Objective:To analyze the effect of tanreqing injection on the serum levels of transforming growth factor-β (TGF-β) and matrix metalloproteinases-9 (MMP-9) of patients with chronic obstructive pulmonary disease (COPD).Methods:102 patients with COPD were divided into the control group and the observation group according to random number table method,52 cases in each group.The control group was treated with routine therapy,and the observation group was treated with Tanreqing injection based on the control group.The serum TGF-β,MMP-9 levels,forced vital capacity (FVC),1 s forced expiratory volume (FEV1),partial pressure of carbon dioxide (PaCO2),oxygen partial pressure (PaO2),CD4+,CD86,CD4+/CD8+,syndrome integral,clinical efficacy and incidence of side effects were observed and compared between the two groups.Results:After treatment,the serum TGF-β,MMP-9 levels,PaCO2 and syndrome integral of observation group were significantly lower than those of the control group,the PaO2,CD4+,FVC,FEV1,CD4+/CD8+ and the clinical efficacy of observation group were obviously higher than those of the control group (P＜0.05).There was no significant difference in the incidence of side effects between the two groups (P＞0.05).Conclusion:Tanreqing injection could effectively reduce the serum levels of TGF-β and MMP-9,and improve the arterial blood gas,lung function and immune function in treatment of patients with COPD.

Objective To investigate the effect of heat-sensitive point on improvement of lung function and life quality of COPD patients in stable period.Methods A total of 80 COPD patients in stable period in our hospital were randomly divided into observation group and control group,with 40 cases in each group.The control group received conventional therapy and treatment,and the observation group was given heat-sensitive point based on the control group,the changes of pulmonary function and quality of life before and after treatment were compared.Results There was no significant significance in pulmonary function and life quality in the two groups before treatment (P ＞0.05).After treatment,the lung function and life quality in the two groups were improved,but FVE1,FVE1/FVC,FVE1％ in the observation group were higher than that in the control group,influence score and symptom score and activity strength scores were lower than that in the control group,the differences were statistically significant (P ＜ 0.05).Conclusion Heat-sensitive points can significantly improve the pulmonary function of COPD patients in stable period,improve the life quality,and reduce adverse reactions,so it is worth promoting.

Objective To investigate the effect of heat-sensitive point on improvement of lung function and life quality of COPD patients in stable period.Methods A total of 80 COPD patients in stable period in our hospital were randomly divided into observation group and control group,with 40 cases in each group.The control group received conventional therapy and treatment,and the observation group was given heat-sensitive point based on the control group,the changes of pulmonary function and quality of life before and after treatment were compared.Results There was no significant significance in pulmonary function and life quality in the two groups before treatment (P ＞0.05).After treatment,the lung function and life quality in the two groups were improved,but FVE1,FVE1/FVC,FVE1％ in the observation group were higher than that in the control group,influence score and symptom score and activity strength scores were lower than that in the control group,the differences were statistically significant (P ＜ 0.05).Conclusion Heat-sensitive points can significantly improve the pulmonary function of COPD patients in stable period,improve the life quality,and reduce adverse reactions,so it is worth promoting.

Humans ; Pregnancy ; Female ; Umbilical Cord/diagnostic imaging* ; Pregnancy Outcome ; Ultrasonography ; Ultrasonography, Prenatal

OBJECTIVE: To investigate the clinical and pathological manifestation, prognosis of unilateral allergic fungal sinusitis (AFS), and to analyze the characters and treatment paradigm of unilateral AFS. METHOD: Clinical and pathological information of 10 cases of unilateral AFS were analyzed. Nasal endoscopy, skin prick test, and visual analogue score (VAS) of severity of illness were taken before surgery. Mucosa membrane and inspissated secretion obtained during endoscopic surgery were stained with hematoxylin-eosin and silver hexosamine. Regular clean of sinus and intranasal steroid spray were taken after surgery. RESULT: Endoscopy showed that 5 cases had pale mucous membranes in the ipsilateral nasal cavity. Skin prick test was positive in all patients. Nasal CT scan demonstrated unilateral lesion in all 10 patients. In the involved sinus, all 10 patients had brown or yellow brown viscous secretion, which demonstrated eosinophilic amorphous mass with accumulation of eosinophils, Charcot-Leyden crystallization and fungal hyphae under microscope. The number of eosinophils in lamina propria of sinus mucosa membrane was 72 +/- 11/hpf. After follow-up for 16 to 26 months(mean 22 months), 9 cases were cured and 1 improved. The pre-operative VAS was 8.5 +/- 1.2, and the post-operative VAS was 1.1 +/- 1.0 (P < 0.01). CONCLUSION The systemic and local allergic reaction may co-exist in unilateral AFS, in which local hypersensitivity may be the dominant reaction. Endoscopic sinus surgery and intranasal steroid spray are effective in the treatment of unilateral AFS.
Adult ; Female ; Humans ; Male ; Middle Aged ; Mycoses ; diagnosis ; therapy ; Rhinitis, Allergic ; Rhinitis, Allergic, Perennial ; diagnosis ; microbiology ; therapy ; Sinusitis ; diagnosis ; microbiology ; therapy