intra-articular injection of HA is effective and safe in treating KJ dgenerative disorders with mild adverse reactions.

ive] To observe the therapeutic effect of Naoxing Granule (NG) for acute ischemic stroke (AIS) and to explore its mechanism. [Methods] Single-blind controlled trial was applied. Two hundred cases of AIS were randomly allocated to Group A (n = 150, treated with NG) and Group B (n = 50, treated with nimodipine). Therapeutic effect of NG was observed and plasma free radical levels and the ratio of thromboxane A2 (TXA2) and prostaglandin 2 (PGI2) were detected. [Results] The total effective rate was 91.3%and 76.0% , and the remarkably effective rate was 62.0% and 46.0% in Group A and Group B respectively ( P

To investigate the effects of Bushen Yixin Tablet (BYT) on plasma lipid peroxide (LPO) and sexual hormone in renal hypertension rats. Goldblatt's renal hypertension rat models were established. All rats were allocated to six groups: BYT groups (with high, moderate and low dosage of BYT respectively), captopril group, normal saline (NS) group and mimic-operation group. The treatment course lasted 4 weeks. Blood pressure was lowered in BYT groups (P

[Objective] To observe levels of plasma endothelin (ET) and calcitonin gene - related peptide (CGRP) in rats with myocardial hypertrophic heart failure affected by Yang Xin Kang (composed of Radix Ginseng, Radix Ophio-pogonis, Radix flicis Pubescetis, etc.) and its mechanism. [Methods] Rat models with myocardial hypertrophic heart failure was established by subcutaneous injection of isoprenaline for 13 days. Fifty rats were allocated to five groups: normal control (Group A), model (Group B), digoxin (Group C), high dosage of Yang Xin Kang (Group D) and low dosage of Yang Xin Kang (Group E). ET and CGRP levels were measured by radioimmunoassay method. [Results] ET level in Group B was higher and CGRP level lower than those in Group A (P