Objective:To investigate the inhibition control characteristics in college students with mobile phone addiction,then to design tactics to enhance their inhibition control ability.Methods:Totally 150 college students were surveyed with the Mobile Phone Addiction Index (MPAI)to filter out the high and low mobile phone addiction.Thirty students with more than eight affirmative answers to the seventeen MPAI items were selected as the mobile phone addiction group while another 30 students with less than eight affirmative answers were selected as non addicts group of MPAI.All participants were asked to complete task of stop signal.Results:In college students with mobile phone addiction,the stop-signal reaction times were longer than that in the students without mobile phone addiction [(292.0 ±89.4)ms vs.(241.1 ±95.7)ms,P <0.05],while the non-signal reaction times were shorter than that in those without mobile phone addiction [(494.2 ±103.8)ms vs.(597.6 ±108.9 )ms,P<0.01].Conclusion:It suggests that the college students with mobile phone addiction may have poorer inhibitory control.

BACKGROUND:Shape memory polymer is a new type of functional material. The applications of shape memory polymers in the biomedical field have increasingly been paid close attention. OBJECTIVE: To summarize the characteristics and applications of shape memory polymers. METHODS: SpringerLink and China Journal Ful text Database were searched for articles related to shape memory polymers. RESULTS AND CONCLUSION: As a new type of inteligence material, shape memory polymers have lots of advantages compared with shape memory aloy and shape memory ceramics, such as low density, light weight, low cost, high shape-recovery rate, easy to regulate the shape memory temperature, to dye, to shape and to be stimulated under expected switch temperature. Especialy for polyurethane, the structure-property relationships are extremely easy to control, the shape memory temperature can be set in a wide range from-30℃ to 70℃, and it has the biocompatibility. Due to these, shape memory polymers have great potentials in applications of biomedical engineering. But the comprehensive properties of the developed shape memory polymers are not satisfactory. For example, the polynorbornene has big recovery stress, fast recovery velocity and high recovery precision, but its relative molecular mass is very big, the molecularchain is long, and processing is difficult. Furthermore, most of shape memory polymers have smal recovery stress, slow recovery velocity, low recovery precision and unsatisfied repeat memory effect. The key problems for shape memory polymers include optimization of the function of shape memory and improvement of the comprehensive properties based on the technologies of molecular design and material modification.

Objective To evaluate the predictive values of ABCD,ABCD2 ,SPI-Ⅱ and ESSEN score models for the patients with high-risk transient ischemic attack (TIA)to develop to cerebral infarction in short and long term. Methods The ABCD, ABCD2 , SPI-Ⅱ and ESSEN scores of 235 cases of TIA patients were retrospectively analyzed.The incidence of cerebral infarction was followed up for 7 d and 1 year, and the receiver operating characteristic curve (ROC)was drawn to calculate the area under curve (AUC)to assess the accuracy of the score models,and compared with the original model and the relative risk (RR)value was calculated.Results The 7 d-incidence and 1 year-incidence of cerebral infarction in the 235 TIA patients were 9.36 % and 20.43%.The AUC of ABCD,ABCD2 ,SPI-Ⅱ and ESSEN models for 7 d were 0.70,0.74,0.67,and 0.62.The AUC of 1 year were 0.62,0.62,0.64,and 0.65.Compared with the orginal models,the RRs for 7 d of ABCD score model of the TIA patients in low,middle,and high risk groups were 0.09,0.92,and 0.72;the RRs of ABCD2 score model were 0.49,0.59,and 0.65;the RRs of SPI-Ⅱ score model were 0.58,0.87,and 0.55;the RRs of ESSEN score model were 0.11,0.18,and 0.55.Conclusion ABCD,ABCD2 ,SPI-Ⅱ and ESSEN score models can be used to assess the risk of cerebral infarction after TIA in Chinese population.The ABCD2 score model is of great value for short-term risk prediction,and the ESSEN score model is more value for long-term risk prediction.

Objective To explore the application value of 64-slice spiral CT cardiac enhancement scanning in the morphological as-sessment of left atrial appendage(LAA).Methods Patients were selected retrospectively between April 16,2013 and May 1,2013, including 142 patients with sinus rhythms underwent MDCT coronary angiography,25 patients with atrial fibrillation underwent MDCT pulmonary vein-left atrial angiography.All images were post-processed,datas were measured and the morphology of left at-rial appendage were classified into different types.Results 167 patients were enrolled,including 88 males and 79 femals,age 53.7± 8.9 years.Anatomical relationship of the orifice of left atrial appendage to left superior pulmonary vein(LSPV)were classified as high type (superior to LSPV,2.4%),middle type(parallel to LSPV,86.2%),low type(inferior to LSPV,11.4%).LAA orifice could be classified into three types including oval(162,97%),round-like(3,1.8%)and drop-like(2,1.2%).LAA morphology could be classified in four types including Cauliflower(35,21%),Windsock(41,24.6%),Cactus(7,4.2%),Chicken-wing(84, 50.3%).Patients with atrial fibrillation have a larger LAA volume than who with sinus rhythm.Conclusion 64-slice spiral CT car-diac enhancement scanning can provide a vivid and intuitive reference to the anatomy of LAA and its adjacent structures,and it can also provide quantitative evaluation of LAA anatomical parameters,so it may have a nice significance in the direction of LAA occlu-sion.

Objective To analyze pharmacologic action features of single Chinese herbal medicine for the treatment of fatty liver based on literature; To provide references for clinical treatment of fatty liver.Methods Animal research literature about single Chinese herbal medicine for the treatment of fatty liver in CNKI, Wanfang database, and VIP from January 2003 to December 2014 was retrieved by computers. The number of single Chinese herbal medicine and the pharmacologic action features of active ingredients (or extracts) were statistically concluded. Results A total of 279 articles were retrieved, including 67 kinds of single Chinese herbal medicine, among which 8 were used to treat AFLD, 45 were used to treat NAFLD, and 14 were used to treat AFLD and NAFLD simultaneously. Pharmacologic action features of the medicine for AFLD mainly included reducing lipid, protecting liver, antioxidation, and anti-inflammation. Pharmacologic action features of the medicine for NAFLD had the effects of improving insulin resistance additionally.Conclusion Chinese herbal medicine for the treatment of AFLD and NAFLD shows significant efficacy, having the features of multiple pathways and liver damage resistance, which provide references for clinical treatment of fatty liver.

Objective To explore the prognosis and management of atrial fibrillation (AF) in patients with atrial septal defect(ASD) accompanied by AF after transcatheter closure of ASD. Methods During the period from July 2010 to May 2013, a total of 24 patients with ASD accompanied by AF were admitted to authors’ hospital to receive transcatheter closure of ASD. Electrocardiogram (ECG), chest X-ray film and transthoracic echocardiography (TTE) were performed before and one day after the operation. Follow-up information was obtained through telephone or at out-patient clinic interview. Results Successful occlusion of ASD was obtained in all patients, and in no patient the AF rhythm turned to sinus rhythm after the procedure. In one patient preoperative AF turned to postoperative atrial flutter, and AF recurred in one case who had received transcatheter ablation of AF before the procedure. One female patient developed gastric bleeding during the course of orally taking warfarin, and she died of cerebral infarction at three days after ceasing the use of warfarin. Of the 24 patients, no anticoagulant drug was used in 5 (20.8%), oral administration of aspirin was given in 7 (29.2%), and oral medication of warfarin was employed only in 11 (45.8%). Conclusion The spontaneous conversion rate of AF is very low in patients with ASD complicated by AF after transcatheter closure of ASD. Postoperative medication of anticoagulation should be strictly standardized and carefully managed.

OBJECTIVETo investigate the bacterial flora and their drug resistance in hospitalized burn patients on tropical islands.

METHODSRetrospective study was carried out to analyze pathogenic microorganisms and their drug resistance characteristics in 392 burn patients hospitalized during 2000-2005.

RESULTS(1) Totally 671 strains of bacteria were isolated, among which Pseudomonas aeruginosa, Staphylococcus aureus, Aerobacter cloacae and Acinetobacter species were predominant, but the isolation rate of Pseudomonas aeruginosa was declining compared with that in 1990's. (2) The resistance rate of Pseudomonas aeruginosa to imipenem and cefepime was 32.2% and 36.7% , respectively, while that to other antibiotics was above 80%. (3) Among 141 strains of Staphylococcus aureus, 89 strains (63.1%) of MRSA were isolated, and none of them were resistant to Vancomycin.

CONCLUSIONPseudomonas aeruginosa, Staphylococcus aureus, Aerobacter cloacae and Acinetobacter species were predominant in tropical islands. The species of the pathogens are changing . The drug resistance rates of Pseudomonas aeruginosa and Staphylococcus aureus are rather high.

Adolescent ; Adult ; Aged ; Anti-Bacterial Agents ; pharmacology ; Burns ; drug therapy ; microbiology ; Child ; Child, Preschool ; Drug Resistance, Bacterial ; Female ; Humans ; Infant ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Pseudomonas aeruginosa ; drug effects ; isolation & purification ; Retrospective Studies ; Staphylococcus aureus ; drug effects ; isolation & purification ; Tropical Climate ; Young Adult

Objective To discover the potential compounds with lipid-lowering`effect in Chinese medici-nal based on PPARγ-LXRα-ABCA1 pathway by using pharmacophore and molecular docking technology. Methods Firstly, PPARγand LXRαwere selected as search keywords, and the efficacy-identifying models of their agonists were built respectively.The optimal pharmacophore models of PPAR γand LXRα were obtained after validation and evaluation.Traditional Chinese medicine database(TCMD)was se-lected according to the optimal pharmacophore models.The primary screening compounds were retained based on the Lipinski five rules and Fitvalue.Finally,molecular docking was employed to refine the out-comes of pharmacophore model and analyze the binding mode of protein-ligand.The compounds with higher docking scores and amino acids were retained.Results In this study, the optimal model of PPARγagonists was built,which contains one hydrogen bond acceptor,one hydrophobic group and two aromatic rings;The optimal model of LXRαagonists contains two hydrogen bond acceptors, one hydro-phobic group and two aromatic rings.Meanwhile,the crystal structure of PPARγand LXRαbuilt by mo-lecular docking method was used in molecular docking study.According to the pharmacophore and out-comes of Lipinski five rules, there were 22 and 180 compounds obtained respectively.Based on the screening standard of docking studies, the artabotrycinol and hinoki flavone were identified as potential agonists of PPARγ,while anomalamide(artemisia annua)and trichosanatine(trichosanthes rosthornii) were identified as potential agonists of LXR α.These potential compounds could play a key role by acting on the corresponding target in PPAR γ-LXRα-ABCA1 pathway respectively.Conclusion This study pro-vides an efficient method for screening potential agonists of PPAR γand LXRαin TCMD and potential compounds that increase the expression of ABCA 1,which could serve as the candidate compounds in the development of new drugs for hyperlipidemia.

Objective To construct a radiomics nomogram combining clinical and a radiomics signature for distinguishing type Ⅱpapillary renal cell carcinoma(pRCC)from atypical clear cell renal cell carcinoma(ccRCC).Methods Clinical and CT data of patients with pathologically confirmed type Ⅱ pRCC(62 cases)and atypical ccRCC(56 cases)were analyzed.A random sample was divided into a training set(82 cases)and a test set(36 cases)in a ratio of 7∶3.Clinical factors were screened to construct clinical factor models.A total of 1 595 radiomics features of tumors were extracted from the corticomedullary phase CT images and based on the most effective features to construct a radiomics signature and calculate the radiomics score(Rad-score).A radiomics nomogram was constructed by combining the Rad-score and independent clinical factors.Receiver operating characteristic(ROC)curve was used to assess the clini-cal usefulness of the models.Decision curve analysis(DCA)was used to assess the difference between the models.Results The radiomics signature showed good discrimination in training set area under the curve(AUC)0.894[95％confidence interval(CI)0.834-0.947]and test set AUC 0.879(95％CI 0.774-0.963).The AUC of the clinical factors model in training set and test set were 0.725(95％CI 0.646-0.804)and 0.698(95％CI 0.567-0.819).The AUC of the radiomics nomogram in training set and test set were 0.901(95％CI 0.840-0.953)and 0.901(95％CI 0.809-0.975).DCA demonstrated the radiomics nomogram outmatched the clinical factors model and radiomics signature in the aspects of clinical usefulness.Conclusion Radiomics nomogram based on enhanced CT can provide good prediction of type Ⅱ pRCC and atypical ccRCC preoperatively,improve the diagnostic accuracy and provide guidance for future clinical treatment.

Objective Comparison of therapeutic effects between retrograde island flap of the intrinsic artery and dorsal perforator island flap for repairing skin defects at the distal phalanx of the finger.Methods A total of 128 patients with skin defects at the distal phalanx of the finger were enrolled from August 2020 to September 2022 at Huai'an Second People's Hospital.These patients had 128 affected fingers.Using a random number table,they were divided into two groups:collateral group(64 case)and dorsal branch group(64 case).The collateral group underwent retrograde island flap surgery using the intrinsic artery,while the dorsal branch group underwent repair surgery using the dorsal perforator island flap of the intrinsic artery.Surgical time and intraoperative blood loss were recorded.Follow-up was conducted for 12 months postoperatively,evaluating graft survival rate,finger joint function,sensory function of the transplanted flap at the distal phalanx,degree of wound scar,and postoperative complications.Results The surgical time for the collateral branch group and the dorsalis branch group was(50.03±12.41)minutes and(54.78±15.65)minutes,respectively.The intraoperative blood loss was(22.65±10.03)ml in the collateral branch group and(26.52±12.61)ml in the dorsalis branch group.There was no statistically significant difference in surgical time or intraoperative blood loss between the two groups(P＞0.05).At the 12-month follow-up,all patients in both groups had normal healing of the distal defect,and the success rate of flap transplantation was 100.00％in both groups.There was no statistically significant difference between the groups in terms of flap transplantation success rate(P＞0.05).At the 12-month postoperative period,the Vancouver Scar Scale(VSS)score was(3.15±0.69)in the collateral branch group and(3.17±0.62)in the dorsalis branch group,with no statistically significant difference between the two groups(P＞0.05).The Tangibility,Appearance,and Mobility(TAM)score was(9.71±0.65)in the collateral branch group and(10.93±0.71)in the dorsalis branch group.The TAM score was significantly lower in the collateral branch group compared to the dorsalis branch group(P＜0.05).The two-point discrimination of the flaps was(8.93±2.05)mm in the collateral branch group and(7.51±1.64)mm in the dorsalis branch group.The two-point discrimination was significantly higher in the collateral branch group compared to the dorsalis branch group(P＜0.05).There were 2 cases of venous reflux disorder and 1 case of cold intolerance in the collateral branch group,while no complications occurred in the dorsalis branch group.There was no statistically significant difference in complications between the two groups(P＞0.05).Conclusion Compared to the reverse island flap repair using the intrinsic arterial system,the dorsal island flap repair using the intrinsic arterial system for treating distal skin defects of the finger provides better postoperative functional recovery of the finger and relatively lower risk of venous congestion.