Objective To discuss the clinical curative effect of acupuncture and blood-enriching and brainclearing granule to treat cervical vertigo. Methods 76 cases of cervical vertigo were randomly divided into two groups. In treatment group,blood-enriching and brain-clearing granule was taken after the acupuncture treatment. And in control group,only blood-enriching and brain-clearing granule was given. Results The treatment group obviously surpasses the comparison group after the skull multi-spectra lux supersonic inspection basis artery blood stream improvement(P

Objective To explore effect of needle pot ombined with acupiont injection on the treatment of stock flank nervi cutanei inflammation. Methods 104 xases of bright stock flank nervi cutanei inflammation wese di-vided into two groups,the treatment group by the needle pot combined with acupoint injection, The control group used the needle pot treatment only. Results After Ridit analysis, the treatment group obviously surpasses the control group ( P<0.05 ), The treatment group self-conscious symptom and the body drafts vanishes the time obviously surpasses the comparison group(P<0.01 ). Along with ouow-up half ayear, recurrent rate is obviously lower than the control group( P<0.01 ). Conclusion The needle pot unifies the acupuncture point injection treatment stock flank nervi cu-tanei inflammation may clearly enhance the curative effect ,reduces the treatment time and recurrenle.

Objective To observe treatment efficacy of acupuncture on the acquired paralysls.Methods Clear diagnosis of acquired paralysis patients 105 cases of sexual walleye were selected.Randomly divided into two groups.Therapy unit gave acupuncture therapy.Results Ridit analysis of the two sets of efficacy(P < 0.05) ,significantly better in the treatment group than the control group treatment time is short group(P <0.01).Follow-up six months.No relapse.Conclusion Acupuncture treatment efficacy exact onset of acquired paralysis.

Objective To observe the clinical efficacy of pricking and bleeding the Jing-well points with three-edge needle in treating acute Bell’s palsy.Method Sixty patients with Bell’s palsy were randomized into an observation group and a control group, 30 in each group. In addition to the regular Chinese and Western medicine treatment for Bell’s palsy, the observation group also received pricking and bleeding treatment with three-edge needle at the Jing-well points. The House-Brackman (H-B) Scale and R wave in blink reflex (BR) were observed.Result The total effective rate was 93.0% in the observation group, significantly higher than 90.0% in the control group (P＜0.05). The H-B score significantly increased in both groups after intervention (P＜0.05). The observation group was significantly higher than the control group in comparing H-B score at the end of first and second treatment course (P＜0.05). The R1 and R2 waves in BR increased markedly after intervention in both groups (P＜0.05); the observation group was significantly higher than the control group in comparing R1 wave (P＜0.05), and R2 wave only at the end of the first course (P＜0.05) but not at the end of the second course (P>0.05).Conclusion Combining pricking and bleeding the Jing-well points with three-edge needle in the treatment of Bell’s palsy can enhance the therapeutic efficacy and promote the recovery of the facial nerve function.

Objective To explore the clinical efficacy of nasal irrigation for pediatric chronic sinusitis. Methods 92 children with chronic sinusitis were selected and randomly divided into treatment group(48 cases) and control group(44 cases) .The two groups were treated with routine clinical basic drugs,and the treatment group took nasal irrigation in addition.The efficacy after 1 month was compared, and then the patients were followed up for 3 months.Results The total effective rate of the treatment group was 91.7% after 1 month,which of the control group was 72.7%.After 3 months,the total effective rate in treatment group was 95.9%,which of the control group was 86.4%.There were statistically significant differences between the two groups in treatment outcomes( P=0.024, 0.011) .Conclusion The therapeutic effect of nasal irrigation for pediatric chronic sinusitis is obvious, safe and reliable.

Objective To study the effect of mitochondrial membrane potential and cellular membrane permeability in the neurotoxicity of artemether. Methods Mitochondrial membrane potential and cellular membrane permeability in pheochromocytoma cell and primary cultured rat neuronal cell were measured by flow cytometry, using rhodamine 123(Rh123) and PI as fluorescent dye, respectively. Mitochondrial swelling was measured by spectrometer. Results Artemether could decrease the mitochondrial membrane potential and increase the cellular membrane permeability in both cell types in a dose-dependent manner. In addition, artemether led to mitochondrial swelling with dose-effect and time-effect relationships. Conclusion The decrease of mitochondrial membrane potential plays an important role in the neurotoxicity of artemether. The drug can change the mitochondrial membrane potential and mitochondrial swelling by affecting the permeability transition pore complex located in the mitochondrial membrane, increasing cellular membrane permeability, causing an obstruction and finally leading to neurotoxicity.

Objective To probe into the relevant factors of unexpected psychological obstacle of blood vessel of brain and treat the countermeasure.Methods To adopt Chinese dense of anxious quantity form(HAMA) brain blood vessel unexpected patient in hospitalled to have illness coming on go on psychological obstacle evaluate for the first time to 132 and use supporting psychotherapy and routine medication mainly.Results Patient accounting for 63.3% had psychological obstacles of 132,the female's incidence of disease was higher than that of the male.The smaller the age was,the apter to present the psychological obstacle the age was.Every symptom had improvement in various degree before and after carrying on the psychotherapy.Conclusion The incidence of the unexpected patient's psychological obstacle of blood vessel of brain is relatively high.To take the effective psychological measure of rehabilitation is helpful to the whole recovery of the unexpected patient of blood vessel to brain.

Objective To evaluate and compare the efficacy and toxicity of gemcitabin(GEM) plus cisplantin and GEM on the chemotherapy of elderly patients advanced non-small-cell lung cancer (NSCLC).Methods 85 elderly patients with stage 3 to 4 NSCLC were randomized into gemcitabine plus cisplatin (group GP) and GEM (group GEM).In group GP,patients received GEM on day 1 and day 8 at dose 1.0 g/m2,add cisplatin on day 2 to day 4 at dose 75 mg/m2. In group GEM, patients would received single GEM at dose 1.25 g/m2.The the therapy circle was 3 weeks and undertaken least 2 circles before the treatment efficacy and survival would be evaluated according RECIST. Results In GP group the response rate was 48.84 ％(21/43),In GEM group the response rate was 35.71％(15/42),the difference of response rate between two groups was not statistically significant(x2=1.708,P=0.424).The median survival were 11 months to Gp group and 9 months to GEM group. The 1 year survival rates of GP group were 39.53 ％ and of GEM group were 26.19 ％. The survival time between two groups was not statistically significant(t=1.377,P=0.172).The same toxicity in both groups was defected, Nausea and vomiting occurred were more serious in GP group than that in GEM group (x2=9.796, P=0.002). Conclusion GP and GEM are both effective for treatment of elderly advanced NSCLC.There are no significantly differences on efficacy and toxicity in 2 groups. Side effects on alimentary system are obviously less in GEM group than that in GP group.

Objective To investigate the curative effect of Aidi injection solution combined withcarboplatin on controlling malignant pleural effusion(MPE).Method A total of 86 cancer patients with appearedPME were selected as our subjected who hospitalized in the First People's Hospital of Shangqiu from Feb.2012to Mar.2013.They were randomly divided into the observation group(43 cases) and the control group(43cases).Patients in the oontrol group were treated with carboplatin at dose of 100 mg/per times which was putinto the thoracic cavity,and patients in the observation group was treated with Aidi injection solution at dose of100 mg/per times beside carbeplatin.The treatment period was 4 weeks.The effect information,quality of lifeand adverse reactions were recorded.Results The total effective rate and survival quality improvement rate inobservation group were 86.05％ (37/43) and 51.16％ (22/43),higher than those in control group (67.44％(19/43),30.23％ (13/43)),and the differences were significant(x2 =4.170,3.903 ; P ＜ 0.05).There wasno significant difference in terms of the related adverse reactions between two groups(P ＞0.05).ConclusionThe therapy of Aidi injection solution plus carboplatin on controlling MPE is proved to be effective and it canimprove patients' quality of life with better safety.Therefore it is worthy of recommendation.

A melanoma is a highly malignant tumor that originates from melanocytes in the skin, mucosa, or tunica pigmentosa. The incidence and mortality rate of cutaneous melanoma are increasing annually. However, the efficacy of traditional therapy is extremely limited because of its low sensitivity and high toxicity. The application of the anti-CTLA-4 antibody and the BRAF inhibitor dramatically improves the overall survival of patients with advanced melanoma. However, their limited benefit ratio and high drug resistance curtail the use of anti-CTLA-4. Since the US Food and Drug Administration approved the use of the anti-PD-1 and anti-PD-L1 antibodies for ad-vanced melanoma in 2014, a significant survival benefit has been observed in patients with advanced melanoma. This review aims to highlight the applications of the anti-PD-1 antibody (pembrolizumab, nivolumab, and pidilizumab) and the anti-PD-L1 antibody (MP-DL3280A, BMS-936559, and MEDI4736) in the clinical treatment of melanoma by succinctly summarizing the results of recent reports.