Objective To discuss clinical results of the percutaneous minimally invasive LC DCP plating in treatment of tibiofibular fractures which was based on biological osteosynthesis and indirect reduction. Methods 28 patients with tibiofibular fractures were treated with indirect reduction and LC DCP plating through the tunnel inside tibia. Results All the patients were followed up for 10 to 18 months (averaging 15 m). X ray films showed that the callus appeared 4 to 7 weeks postoperatively (averaging 4.6 w). The fracture healing time were 12 to 18 weeks (averaging 12.8w). All the patients healed without fracture nonunion, delayed union or plate loosening. Plates were removed without refracture in 15 patients. Conclusions The percutaneous minimally invasive LC DCP plating for tibiofibular fractures can meet the major requirements of biological osteosynthesis and result in good results.