Objective: To investigate the relation between coping style and personality of patients with Graves disease. Method: Eighty two patients with Graves disease were assessed by Coping Style Questionnaire (CSQ), Eysenck Personality Questionnaire (EPQ) and Type A Behavior Questionnaire (TABQ). Results: The extroversive patients adopted more positive coping style than introversive patients did. Patients with higher EPQ-N score had higher score in negative coping. Those with Type A behavior had higher score in negative coping either. There were positive correlation between score of positive coping and that of EPQ-E, between score of negative coping and score of EPQ-N or score of Type A behavior. Conclusion: The coping style of patients with Graves disease is influenced by their personality.

Notch signal pathway is one of crucial pathways related to cell fate determination, regulating cell differentiation, proliferation and apoptosis, with an effect of organ formation and morphogenesis. Abnormal activation of Notch gene occurs in many tumor cells, such as brain tumors, breast cancer and hepatoma. Recent studies have been found that the notch pathway out of control was related with growth of ovarian cancer. And Notch3 involving in the development and progression of ovarian cancer has been attracted extensive attention by experts and scholars. This review focuses on the literatures of Notch3 and related molecules regulating the development and progression of epithelial ovarian cancer.

60 years.

OBJECTIVE:To investigate the incidence and clinical manifestations of adverse drug reactions(ADR)induced by Chinese drugs preparations in hospitals of Ya'an district and discuss the rational dosage regimen of Chinese drugs preparations.METHODS:The adverse drug reactions(ADR)induced by Chinese drugs preparations in hospitals of Ya'an district occurred from Jan.to Dec.in 2008 were analyzed statistically.RESULTS:The ADR induced by Chinese drugs preparations occurred via intravenous drip represented 76.8% of the total;lesions the skin and its appendages the major system-organ involved,represented 31.3% of the total;18.3% were induced by Shuanghuanglian injections,and serious ADR accounted for 4.0%.CONCLUSION:It is important to use traditional medicine preparations rationally so as to reduce or avoid the incidence of ADR.

Objective To analyze the application effect and safety of streamlined liner of the pharynx airway (SLIPA) anesthesia in painless fiberoptic bronchoscopy (FB).Methods Two hundred and eighty-two patients who undorwent FB examination in Kaifeng Second People's Hospital from January 2015 to January 2017 were selected and divided into observation group and control group,with 141 patients in each group.The patients in observation group were given SLIPA assisted anesthesia;the patients in control group were given endoscopic mask assisted anesthesia.The oxygen saturation (SpO2),systolic blood pressure (SBP),diastolic pressure (DBP) and heart rate (HR) of patients in the two groups were monitored.The changes of SBP,DBP and HR,the incidence of adverse reactions and the satisfaction of patient to the anesthesia were compared between the two groups.Results The fluctuation of HR,SBP and DBP of patients in the observation group was (3.52 ± 2.92) times · min-1,(7.04 ±5.30) mmHg(1 mmHg =0.133 kPa),(1.52 ± 1.63) mmHg respectively and in the control group was (5.52 ± 1.89) times · min-1,(30.12 ± 8.88) mmHg,(4.06 ± 5.78) mmHg respectively;the fluctuations of HR,SBP and DBP of patients in the observation group were significantly less than those in the control group(P ＜ 0.05).In the observation group,12 patients with cough,8 patients with abdominal distension,6 patients with pharyngeal pain,2 patients with SpO2 ≤90％,4 patients with SpO2 ＜ 85％;in the control group,57 patients with cough,32 patients with abdominal distension,47 patients with pharyngeal pain,28 patients with SpO2 ≤90％,19 patients with SpO2 ＜ 85％.The incidence of adverse reactions of patients in the observation group was significantly lower than that in the control group (x2 =27.10,61.82,41.59,72.46,87.75;P ＜0.05).The anesthesia satisfaction of patients in the observation group(97.87％) was significantly higher than that in the control group(82.98％) (x2 =29.97,P ＜ 0.05).Conclusion SLIPA assisted anesthesia has good clinical effect and safety in patients with painless FB.

Objective: To study depression of patients with Grave's disease and the therapeutic effect of Paroxetine (antidepressant). Method: 82 patients with first onset Grave's disease were collected and 52 of them had depression. The depressive patients were divided into Paroxetine and control group. All cases had the same anti-hyperthyroidism treatment. Result: 63.4% (52/82) patients with first onset Grave's disease had depression before Paroxetine treatment. After 4 weeks and 8 weeks treatment, Paroxetine group had greater decrease in FT3 and FT4, and lower scores of SDS and SAS than control group (p＜0.01). Conclusion: Paroxetine does enhance the therapeutic effect of anti-hyperthyroidism, as well as improving depression of patients with first-onset Grave's disease.

Objective To probe into the burden of caregivers of patients with Alzheimer' s disease (AD) ,coping styles and the correlation. Methods A survey involving 143 caregivers of patients with AD was conducted with Caregivers' Burden Scale and a simple Coping Style Questionnaire to analyze the burden of caregivers of AD and the characteristics of their coping styles and discuss the correlation. Results The burden of the caregivers of patients with AD was at intermediate level the score was 46. 96 ±7. 28. 78. 32% of the caregivers had intermediate burden. Both the grade of the positive coping and that of the negative coping of the caregivers of patients with AD were higher than the domestic norm (P < 0.01); the positive coping styles of the caregivers of patients with AD were negatively related with their burden while nursing; their negative coping styles were positively related with their burden while nursing (P < 0.01). Conclusion The burdens while nursing are related with their coping styles. In the aspect of nursing activity, caregivers should be encouraged to adopt positive coping styles.

Adult ; Bloodletting ; Ear ; blood supply ; Female ; Humans ; Iritis ; therapy ; Male ; Middle Aged ; Treatment Outcome ; Young Adult

Objective To investigate the impact ofα?lipoic acid(ALA)treatment on sepsis?induced acute kidney injury in rats and explore the mechanisms. Methods A total of 32 male SD rats were randomized into 4 groups:normal control group(group A),ALA?treated control group (group B),sepsis group(group C)and sepsis with ALA treated group(group D). Group A and B underwent sham operation,while CLP operations were conducted in group C and D. Rats in both group B and group D were then administered with 200 mg/kg ALA by oral gavage immediately after the surgical procedure. Twenty?four hours after the surgical procedure blood samples were obtained for the evaluation of creatinine,BUN,TNF?α,IL?6 and IL?1β. Rat kidneys were rapidly removed for PAS stain. Western blot was employed to determine the expression of NF?κB. Results Pathologi?cal changes of kidney were induced by sepsis and the level of creatinine,BUN,TNF?α,IL?6 and IL?1βwere significantly increased by 178%,66%, 55%,114%and 110%(P<0.01). respectively;simultaneously the phosphorylation and nuclear expression of NF?κB p65 in kidney tissues were significantly increased by 144%and 102%(P<0.01). Sepsis?induced acute kidney injury also significantly reduced the expression of IκBαby 61%(P<0.01). These changes were significantly suppressed by early ALA treatment. Compared with C group,the level of creatinine,BUN,TNF?α,IL?6 and IL?1βwere significantly decreased by 48%,26%,25%,37%and 40%(P<0.05),respectively,and the relative expression of IκBαwas increased by 103%(P<0.05). Conclusion The present study demonstrated that ALA can suppress the activation of NF?κB,thus ameliorat?ing sepsis?related acute kidney injury.

Objective:To establish a method for the determination of 4-methyl-N-(4-(pyridin-3-yl) pyrimidin-2-yl) benzene-1,3-diamine as an impurity in the preparation of imatinib mesylate. Methods: An LC-MS/MS method was used with ESI ion source con-trolled by a positive-ion mode. The MRM mode was performed with 278. 1/106. 1 as the scanning and ion-pair. Acetonitrile solution containing ammonium formate and formic acid was used with gradient elution. Results:The linear range was 1. 572~47. 160 ng/ml(r=0. 999 7). The detection limit was 0. 002 1ng and the limit of quantitation was 0. 006 8ng. The average recovery was 100. 9% with RSD of 2. 88. The results of specificity, solution stability, repeatability and durability all met the specification. Conclusion:The meth-od is sensitive, accurate and special in the determination of 4-methyl-N-(4-(pyridin-3-yl) pyrimidin-2-yl) benzene-1,3-diamine in imatinib mesylate.