Objective To evaluate diagnostic methods and long-term curative effects for recurrent urethral stricture with false passage. Methods Among a total of 620 cases of urethral stricture or atresia treated from March 1987 to March 2005 in this hospital,false passage was present in 40 cases(6.4%).Diagnostic methods included urethrography,sonourethrography,injection of methylene blue into the bladder by cystostomy,CT and/or MRI examinations,or exploration by vesicotomy.Surgical methods included insertion of a memory metallic stent after urethrotomy in 10 cases,electrotomy in 7 cases,urethral reunion in 4 cases,hydroelectric shock wave therapy in 8,posterior pull-through urethroplasty in 4,patient self-administered urethral dilation in 5,excision of false passage in 1,and perineourethrostomy in 1.Results All the 40 cases were followed for 1~15 years(mean,9 years).The urethral stricture was cured in 32 cases(80.0%),and therapeutic failure was observed in 8 cases(20.0%),including 4 cases of unstable pelvic fracture.Conclusions Sonourethrography is the most accurate noninvasive method of staging urethra strictures.It is simple to perform,requires no radiation,and offers a dynamic three dimensional measurement.

[Summary] With the improvement of current medical diagnosis and treatment technology, more and more patients with adrenal hypoplasia congenita and hypogonadotropic hypogonadism have been diagnosed. DAX-1 gene mutation has been accounted for one of the most important reasons. Clinical manifestations include adrenocortical hypofunction such as loss of salt, dehydration, nausea and vomiting, as well as gonad dysplasia of male patients in puberty. The disease can be diagnosed by blood biochemical and hormonal level testings, imaging tests and gene sequencing. Patients can be treated by glucocorticoid, mineralocorticoid, and male sex hormone. The review will expand the diagnosis and treatment of adrenal hypoplasia congenita with hypogonadotropic hypogonadism caused by DAX-1 gene mutation.