Objective To find out the changes of endothelial cell function and coagulation-fibrinolysis system in maintenance hemodialysis(MHD)patients with diabetic nephropathy(DN).Methods The plasma levels of TM,PAI-1,TAT and PAP in 28 DN-MHD,34 non-DN MHD and 40 controls were measured by ELISA.Results (1)The levels of TM,PAI-1,TAT and PAP in both DN group and non-DN group were significantly higher than those in control group,P

Objective To investigate the correlation between uric acid level and increase of carotid intima-media thickness (IMT) in the elderly.Methods Clinical data of elderly and middleaged people who took health physical examination from Jan.2013 to Dec.2014 in a 3A-level hospital in Beijing were collected.The elderly people were divided into IMT normal group and plaque group.Logistic regression and linear regression were used to analyze the related factors for IMT thickening and uric acid level.Results The occurrence rate of hyperuricemia had a significant difference between the elderly group and the middle-aged group (P＜0.01).There were significant differences in uric acid level [(350.6±89.6) μmol/L vs.(359.6±86.6) μmol/L, t=5.19, P＜0.05].Body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), blood urea,cholesterol, high density lipoprotein levels between the IMT normal group and plaque group were [(25.3±3.6)kg/m2 vs.(25.8±3.5) kg/m2, (115.9±13.8) mmHg vs.(126.8±16.9) mmHg, (74.6±11.3) mmHg vs.(77.8±12.1) mmHg, (4.9±0.9) mmol/L vs.(5.0±1.0) mmol/L,(1.2±0.3) mmol/L vs.(1.2±0.3) mmol/L, all P＜0.01].Multi factor correlation analysis showed that the IMT thickening was correlated with gender, SBP, low density lipoprotein, blood glucose,while had no correlation with uric acid level.Blood uric acid level was related with gender, smoking, BMI, triglycerides, blood glucose, C-reactive protein, high-density lipoprotein.Conclusions Blood uric acid level, BMI, blood pressure and lipids are increased in the plaque group as compared with the IMT normal group.However, blood uric acid level can not be used as an independent risk factor for IMT lesions.

Objective To investigate the value of contrast-enhanced coded harmonic angio (CHA) in evaluating the therapeutic response to combinational treatment of transcatheter arterial embolization (TAE) and radiofrequency ablation (RFA) in hepatocellular carcinoma (HCC). Methods Nineteen patients with 28 HCCs underwent percutaneous RFA in one week after TAE. The therapeutic response was assessed by contrast-enhanced CHA and three-phase dynamic CT in one week before and after the treatment. Results After TAE and RFA, no enhancement was demonstrated in 20 HCCs (71.4%) on contrast-enhanced CHA, which were considered to be completely treated. of the 20 HCCs, no blood signal was identified in 18 on dynamic CT and the conclusion cannot be drawn in the other 2 nodules due to the retention of iodized oil. On contrast-enhanced CHA, enhanced blood signals or tumor stains were identified in the remaining eight HCCs, however, four of the eight could not be evaluated on dynamic CT because of the retention of iodized oil. Conclusions Contrast-enhanced ultrasound can effectively evaluate the treatment response of HCC in combinational therapies of TAE and RFA. It is superior to three-phase dynamic CT for no influence by retention of iodized oil.

Objective To explore the value of improved elasticity scores in differentiating malignant and benign breast lesions. Methods A prospective study was done in 394 patients with 508 breast lesions confirmed by pathology and the elastographic images of the lesions were evaluated by using old and improved elasticity scores respectively. Results The elastographic images of the lesions could be evaluated and classified in all patients by improved elasticity scores but could not be evaluated and classified in 82 lesions by old elasticity scores. The accuracy of ultrasonic elastography for diagnosing benign and malignant breast lesions was 88.8% and 78.1%, respectively by old elasticity scores and improved elasticity scores. Conclusions The elastographic images of breast lesions were accurately evaluated by using improved elasticity scores, and the use of improved elasticity scores is helpful to reduce the biopsy which is not necessary.

Objective To study the relationship between apoptosis regulation and epidermal proliferation in psoriasis. Methods The expression of apoptosis molecule PDCD5 (programmed cell death 5) on psoriatic lesions was observed by direct immunofluorescence. The positive rates and the average of fluorescence intensity of PDCD5 were analyzed quantitatively with FACS and computer CELL Quest software. The expression of PDCD5 mRNA in psoriatic lesions was detected by RT-PCR. Results The expression of PDCD5 protein was obviously lower in psoriatic epidermal cells than that of the normal skin. The positive rate and the average fluorescence intensity of PDCD5 in psoriatic epidermal cells were notably lower than those of the normal skin (P

Objective To investigate the changes of plasma soluble CD40 (sCD40) and soluble CD40L (sCD40L) in patients with chronic renal failure( CRF) and their potiential mechanisms in renal injury and immunodeficiency. Method From September to December 2006, 30 CRF patients without hemodialysis (CRF group) in department of Nephrology and 30 uremic patients receiving maintenance hemodialysis for more than 3 months ( HD group) in dialysis center in Beijing TongRen Hospital of Capital Medical University, were enrolled in this study. The normal control group consisted of 20 healthy volunteers who matched with study subjects for age and gender. The levels of plasma sCD40 and sCD40L were measured by the method of enzyme linked immunosorbent assay (ELISA). The relationship between sCD40, sCD40L and related factors were analyzed, and the influence of hemodialysis on sCD40 and sCD40L were observed. ANOVA and Pearson correlation analysis were used in statistical analysis. Results (1) The sCD40 levels in CRF group and HD group were significantly higher than those in control group(P ＜ 0.01). The sCD40 levels in HD group were also higher than those in CRF group(P ＜ 0.01). (2) The sCD40L levels in CRF group and HD group were significantly higher than those in control group (P ＜ 0.01). The sCD40L levels in HD group were slightly higher than those in CRF group, but without significant difference (P ＞ 0.05). (3) In CRF group, the sCD40 levels correlated positively with serum creatinine (Scr) and C-reactive protein(CRP) (r = 0.637,P ＜ 0.01,r = 0.551,P ＜ 0.05). The correlations between sCD40L and Scr and CRT were also seen (r = 0.553, P ＜ 0.05, r = 0.686,P ＜ 0.01), whereas the correlation with blood pressure,hemoglobin (Hb), platelet(PLT), white blood cell(WBC), serum albumin(Alb), glucose (Glu),blood urea nitrogen(Bun)and serum lipid was no seen (P ＞ 0.05). In HI) group, there were no correlations between sCD40,sCD40L and above parameters (P ＞ 0.05), there were also no correlations between sCD40, sCD40L and duration of the treatment by dialysis and dialysis adequacy(Kt/V) (P ＞ 0.05). (4)After one HD session, the post-HD levels of sCD40 were slightly higher than pre-HD levels, but without statistical difference ( P ＞ 0.05). The post-HD levels of sCD40L were obviously lower than pre-HD levels, with significant difference (P ＜ 0.01). Conclusions The levels of sCD40 and sCLMOL in CRF patients,particularly in HD patients, were significantly higher than those of controls, which may participate in pathogenesis of renal injury and immunodeficiency.

Objective:To investigate the effect of body mass index(BMI), waist circumference(WC) and waist hip ratio (WHR) on blood pressure, serum lipids, renal function, protein and lymphocyte. Methods:175 middle and elderly patients were measured. Results:Compared to normal weight cases, SBP and uric-acid were significantly higher in over-weight cases. Triglyceride, SBP and DBP were all significantly higher in obesity cases. When waist circumference was beyond 85 cm in women, triglyceride, lymphocyte and DBP were all significantly higher than those in normal weight women. When waist circumference was beyond 90 cm in men, triglyceride was significantly higher than that in normal weight men. Conclusion:When BMI increases, triglyceride and blood pressure will increase accordingly. When WC is higher than normal, triglyceride in male and female will be higher. Control of obesity, is helpful to prevent cardiovascular diseases.

Objective To investigate the diagnostic value of strain ratio for differentiation breast benign and malignant solid lesions. Methods Two hundred and sixty-nine patients with 377 lesions (278 benign, 99 malignant) were included in the study. Ultrasonography found the lesions, then ultrasonic elastography got the strain images. By the strain ratio measure method equipped with the ultrasonic machine, strain ratio of the lesion was calculated. Compared with the pathologic diagnosis, the cut-off point of strain ratio was determined with receiver operating characteristic curve. Results There was significant difference between the strain ratio of benign and malignant lesions( P <0. 05). The cut off point of strain ratio was determined as 3. 08, Youden's index was 0. 88,sensitivity was 97. 38% ,and specificity was 91. 33%. Conclusions Strain ratio could be used to differentiate benign and malignant lesions in breast and would be a new diagnostic standard in future.

Purpose The clinical advantages of ~(131)I SPECT/CT fusion imaging over planar imaging of differentiated thyroid cancer(DTC) were studied. Materials and Methods 97 DTC accepting ~(131)I therapy after thyroid surgery underwent planar ~(131)I whole-body scan(WBS) and SPECT/CT fusion imaging. The diagnostic performance of ~(131)I-WBS and SPECT/CT were comparatively analyzed. Results The patients had totally 251~(131)I-WBS and 102 SPECT/CT imaging. In comparison to WBS, SPECT/CT fusion images were proven of a few advantages, such as: (1)Fused and 3D images being obtained by SPECT/CT;(2)finding more focus;(3)correctly confirming the position of lesions;(4)locating some ~(131)I negative lesions;and (5)distinguishing physiological or polluted activity. Conclusion ~(131)I SPECT/CT fusion imaging could clearly reveal the shape、sizes、biological status and relation to surrounding tissues, thus providing additional information to ~(131)I-WBS in DTC.

Objective To investigate the value of serum interleukin-6 (IL-6) ,haptoglobin (HPT) and amy-loid A (SAA) in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) with pneumonia.Methods 87 cases of acute exacerbation of COPD without pneumonia and 76 cases with pneumo-nia ,admitted in the hospital from December 2015 to March 2017 ,were selected as COPD without pneumonia group and COPD with pneumonia group.62 healthy people who underwent the healthy assessment during the same period were selected as the control group.The changes of serum IL-6 ,HPT and SAA levels in three groups ,the value of serum IL-6 ,HPT and SAA levels in detecting COPD with pneumonia and the correlation of IL-6 ,HPT and SAA were compared.Results COPD patients with serum IL-6 ,HPT and SAA were higher than group COPD with pneumonia group and control group ,and COPD is not associated with serum IL-6 , HPT and SAA in pneumonia group than the control group (P＜0.05) ;IL-6+ HPT+SAA diagnostic specifici-ty ,sensitivity and positive predictive value is higher than IL-6 ,HPT and SAA (P＜0.05) ;IL-6 and HPT was positively related with SAA and HPT was positively correlated with SAA.The serum levels of IL-6 ,HPT and SAA in the COPD with pneumonia group were higher than those in the COPD without pneumonia group and the control group ,and the serum IL-6 ,HPT and SAA levels in the COPD without pneumonia group were higher than those in the control group ,and the difference was statistically significant (P＜0.05).The diagnos-tic specificity ,sensitivity and positive predictive value of the combined detection of IL-6 ,HPT and SAA levels were higher than those of single detection of IL-6 ,HPT and SAA level ,and the difference was statistically sig-nificant (P＜0.05) ;IL-6 level was positively correlated with HPT and SAA levels ,and HPT was positively correlated with SAA level.Conclusion The levels of serum IL-6 ,HPT and SAA in patients with acute exacer- bation of COPD increased.The combined detection of the three had relatively high sensitivity and specificity , and the levels of IL-6 ,HPT and SAA were positively correlated.