Objective To Discuss early clinical manifestation and early antibiotic selection of neonatal puru-lent meningitis.Methods 83 cases diagnosed as neonatal purulent meningitis in the newborn were choosed as the research object.Retrospective analysis was used.Clinical data according to the complaints of the neonatal hospitalized were collected and analyzed to understand neonatal purulent meningitis early features,and to choose the effective anti-biotics under the undefined etiology circumstances in early stage.Results The early features was fever (51.8%), following with hyper -bilirubinemia of newborn(26.5%),livor(9.6%)and rhinostegnosis(9.6%).Microbiological examination:all cases with Blood cultures and CSF cultures,the result showed pathogenic bacteria testing positive were 15 cases(18.1%),blood culture positive were 11 cases(13.3%).Epidermis staphylococcus aureus was in the lead, followed by E.coli.And CSF cultures positive had only 4 cases(4.8%),E.Coli was in the majority.Etiology clear choosed sensitive antibiotic treatment among the 83 cases.Etiology unknown cases choosed penicillin and ceftriaxone sodium combined treatment for 2 weeks.Treatment effective was 72.3%,not cured or automatic discharge accounted for 27.7%.Conclusion Lumbar puncture should be used timely,in order to avoid missed diagnosis.Early use of penicillin combined ceftriaxone sodium treatment has better effect,and is worth popularizing in the grassroots.

OBJECTIVE To compare the detection rates of Ureaplasma urealyticum(Uu),by 4 kinds rits and find out the best one.METHODS Using four kinds of mycoplasma detection kits,namely are French mycoplasmaIST2,Zhuhai Livzon′s ICS,Dark horse′s IES and Shanghai Its Prachanda,under the same conditions,the mycoplasma of the Clinical specimens for 260 cases were tested.RESULTS The detection rate of mycoplasma(Uu) for 48 hours by four kinds of brands kits about mycoplasma liquid culture was as follows 45.4% for French MycoplasmaIST2,36.2% for Zhuhai Livzon′s ICS,37.7% for Dark horse′s IES and 36.8% for Shanghai Its prachanda.The results of susceptibility test: the reagent of IST2 had.the lowest resistance to josamycin,doxycycline,clarithromycin,ofloxacin and azithromycin,and had the better results than the other three kinds of reagents.Mycoplasma reagents form different companies had significant differences in resistance rates to five kinds of antibiotics.CONCLUSIONS The results suggest that when we cultivate clinical mycoplasma should be careful to select of the mycoplasma liquid culture identification kit.

The knowledge atlas for researches of invisible knowledge management was plotted after the key words and their relationship in papers on invisible knowledge published in the past 5 years were quantitatively and qualitatively analyzed by social network analysis, co-words cluster analysis, and impact factor analysis with the journal articles covered in CNKI, Wanfang, VIP Chinese Scientific and Technological Journals Databases as the data source.The hotspots and structure in researches of invisible knowledge management were then studied in order to provide reference for the innovative development and future research of invisible knowledge management.

The functions and service of WeChat platform in domestic academic libraries were summarized in order to find out the satisfied aspects ( such as its response speed, interface design and operation) and unsatisfied aspects (interaction efficiency, push quality and popularization) of users with the functions and service of WeChat plat-form. Measures should be taken for improving the unsatisfied aspects in order to meet the users' requirements, and suggestions were put forward for optimizing the functions of WeChat platform and perfecting its service, such as atta-ching importance to the WeChat public platform construction and improving its service in order to transform the aca-demic libraries into intelligent libraries.

Objective Discusses TT3,FT3,TT4,FT4 and TSH the value which examines in the thyroid gland disease patient；analysis thyroid gland disease patient TT3,FT3,TT4,FT4 and TSH change situation.Methodsanalyzes my hospital 200 example thyroid gland disease patients,and selects the normal adult 50 examples to take the control group.analytic method to each group of examination thyroid function,and carries on the comparison to the group various targets'examination value.Results primary hyperthyroidism group T3,T4,FT3,FT4 were higher than normally,the hypothyroidism group T3,T4,Fr3,FT4 to be lowerthan normally.The TSH content primary hyperthyroidism group was lower than normally,the hypothyroidism group to be higher than normally obviously.Compares its difference with the control group to have statistics significance.hyperthyroidism group its diagnosis coincidence rate FT3 was 96%,TSH was 96%,T3 was 92%,FT4 was 90%,T4 was 88%.The hypothyroidism,the diagnosis coincidence rate respectively was：TSH was 100%,FT4 was 93%,T4 was 90%,FT3 was 77%,T3 was 70%.Conclusion FT3,T3,TSH the significance are big in the hyperthyroidism diagnosis；FT4,T4,TSH the significance are big in the hypothyroidism diagnosis.

Tag, similar to a keyword and belonging to a non-controlled term, is a marking language, and can be freely marked by its users, thus playing a role in organization of information resources.Social tagging, a tag created by network users and added to the resources they concerned, has become one of the important methods for the network information resources organizing system to organize and mange resources.Suggestions were thus put forward in this paper for improving the information retrieval function of future social tagging system by comparing its 3 functions and assessing its efficiency.

Social tagging, as an important method for organizing network resources, has been widely applied in different kinds of website with the development of Web2.0 technologies.Proposed in this paper are the suggestions for promoting the better development of healthsocial networks, such as establishing social login model, developing tag library, constructing tag automatic classification system, implementing personal recommendation system, analy -zing tag semantemes , and limiting users login rights according to the application of social tagging in health social networks and related problems needing to be solved .

Objective To study the effect of long‐acting nitrate on cardiac function and expression of AngⅡreceptor (ATR)subtypes in kidneys of chronic heart failure (CHF)rats after myocardial infarction .Methods Ninety male Wistar rats aged 10 weeks were randomly divided into control group (group A ,n=9) ,sham operation group (group B ,n=8) ,HF model group (group C ,n=9) , low Elantan dose group (group D ,n=9) ,high Elantan dose group (group E ,n=9) ,olmesartan group (group F ,n=9) ,and combined high Elantan dose and olmesartan group (group G ,n=8) .A HF model was established by ligating the left anterior descending artery .The animals received gastric drugs for 6 weeks .Their cardiac function was assyed by ultrasound echocardiography and expressions of AT1 R and AT2 R were detected by RT‐PCR and Western blot ,respectively .Results The PRA and AngⅡexpression levels were significantly higher ,the AT1 R expression level was significantly higher and the AT2 R expression level was significantly lower in group C than in group B (P<0 .01 ,P<0 .05) .The PRA and AngⅡexpression levels were significantly lower ,the AT1 R expression level was significantly lower and the AT2 R expression level was significantly higher in groups E‐G than in group C (P<0 .05 ,P<0 .01) .The receptor expression levels were much higher in group G than in group F (P<0 .05) .Conclusion Long‐term use of long‐acting nitrate can effectively improve cardiac function and protect renal function .

The social tagging system on Internet is a new model for the organization and communication of information resources in the modern network environment.After the social tagging system and information communication model were outlined,the information communication model in social tagging system and its advantages and disadvantages were analyzed with Watercress Network as an example,and suggestions were put forward for its optimization.

Objective To observe the effect of red light facial synthesis combined with comprehensive facial therapy on corticosteroid dependent dermatitis (hormone dependent dermatitis) and summarize the nursing strategies. Methods About 160 patients with hormone dependent dermatitis hospitalized in our hospital from June 2015 to March 2016, were equally divided into control group and study group:the control group was treated with conventional comprehensive therapy, while the study group with 30 min red light irradiation together with the nursing measures in the control group. The total symptom scores of the two groups were evaluated before treatment and 4 weeks after treatment. Results Before treatment, the total symptom scores of the control group were no significant difference between them (P>0.05). After treatment,the treatment effect of the study group was significantly better than that of the control group and the scores of ISS SSRI were lower than those of the control group . Conclusion The red light radiation combined with comprehensive facial therapy is effective in the treatment of corticosteroid dependent dermatitis and related nursing should be done well to promote patients relovery.