1.Microembolic signals and adhesion molecules in patients with cerebral ischemia
International Journal of Cerebrovascular Diseases 2010;18(7):527-531
Unstable plaque is one of the major sources of microemboli.The microembolic signals indicate that the patients had unstable plaques and are prone to cerebral infarction recently.A series of adhesion molecules involved in the regulation of inflammatory response and functional changes of cerebral microcirculation during ischemic brain injury.The interaction among the adhesion molecules is conducive to leukocyte adhesion,migration,and platelet aggregation,thereby promoting inflammatory response and thrombosis.Recent studies have indicated that adhesion molecules are closely correlated with the instability of atherosclerotic plaques,which may have involved in the formation process of microemboli.The further study of adhesion molecules and microemboli contributes to implementation of drug intervention.It has a positive significance for the prevention and treatment of cerebral ischemia.
2.Microembolic signal monitoring in patients with symptomatic carotid artery stenosis
Shuai YI ; Xudong PAN ; Aijun MA ; Yanling SUI ; Kun WANG
International Journal of Cerebrovascular Diseases 2010;18(6):407-410
Objective To investigate the relationship of microembolic signals (MESs) between the degree of symptomatic carotid artery stenosis, ultrasonic characteristics of plaques, peak systolic velocity at the stenotic site and risk factors for stroke. Methods A total of 52 patients with symptomatic carotid artery stenosis were enrolled. MESs of bilateral middle cerebral arteries were monitored and detected by carotid color Doppler flow imaging. Results The positive rate of MESs on the symptomatic sides was significantly higher than that on the asymptomatic sides (28. 8% vs. 4. 5%, P < 0. 05). The positive rate was not significantly correlated with the degree of stenosis, ultrasonic characteristics of plaques, peak systolic velocity on the stenotic sides, and risk factors for stroke. Conclusions MESs mainly occurred on the symptomatic sides of carotid artery stenosis, and they were more closely correlated with unstable plaques.
3.Thermoplastic sheet in the improvement of positioning immobility technique for radiotherapy.
Yanling BAI ; Xiaohong SUI ; Chengji LIU ; Qiuping GAO ;
Chinese Journal of Radiation Oncology 1993;0(03):-
Objective To improve the set up accuracy for patients by MED TEC thermoplastic sheet. Methods First, a reference positioning line was scored on the supporting board of MEC TEC. Then, lines on the patient body were marked according to the reference positioning line. After fastening MED TEC thermoplastic sheet, CT top view imagines of patients who were immobilized with MED TEC thermoplastics sheet on the CT scanner were then drawn. The results by PC graphics software were analysed. Results A total of 57 cases was studied. Deviation in 52 (91.2%) cases was less than 3?mm. The cause of the with deviation exceeding 5?mm were all found.Conclusion Using the right method is very important. Thus, results with satisfactory deviations could be obtained when the set up are repeated.
4.Detection and clinical significance of vascular endothelium growth factor and microvessel density in patients with nasopharyngeal carcinoma.
Yanxin REN ; Jie YANG ; Yanling TU ; Jinpeng WU ; Jing MA ; Ruimei SUN ; Jun SUI ; Xiaojiang LI
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2012;26(19):900-903
OBJECTIVE:
To investigate the role of VEGF in angiogenesis of nasopharyngeal carcinoma tissue.
METHOD:
Serum and tissue VEGF were detected by the quantitative enzyme-linked immunosorbent assay (ELISA) method both in 62 nasopharyngeal carcinoma without therapy and 20 nasopharyngitis. The expression of microvessel density in tissue of nasopharyngeal carcinoma and nasopharyngitis were detected by immunohistochemical method.
RESULT:
(1) There was no significant relationship compared VEGF and MVD in nasopharyngeal carcinoma patient, gender and ages (P>0.05), while the expression of VEGF and MVD in later stage (III+IV) were significant higher than that in earlier stage (I+I) (P<0.01), and in positive lymph node group or metastasis group were higher than in negative group (P<0.01); (2) The expression of VEGF and MVD in nasopharyngeal carcinoma serum and tissue were higher than in nasopharyngitis (P<0.05); (3) There was positive correlation between VEGF and MVD in nasopharyngeal carcinoma tissue (r=0.865, P<0.01), but negative correlation in their serum (r=0.328, P>0.05).
CONCLUSION
VEGF could induce angiogenesis in nasopharyngeal carcinoma tissue, and play an important role in progression in nasopharyngeal carcinoma, VEGF could be an important marker for monitoring prognosis of disease.
Adolescent
;
Adult
;
Aged
;
Carcinoma
;
Endothelium, Vascular
;
metabolism
;
pathology
;
Female
;
Humans
;
Male
;
Microvessels
;
Middle Aged
;
Nasopharyngeal Carcinoma
;
Nasopharyngeal Neoplasms
;
blood supply
;
metabolism
;
pathology
;
Neoplasm Staging
;
Neovascularization, Pathologic
;
Prognosis
;
Vascular Endothelial Growth Factor A
;
metabolism
;
Young Adult