Arsenic is one of the important metalloid elements, which is widely distributed in nature. Arsenic can cause many health hazards. However, the toxic mechanisms of arsenic have not yet been fully understood. In recent years, many studies have shown that epigenetic regulation and control mechanism is associated with arsenic toxicity. Histone modification is an important epigenetic regulation and control mechanism, changes in its patterns may be one of the mechanisms by which arsenic alters the gene expression. We reviewed the effects of arsenic on regulation of histone methylation, acetylation, phosphorylation and ubiquitination.

Objective To investigate the diagnostic accuracy of serum interleukin-8 (IL-8) in predicting severe acute pancreatitis (SAP) by conducting a Meta-analysis.Methods Publications addressing the diagnostic accuracy of serum IL-8 in the diagnosis of SAP were selected from Pubmed,Embase,Cochrane library,CBM,Wanfang,VIP,and CNKI databases.Data analysis was conducted by STATA 9.2software.Results According to the inclusion criteria,five diagnosis tests were retrieved,including 299 SAP patients and 2956 healthy controls.Meta-analysis results showed that the pooled sensitivities of IL-8 were 65.8％and 70.9％ for days 1 and 2,respectively; the pooled specificities were 66.5％ and 91.3％ for days 1 and 2,respectively; the pooled positive predictive value were 54.7 and 86.2 for days 1 and 2,respectively; the pooled negative predictive value were 75.9 and 80.3 for days 1 and 2,respectively; the area under curve (AUC) were 0.73 (95％ CI:0.21-0.97) and 0.91 (95％ CI:0.85-0.92) for days 1 and 2,respectively; and the diagnostic odds ratio (DOR) were 6.1 (95％ CI:2.8-13.2) and 23.4(95 ％ CI:8.1-63.7) for days 1 and 2,respectively.Conclusions Serum IL-8 on day 1 and 2 seems to perform high accuracy in predicting SAP,but diagnosis accuracy of serum IL-8 on day 1 was superior than that on day 1.Serum IL-8 might be an important tool for early prediction and diagnosis of SAP.

Objective To observe the effect of herbal plaster at acupoints for the excess syndrome of primary dysmenorrhea and its influence on prostaglandins.Methods The patients with of primary dysmenorrhea excess syndrome were randomized into treatment group(33 cases) and control group(31 cases).The former was treated by herbal plaster at acupoints while the latter treated by orally taking Tianqi Tongjing Capsule(Radix Notoginseng for Capsule Dysmenorrhea).Before and after the treatment,the pain scores and the accompanied symptoms were observed;and PGF2? and PGE2 of peripheral blood and renal and hepatic functions were detected.Results After treatment,the pain scores of both groups were significantly decreased(P

Defibrillators, Implantable ; Electric Countershock

【Objective】 To observe the therapeutic effect of focus-locating scalp circum-needling for ischemic stroke (IS) at acute stage. 【Methods】 Sixty-one cases of IS were randomized to two groups: group A (n=31) was treated with acupuncture on homolateral scalp region projected by CT-located focus; group B (n = 30) was treated with acupuncture on conventional scalp regions which were in charge of motor and sensory function. The cases were treated with acupuncture once a day for 30 days. The changes of symptoms and signs and the plasma contents of norepinephrine (NE) and epinephrine (E) were observed before and after treatment. 【Results】 Twenty cases were cured, 10 markedly effective, 1 effective and 0 ineffective in group A; 11 cases were cured, 15 markedly effective, 4 effective and 0 ineffective in group B. The therapeutic effect in group A was better than that in group B (P

Objective: To evaluate the cytotoxicity of nano-hydroxyapatite. Methods: Mouse lung fibroblast L-929 and primary cultured human periodontal ligament fibroblast-like cells (PDLF) were cultured in the medium of extraction of nano-hydroxyapatite or commerce hydroxyapatite at 100%,50%,10% and 0% (control) respectively.Cell growth was tested by MTT assay and the cell relative growth rate (RGR) was calculated.The cytotoxicity was graded by generally accepted standard.Results: RGR of both cell lines cultured in nano-hydroxyapatite extraction was higher than that in control HA. In 7-day culture the cytotoxicity grade of HA was 1 in 100% of HA extraction medium and 0 in 100% of nano-hydroxyapatite extraction,or in 50% and 10% of nano-hydroxyapatite or control HA extraction medium.Primarily cultured PDLF showed lower RGR than L-929 under the same condition. Conclusion: Nano-HA do not have cytotoxic effect.

Objective To observe the clinical efficacy of electroacupuncture plus needle-cupping in treating lumbar intervertebral disc herniation (LIDH). Method Eighty patients with LIDH were divided into an observation group and a control group by random number table, 40 in each group. The observation group was intervened by electroacupuncture plus needle-cupping, while the control group was by electroacupuncture plus cupping. The clinical efficacy, Modified Japanese Orthopaedic Association Scores (M-JOA) and Visual Analogue Scale (VAS) were observed and comparatively analyzed. Result The total effective rate was 95.0% in the observation group, significantly different from that of the control group (P＜0.05); the M-JOA scores increased significantly (P＜0.05) and VAS scores dropped significantly (P＜0.05) in both groups, and the changes of the scores were markedly different between the two groups (P＜0.05), indicating that the improvement in the observation group was more significant. Conclusion Electroacupuncture plus needle-cupping can produce a significant therapeutic efficacy in treating LIDH.

Objective To observe the effect of acupuncture therapy of regulating Yin and Yang for the treatment of stroke,and to investigate the influence on plasma levels of calcitonin gene-related peptide(CGRP) and vascular endothelin(ET).Methods One hundred and twenty stroke patients were equally randomized into 3 groups: group A received acupuncture therapy of regulating Yin and Yang,group B received traditional body acupuncture therapy,and group C received scalp acupuncture therapy.One and a half months constituted one treatment course,and the treatment lasted 2 courses.The therapeutic effect was evaluated and the changes of plasma CGRP and ET levels were observed.Results The total effective rate was 95.0% in group A,85.0% in group B,and 82.5% in group C,the difference being significant between the three groups(P0.05).Conclusion Acupuncture therapy of regulating Yin and Yang exerts a certain effect for the treatment of stroke,and can up-regulate plasma CGRP level and decrease ET level.

Cardiovascular and cerebrovascular diseases is the most fatal diseases in the world.The prevention and treatment of cardiovascular and cerebrovascular diseases are both basic and clinical focus.Aspirin has been used as a prevention medicine in cardiovascular and cerebrovascular diseases for over a century, which is the longest one in history.Aspirin use is estimated at 100 billion tablets annually as an analgesic, antipyretic and antiplatelet drugs.However, there are still many new findings about aspirin, such as aspirin resistance and aspirin hydrolase.This paper reviews the current research advances and future directions of aspirin in cardiovascular and cerebravascwlar diseases, mainly focuses on aspirin resistance and personalized medication.

heparin coating.Conclusion Anti-thrombogenicity in vitro of biomaterials designed for the closure of congenital heart defects can be improved by immobilizing Chi/Hep conjugating onto the surface,but proliferation of HUVEC could be inhibited by Chi/Hep coating.