Establishment and perfection of the medical security system is an important task in Chinas reform of the social security sytem and goes with the stream. To conform to the reform, our hospital has made the following endeavors: ①adjustment of medical quality control, laying stress on the expense quality awareness; ②improvement of medical efficiency, with the reduction of the average length of stay being the pitching in point; ③guarantee of medical quality through the implementation of the quality standards for single entity diseases; ④establishment of quality control management networks through continuous quality improvement. The above endeavors have played a positive role in promoting our hospitals conformity to the reform of the medical security system.

Primitive mammalian heart transforms from a single tube to a four-chambered muscular organ during a short developmental window. We found that knocking out global microRNA by deleting Dgcr8 microprocessor in Mesp1 cardiovascular progenitor cells lead to the formation of extremely dilated and enlarged heart due to defective cardiomyocyte (CM) differentiation. Transcriptome analysis revealed unusual upregulation of vascular gene expression in Dgcr8 cKO hearts. Single cell RNA sequencing study further confirmed the increase of angiogenesis genes in single Dgcr8 cKO CM. We also performed global microRNA profiling of E9.5 heart for the first time, and identified that miR-541 was transiently highly expressed in E9.5 hearts. Interestingly, introducing miR-541 back into microRNA-free CMs partially rescued their defects, downregulated angiogenesis genes and significantly upregulated cardiac genes. Moreover, miR-541 can target Ctgf and inhibit endothelial function. Our results suggest that microRNAs are required to suppress abnormal angiogenesis gene program to maintain CM differentiation.