OBJECTIVE:To study the preparation and in vitro dissolution of ethyl pepper solid dispersion. METHODS:Sol-vent-melting method was adopted. Using polyethylene glycol 6000(PEG-6000)as carrier,the effects of different drug-loading ratios (1∶1,1∶5,1∶7,1∶10,1∶15,1∶18,1∶20)on the dissolution of ethyl pepper solid dispersion was invesigated. The stability of crude drug ethyl pepper at 85℃was determined. Furthermore,differential scanning calorimetry and X-ray powder diffraction meth-od were used to identify the existence of ethyl pepper in the solid dispersion. RESULTS:The dissolution of ethyl pepper could be improved by mixing ethyl pepper and PEG-6000 in a ratio of 1∶15,and the preparation was maintained stable at 85 ℃. The drugs part of ethyl pepper-PEG-6000 solid dispersions existed in the form of amorphous or molecular. CONCLUSIONS:The dissolution of ethyl pepper solid dispersion can be improved significantly by mixing ethyl pepper and PEG-6000 (1∶15),and the dispersion keeps stable at 85℃. The study can provide reference for further study of the preparation technology of ethyl pepper preparation.

Objective:To investigate an effective paradigm to test false belief understanding for the Autism. Method:By comparing the multimedia animation presentation and the traditional presentation, 20 autistic children's false belief understanding was analyzed as well as the normal children's.Results:Animation presentation was really helpful to both groups, especially for the children with autism. The performance might be underestimated due to the application of the traditional presentation in false belief tasks.Conclusion:The autistic children's theory of mind can be measured much closer to the truth if the more apt tasks are considered.

Objective To investigate the ability of theory of mind use in elders,and determine the role of inhibitory control in the use of theory of mind. Methods The participants included 30 young-old people ,30 oldold people and 30 young people. Their ability of theory of mind use and inhibitory control were examined with The Referential Communication Task and Hayling Sentence Completion Test,respectively. Results The correct rate of referential communication task was significantly lower in old-old people (0.43 ± 0.32) than those of young-old people (0.69 ±0.24, P=0. 001 ) and young people (0. 77 ±0. 25, P＜0. 001 ). Partial correlation analysis showed that the total errors in Hayling Test-B was negatively correlated with the correct rate of Referential Communication Task ( r= -0.442, P＜0.001 ). Hiberarchy regression analysis showed that the total errors in Hayling Test-B entered the equation ( β = -0.451, P＜0. 001 ) and could independently explained 16.8% of the variance (△R2 = 0. 168, △F = 19.359, P ＜ 0.001 ) after controlling for age. Conclusion Old-old people show worse performance in the use of theory of mind. The impairment of inhibitory control can partly explain the decline of theory of mind use in old-old people.

Objective To investigate airway inflammation,number of eosinophils in blood and BALF,the expression of inhibitor protein ?(I ?B ?) and nuclear factor-?B(NF-?B) activity in lung of rat with spleen deficiency asthma,and the effect of herbs of reinforcing spleen to replenishing Qi.Method Thirty rats were randomly divided into three groups:control group(group A),spleen deficiency asthma group(group B),decoction group(group C).The pathological changes of lung was detected by HE staining,and the expression of I ?B ? and activity of nuclear factor ?B p65(NF-?B p65) was assessed in lung by immunohistochemistry.Results Compared with group A,the expression of I ?B ? significantly reduced(P

Objective To study the effect of Dragon’s blood on the expression of GSK-3? and the volume of hepatic glycogen and muscle glycogen in the liver and muscle of mice with DM. Method Selecting 120 mice of Kunming strain,and randomly dividing them into six groups:normal group,DM group,Dragon’s blood groups with three dosage 125,250,500 mg/(kg?d) and C4H11N5?HCl group. Dragon’s blood groups were given Dragon’s blood by introgastric (ig) everyday for 7 d. C4H11N5?HCl group were given C4H11N5?HCl 1 mg/(kg?d) by introgastric (ig) everyday for 7 d. The indices were observed and recorded. Result After given Dragon’s blood,the expression of GSK-3? was decreased (P

Objective To evaluate the efficacy and safety of distal embolic protection device(DPD) on acute myocardial infarction(AMI) with ST-segment elevation.Methods Two hundred and sixty-seven patients with ST-segment elevation AMI treated in emergency with percutaneous coronary intervention(PCI) from Jan.1,2004 to Dec.31,2005 in the Department of Cardiology,Xijing Hospital were studied retrospectively.169 patients were included in control group and 98 in DPD group.Patients in control group were treated with emergency PCI,while those in DPD group were treated with DPD during emergency PCI.The incidence of "no-reflow" phenomenon,thrombolysis in myocardial infarction(TIMI) 3 flow,and ST segment resolution were observed,and mortality in-hospital and left ventricular ejection fraction(LVEF) at 1 week after PCI were compared between the two groups.Results The incidence of "no-reflow" was 3.06%(3/98) in DPD group and 13.61%(23/169) in control group(P

Objective:To explore the mechanism of immunomodulatory effects of methionine-enkephalin(MENK)on dendritic cells(DC).Methods:We used scanning electronic microscope for DC morpholopy,assay for acid phosphatas activity,flow cytometry(FCM) and ELISA to study the effects of DC by MENK.Results:MENK(10-12mol/L) could increase the expression of MHC classⅡ,CD86 and CD40 molecules on DC surface(P

AIM: To observe the changes of inflammatory factors and blood coagulatory factors and effects of antithrombin Ⅲ (ATⅢ) on activated inflammatory factors and blood coagulatory factors in rats with hemorrhagic shock. METHODS: The rat model of hemorrhagic shock was set up. 40 SD rats were randomized into four groups: sham operation, shock, routine dose ATⅢ and high dose ATⅢ groups, each group was composed of 10 SD rats. Shock group was administered common resuscitation fluid, routine dose ATⅢ group was administered ATⅢ 20 U/kg, high dose ATⅢ group was administered ATⅢ 100 U/kg everyday for successive three days. Plasma NF-?B, 6-Keto-prostaglandinF1?, E-selectin, sICAM-1, thrombin-ATⅢ complexes, thrombinogen fragment F1+2 (PF F1+2), D-dimer and TMD levels were detected. RESULTS: Plasma NF-?B, sICAM-1, E -selectin levels were significantly lower in high dose ATⅢ group than those in shock group and routine dose ATⅢ group (P

Nealy 80% cerebral palsy infant are accompanied with speech obstacle at different degree, which always lead to intelligent and communication difficulties, much attention should be paid on special training. This arcle will introduce the four main aspects types of speech obstacle, the reason of speech obstable, the examination and evaluation of speech obstacle, and treatment of speech obstacle.